Review
Medical Laboratory Technology
Shun Zhang, Lu Li, Jie Wang, Tingting Zhang, Ting Ye, Shuai Wang, Dongming Xing, Wujun Chen
Summary: lncRNAs, as a unique group of RNA transcripts longer than 200 nucleotides, regulate the roles of ABCA1 and ABCG1 in cholesterol efflux, influencing the development of atherosclerosis.
CLINICA CHIMICA ACTA
(2021)
Review
Pharmacology & Pharmacy
Michinori Matsuo
Summary: Prevention of atherosclerosis is of great importance due to its association with cardiovascular diseases globally. Recent studies have highlighted the significance of ABCA1 and ABCG1 proteins in preventing the progression of atherosclerosis by enhancing cholesterol efflux activity and suppressing inflammation in cells. These proteins have the potential to serve as therapeutic targets for preventing atherosclerosis and other related diseases.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jean-Baptiste Nyandwi, Young Shin Ko, Hana Jin, Seung Pil Yun, Sang Won Park, Hye Jung Kim
Summary: RA effectively promotes cholesterol efflux in macrophages by enhancing ABC transporter expression, potentially serving as a candidate therapeutic for preventing atherosclerotic cardiovascular disease complications related to diabetes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Liga Skarda, Julia Kowal, Kaspar P. Locher
Summary: ABCG1 is an ATP binding cassette transporter that removes excess cholesterol from peripheral tissues, and its mechanism of cholesterol transport is still unknown. Structural comparisons reveal differences in mechanism and substrate specificity between ABCG1, ABCG2, and ABCG5/G8, providing insights into ABCG1-mediated cholesterol transport.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Runlu Sun, Pu Fang, Jieyu Jiang, Canxia Huang, Junjie Wang, Qi Guo, Hongwei Li, Xiaoying Wu, Xiangkun Xie, Yuan Jiang, Qian Chen, Jinlan Bao, Jingfeng Wang, Hong Wang, Yuling Zhang
Summary: The study found that MCP-1 impairs cholesterol efflux to large HDL2 particles in adipocytes, which is reversed by insulin through upregulating ABCA1, ABCG1, and SR-BI. Insulin may improve cholesterol imbalance in adipocytes by an anti-inflammatory effect.
CARDIOVASCULAR DRUGS AND THERAPY
(2022)
Article
Biology
Jialiang Yang, Yuhong Chen, Tongdan Zou, Bai Xue, Fang Yang, Xiangzhou Wang, Yibo Huo, Boyun Yan, Yuxia Xu, Shiyu He, Yi Yin, Jing Wang, Xiong Zhu, Lin Zhang, Yu Zhou, Zhengfu Tai, Ping Shuai, Man Yu, Qian Luo, Yilian Cheng, Bo Gong, Xianjun Zhu, Jing Zhang, Xinghuai Sun, Ying Lin, Houbin Zhang, Zhenglin Yang
Summary: This study reveals that lower ABCA1 expression and lower HDL are risk factors for primary open-angle glaucoma (POAG). Ablation of Abca1 in mice leads to elevated cholesterol levels in the retina, causing a POAG-like phenotype. Treatment with atorvastatin reduces cholesterol levels in the retina, improving metabolism and protecting retinal ganglion cells.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Article
Multidisciplinary Sciences
Jere P. Segrest, Chongren Tang, Hyun D. Song, Martin K. Jones, W. Sean Davidson, Stephen G. Aller, Jay W. Heinecke
Summary: By using simulations, the authors of this study uncover the mechanism by which ATP-binding cassette transporter A1 (ABCA1) functions in extracting lipids from the outer face of the plasma membrane and facilitating the production of high density lipoprotein (HDL). Contrary to existing models, their findings suggest that ABCA1 removes lipids from the plasma membrane and forces them through its gateway and annulus into an elongated hydrophobic tunnel. This study provides important insights into the function of ABCA1 and presents a potential target for further research.
