Article
Biochemistry & Molecular Biology
Tomasz Zajkowski, Michael D. Lee, Shamba S. Mondal, Amanda Carbajal, Robert Dec, Patrick D. Brennock, Radoslaw W. Piast, Jessica E. Snyder, Nicholas B. Bense, Wojciech Dzwolak, Daniel F. Jarosz, Lynn J. Rothschild
Summary: The discovery of functional prion-forming domains in archaea expands our knowledge of prions to the third domain of life, suggesting they may have existed at the time of the last universal common ancestor. This study provides evidence that multiple archaeal proteins can act as prions, driving non-Mendelian patterns of inheritance by forming amyloids. The higher tyrosine and phenylalanine content in positively tested candidates may aid in future predictions of archaeal prions.
MOLECULAR BIOLOGY AND EVOLUTION
(2021)
Review
Neurosciences
Asen Daskalov, Nadia El Mammeri, Alons Lends, Jayakrishna Shenoy, Gaelle Lamon, Yann Fichou, Ahmad Saad, Denis Martinez, Estelle Morvan, Melanie Berbon, Axelle Grelard, Brice Kauffmann, Mathias Ferber, Benjamin Bardiaux, Birgit Habenstein, Sven J. Saupe, Antoine Loquet
Summary: This article explores the structures of pathological and functional amyloids, discussing the obtained structural models through techniques such as solid-state NMR. The review concludes with a perspective on integrative approaches to structurally explore various aspects of prion biology.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Anastasia Fomicheva, Eric D. Ross
Summary: Research has shown that stress granules and prions, while both macromolecular assemblies, differ in their physical properties and complexity. Prion aggregates are highly stable homopolymeric solids, while stress granules are complex dynamic biomolecular condensates driven by multivalent homotypic and heterotypic interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Ruben Hervas, Maria del Carmen Fernandez-Ramirez, Albert Galera-Prat, Mari Suzuki, Yoshitaka Nagai, Marta Bruix, Margarita Menendez, Douglas V. Laurents, Mariano Carrion-Vazquez
Summary: The divergent prion-like domains (PLDs) of CPEB proteins from different species retain the ability to form a generic amyloid-like fold through different assembly mechanisms, with structural differences at the beginning of their amyloid assembly pathways.
Article
Chemistry, Multidisciplinary
Hiroki Otaki, Yuzuru Taguchi, Noriyuki Nishida
Summary: This article investigates the relationship between the conformation of PrPSc and hydrophobic amino acids, and finds that subtle differences between these amino acids can greatly affect the stability of PrPSc structures.
Article
Biochemistry & Molecular Biology
Brandon A. Irizarry, Judianne Davis, Xiaoyue Zhu, Baayla D. C. Boon, Annemieke J. M. Rozemuller, William E. Van Nostrand, Steven O. Smith
Summary: Cerebral amyloid angiopathy (CAA) is characterized by the accumulation of fibrillar amyloid-beta (A beta) peptides in or around cerebral blood vessels. Microenvironments play a role in influencing the structure of A beta fibrils, with vascular amyloid fibrils showing a mixture of parallel, in-register, and antiparallel beta-sheet structures, distinct from the structures found in parenchymal amyloid in Alzheimer's disease (AD).
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Kacy R. Paul, Eric D. Ross
Article
Biochemistry & Molecular Biology
Songqing Li, Peipei Zhang, Brian D. Freibaum, Nam Chul Kim, Regina-Maria Kolaitis, Amandine Molliex, Anderson P. Kanagaraj, Ichiro Yabe, Mishie Tanino, Shinya Tanaka, Hidenao Sasaki, Eric D. Ross, J. Paul Taylor, Hong Joo Kim
HUMAN MOLECULAR GENETICS
(2016)
Article
Biochemistry & Molecular Biology
Kacy R. Paul, Amandine Molliex, Sean Cascarina, Amy E. Boncella, J. Paul Taylor, Eric D. Ross
MOLECULAR AND CELLULAR BIOLOGY
(2017)
Article
Genetics & Heredity
Sean M. Cascarina, Kacy R. Paul, Satoshi Machihara, Eric D. Ross
Article
Biochemical Research Methods
Sean M. Cascarina, Eric D. Ross
PLOS COMPUTATIONAL BIOLOGY
(2018)
Review
Genetics & Heredity
Sean M. Cascarina, Eric D. Ross
Review
Genetics & Heredity
Jenifer E. Shattuck, Sean M. Cascarina, Kacy R. Paul, Eric D. Ross
Article
Multidisciplinary Sciences
Jenifer E. Shattuck, Kacy R. Paul, Sean M. Cascarina, Eric D. Ross
NATURE COMMUNICATIONS
(2019)
Article
Biotechnology & Applied Microbiology
Sean M. Cascarina, Eric D. Ross
Article
Multidisciplinary Sciences
Amy E. Boncella, Jenifer E. Shattuck, Sean M. Cascarina, Kacy R. Paul, Matthew H. Baer, Anastasia Fomicheva, Andrew K. Lamb, Eric D. Ross
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2020)
Article
Biochemical Research Methods
Sean M. Cascarina, Mikaela R. Elder, Eric D. Ross
PLOS COMPUTATIONAL BIOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Anastasia Fomicheva, Eric D. Ross
Summary: Research has shown that stress granules and prions, while both macromolecular assemblies, differ in their physical properties and complexity. Prion aggregates are highly stable homopolymeric solids, while stress granules are complex dynamic biomolecular condensates driven by multivalent homotypic and heterotypic interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sean M. Cascarina, Joshua P. Kaplan, Mikaela R. Elder, Lindsey Brookbank, Eric D. Ross
Summary: The degradation sensitivity of G-rich and Q/N-rich domains is influenced by specific sequence features, with G-rich domains being more susceptible to degradation-promoting effects of hydrophobic residues. The proteostasis network may act as a selection mechanism at the molecular level, constraining the sequence space accessible to G-rich domains. However, the sensitivity or resistance of these domains is not always preserved in their native protein contexts, indicating the complexity of protein evolution in overcoming degradation susceptibility.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Sean M. Cascarina, Eric D. Ross
Summary: This article investigates the role of SR-related proteins in the human body. By using an unbiased composition criteria, over 100 putative SR-related proteins were identified, and it was found that they are closely associated with functions such as RNA splicing and nuclear speckles. The newly discovered proteins have slightly different amino acid compositions but similar levels of post-translational modification, indicating their regulation and functional importance in vivo.
Meeting Abstract
Biochemistry & Molecular Biology
Sean Cascarina, Eric Ross