期刊
BIOCHEMISTRY
卷 48, 期 32, 页码 7565-7567出版社
AMER CHEMICAL SOC
DOI: 10.1021/bi901006b
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资金
- National Institute of General Medical Sciences [GM-063028]
- Johns Hopkins University
- National Institute of Environmental Health Sciences, National Institutes of Health
The DNA interstrand cross-link (ICL) resulting from the C4'-oxidized abasic site (C4-AP) is a unique clustered lesion comprised of a cross-link adjacent to a nick. The ICL is a Substrate for the UvrABC nucleotide excision repair system. The strand containing the nick is preferentially incised.. but the nick influences the cleavage sites. Moreover, in approximately 15% of the molecules, the strand opposite the nick is incised, resulting in a more toxic double-strand break. This is the first example in which an interstrand cross-link is converted by nucleotide excision misrepair into a more deleterious double-strand break.
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