NATURE COMMUNICATIONS
(2022)
Article
Endocrinology & Metabolism
Adrian Post, Erwin Garcia, Eke G. Gruppen, Daan Kremer, Margery A. Connelly, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: In euthyroid individuals, higher levels of FT3 are associated with higher total HDL particle concentration and lower HDL particle size. The associations with FT4 or TSH are less pronounced or not significant.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Pharmacology & Pharmacy
Masatsune Ogura
Summary: Homozygotes with loss-of-function mutations in ABCA1 develop Tangier disease, which is characterized by significantly reduced or absent blood high-density lipoprotein (HDL) cholesterol. ABCA1 was identified as a key player in HDL production based on studies involving ABCA1-deficient mice. While the activation of ABCA1 and promotion of cholesterol efflux could potentially lead to the development of anti-atherosclerotic drugs, it is challenging to consider simple ABCA1 activation or cholesterol efflux promotion as an effective strategy for intracellular cholesterol homeostasis. Currently, there is no evidence supporting the preventive effect of HDL-increasing drugs that enhance ABCA1 expression on atherosclerotic disease in humans. However, in situations where intracellular cholesterol homeostasis is disrupted by inflammation, aging, or metabolic abnormalities, restoring ABCA1 expression and cholesterol efflux may be a useful strategy.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2022)
Article
Endocrinology & Metabolism
Sara Sokooti, Jose L. Flores-Guerrero, Lyanne M. Kieneker, Hiddo J. L. Heerspink, Margery A. Connelly, Stephan J. L. Bakker, Robin P. F. Dullaart
Summary: High-density lipoprotein (HDL) particles of larger size and lower levels of H4P are associated with a lower risk of developing type 2 diabetes (T2D), while higher levels of H2P are associated with a higher risk. Additionally, large HDL particles and H6P are inversely associated with T2D in nonobese individuals.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Cardiac & Cardiovascular Systems
Alexandra V. Rozhkova, Veronika G. Dmitrieva, Elena V. Nosova, Alexander D. Dergunov, Svetlana A. Limborska, Liudmila V. Dergunova
Summary: This review summarizes the progress in studying the genomic variants of ABCA1, ABCG1, and SCARB1, and the regulation of their function at transcriptional and post-transcriptional levels in atherosclerosis. Potential biomarkers and targets for atheroprotection based on molecular mechanisms of expression regulation for three transporter genes are also discussed in this review.
JOURNAL OF CARDIOVASCULAR DEVELOPMENT AND DISEASE
(2021)
Review
Health Care Sciences & Services
Jing Wang, Qianqian Xiao, Luyun Wang, Yan Wang, Daowen Wang, Hu Ding
Summary: ABCA1 plays a significant role in cholesterol homeostasis and inflammation inhibition, and decreased expression of ABCA1 is associated with an increased risk of cardiovascular diseases.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Leonor Jacobo-Albavera, Mayra Dominguez-Perez, Diana Jhoseline Medina-Leyte, Antonia Gonzalez-Garrido, Teresa Villarreal-Molina
Summary: ABCA1 plays a crucial role in cholesterol homeostasis, reverse cholesterol transport, lipid content in the plasma membrane, and the development of organ diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Ryoko Shinohata, Misako Shibakura, Yujiro Arao, Shogo Watanabe, Satoshi Hirohata, Shinichi Usui
Summary: A high-fat/high-cholesterol diet increases serum levels of apoE-rich HDL, while a high-cholesterol diet does not. This study investigates the effects of dietary fat and cholesterol on gene expression and HDL production. The results suggest that increased apoE-rich HDL induced by fat and cholesterol may be mediated by increased ABCA1-mediated cholesterol efflux from the liver.
Article
Genetics & Heredity
Ghada M. A. Ajabnoor, Suhad M. Bahijri, Wafa Alrashidi, Sumia Mohammad Enani, Aliaa A. Alamoudi, Lubna Al Sheikh, Basmah Eldakhakhny
Summary: Studies suggest that there is an association between ATP-binding cassette transporter A1 (ABCA1 C69T) gene polymorphism and the risk of type 2 diabetes mellitus (T2DM) and dyslipidemia in diabetic individuals. However, contradictory findings exist. This study aimed to investigate the prevalence of ABCA1 C69T gene polymorphism in a representative sample of the Saudi population and its possible association with dyslipidemia and dysglycemia. The results showed that the T allele of ABCA1 C69T gene polymorphism was associated with dysglycemia but not dysregulation of lipid parameters.
Article
Cardiac & Cardiovascular Systems
Francesca Zimetti, Elda Favari, Paola Cagliero, Maria Pia Adorni, Nicoletta Ronda, Renato Bonardi, Monica Gomaraschi, Laura Calabresi, Franco Bernini, Ornella Guardamagna
Article
Pharmacology & Pharmacy
Livia Pisciotta, Cecilia Vitali, Elda Favari, Paola Fossa, Maria Pia Adorni, Daniela Leone, Nathan Artom, Raffaele Fresa, Laura Calabresi, Sebastiano Calandra, Stefano Bertolini
JOURNAL OF CLINICAL LIPIDOLOGY
(2015)
Article
Cardiac & Cardiovascular Systems
R. Yahya, E. Favari, L. Calabresi, A. J. M. Verhoeven, F. Zimetti, M. P. Adorni, M. Gomaraschi, M. Averna, A. B. Cefalu, F. Bernini, E. J. G. Sijbrands, M. T. Mulder, J. E. Roeters van Lennep
Article
Neurosciences
Francesca Zimetti, Paolo Caffarra, Nicoletta Ronda, Elda Favari, Maria Pia Adorni, Ilaria Zanotti, Franco Bernini, Federica Barocco, Marco Spallazzi, Daniela Galimberti, Chiara Ricci, Massimiliano Ruscica, Alberto Corsini, Nicola Ferri
JOURNAL OF ALZHEIMERS DISEASE
(2017)
Article
Cell Biology
Sara Della Torre, Nico Mitro, Roberta Fontana, Monica Gomaraschi, Elda Favari, Camilla Recordati, Federica Lolli, Fabiana Quagliarini, Clara Meda, Claes Ohlsson, Maurizio Crestani, Nina Henriette Uhlenhaut, Laura Calabresi, Adriana Maggi
Article
Peripheral Vascular Disease
Federico Bigazzi, Maria Pia Adorni, Mariarita Puntoni, Francesco Sbrana, Vincenzo Lionetti, Beatrice Dal Pino, Elda Favari, Fabio A. Recchia, Franco Bernini, Tiziana Sampietro
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2017)
Review
Pharmacology & Pharmacy
Claudia Stefanutti, Ulrich Julius, Gerald F. Watts, Mariko Harada-Shiba, Maria Cossu, Volker J. Schettler, Giustina De Silvestro, Handrean Soran, Jeanine Roeters Van Lennep, Livia Pisciotta, Hans U. Kloer, Kurt Widhalm, Patrick M. Moriarty
JOURNAL OF CLINICAL LIPIDOLOGY
(2017)
Article
Biochemistry & Molecular Biology
Francesca Zimetti, Stefano De Vuono, Monica Gomaraschi, Maria Pia Adorni, Elda Favari, Nicoletta Ronda, Maria Anastasia Ricci, Fabrizio Veglia, Laura Calabresi, Graziana Lupattelli
JOURNAL OF LIPID RESEARCH
(2017)
Article
Cardiac & Cardiovascular Systems
Elda Favari, Michael J. Thomas, Mary G. Sorci-Thomas
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
(2018)
Article
Medicine, General & Internal
L. Calabresi, S. Simonelli, P. Conca, G. Busnach, M. Cabibbe, L. Gesualdo, M. Gigante, S. Penco, F. Veglia, G. Franceschini
JOURNAL OF INTERNAL MEDICINE
(2015)
Article
Cardiac & Cardiovascular Systems
Cinzia Parolini, Maria Pia Adorni, Marco Busnelli, Stefano Manzini, Eleonora Cipollari, Elda Favari, Paolo Lorenzon, Giulia S. Ganzetti, Juergen Fingerle, Franco Bernini, Giulia Chiesa
CANADIAN JOURNAL OF CARDIOLOGY
(2019)
Article
Hematology
Anna E. Bortnick, Petra Buzkova, James Otvos, Majken Jensen, Michael Y. Tsai, Matthew Budoff, Rachel Mackey, Samar R. El Khoudary, Elda Favari, Ryung S. Kim, Carlos J. Rodriguez, George Thanassoulis, Jorge R. Kizer
Summary: This study found that high-density lipoprotein (HDL) cholesterol, HDL particle number and size, apoC3-defined HDL subtypes were inversely associated with the long-term incidence and progression of aortic valve calcification (AVC). Further investigation of HDL composition and mechanisms could be useful in understanding pathways that slow AVC.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Annalisa Ronca, Nicoletta Pellegrini, Giuditta Pagliai, Monica Dinu, Matteo Manfredini, Matteo Incerti, Elda Favari, Francesco Sofi
Summary: This study aimed to evaluate the effect of Mediterranean diet (MD) and lacto-ovo-vegetarian diet (VD) on HDL function in healthy subjects at low-to-moderate cardiovascular disease (CVD) risk. The results showed that MD was more effective than VD in promoting cholesterol efflux and reducing the concentration of pro-atherogenic lipoproteins, suggesting that MD may be a better therapeutic strategy for cardiovascular prevention.
NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES
(2023)
Article
Cardiac & Cardiovascular Systems
Cecilia Vitali, Chiara Pavanello, Marta Turri, Sissel Lund-Katz, Michael C. Phillips, Alberico Luigi Catapano, Andrea Baragetti, Giuseppe Danilo Norata, Fabrizio Veglia, Laura Calabresi
Summary: The present study investigated the ability of different isoforms of apoE to promote LCAT-mediated cholesterol esterification, and found that apoE2 isoform is associated with a higher LCAT-mediated cholesterol esterification.
Article
Cardiac & Cardiovascular Systems
Maria Pia Adorni, Eleonora Cipollari, Elda Favari, Ilaria Zanotti, Francesca Zimetti, Alberto Corsini, Chiara Ricci, Franco Bernini, Nicola Ferri