Article
Chemistry, Multidisciplinary
Takashi Nakamura, Sion Elisabeth Elfainatur Haloha, Hideyoshi Harashima
Summary: The combination of polyinosinic-polycytidylic acid (poly I:C) and antigen loaded liposome has been shown to improve cancer immunotherapy and has the potential for effective antitumor immunity. The study investigated the effects of using poly I:C and an antigen loaded liposome for cancer immunotherapy and found that it significantly inhibited systemic cytokine production and improved the immune status in tumors. The findings provide implications for the development of intravenous liposomal vaccines.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Biochemistry & Molecular Biology
Oluyomi Stephen Adeyemi, Abiodun Omokehinde Eseola, Winfried Plass, Kentaro Kato, Chiagoziem A. Otuechere, Oluwakemi Josephine Awakan, Olubunmi Atolani, David Adeiza Otohinoyi, Tobiloba Christiana Elebiyo, Ikponmwosa Owen Evbuomwan
Summary: The study suggests that imidazole compounds restrict parasite growth by causing oxidative stress, making them a potential anti-parasite therapy. This finding not only emphasizes the anti-parasite prospects of imidazoles but also implicates the host L-tryptophan pathway as a feasible treatment option for T. gondii infections.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Multidisciplinary
Jesus Sanjose-Orduna, Rodrigo C. Silva, Fabian Raymenants, Bente Reus, Jannik Thaens, Kleber T. de Oliveira, Timothy Noel
Summary: This study describes a fast, safe, and scalable flow process for the preparation of C-4 alkylated pyridines, involving a photochemical hydrogen atom transfer event and inline removal of blocking group. The key role of benzophenone in the operative reaction mechanism has been revealed through a combination of experimental and computational studies.
Article
Multidisciplinary Sciences
William A. Zeiger, Mate Marosi, Satvir Saggi, Natalie Noble, Isa Samad, Carlos Portera-Cailliau
Summary: The study found no evidence of functional remapping to surviving barrels in the mouse primary somatosensory cortex after stroke, but forced use therapy increased the reliability of C1 whisker-responsive neurons.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Thomas Pokrant, Jens Ingo Hein, Sarah Koerber, Andrea Disanza, Andreas Pich, Giorgio Scita, Klemens Rottner, Jan Faix
Summary: Lamellipodia, actin-based sheet-like membrane protrusions, drive 2D-cell migration, while microspikes are actin-filament bundles embedded within lamellipodia. Ena/VASP proteins and MyoX are found to be essential for microspike formation and their tight functional association in lamellipodia.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Anberitha T. Matthews, Hitesh Soni, Katherine E. Robinson-Freeman, Theresa A. John, Randal K. Buddington, Adebowale Adebiyi
Summary: Doxorubicin (DOX), a chemotherapeutic agent, can induce fetal nephrotoxicity by inhibiting proliferation and inducing death of fetal pig glomerular mesangial cells (GMCs). DOX treatment reduces TRPC6 protein expression, leading to mitochondrial ROS generation and cell death in GMCs. The DOX-induced fetal pig GMC apoptosis is independent of TRPC6 upregulation but requires mtROS production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Sara M. Colom, Regina S. Baucom
Summary: The study investigated the potential of character displacement influencing the evolution of root traits in morning glory species. Evidence suggests that competition environment may impact the role of character convergence or displacement in influencing the evolution of root traits.
Article
Physics, Multidisciplinary
Zhi-Yuan Wei, Daniel Malz, J. Ignacio Cirac
Summary: We introduce a class of states called plaquette projected entangled-pair states, which can be generated in a lattice by applying sequential unitaries to plaquettes of overlapping regions. They exhibit area-law entanglement, have long-range correlations, and generalize other tensor network states. We identify a more efficiently preparable subclass that can be prepared in a radial fashion and includes the family of isometric tensor network states. We also demonstrate the efficient preparation of this subclass using an array of photon sources.
PHYSICAL REVIEW LETTERS
(2022)
Article
Pharmacology & Pharmacy
Arshad Mahmood, Rabbia Haneef, Ahmad Z. Al Meslamani, Mohammad F. Bostanudin, Muhammad Sohail, Muhammad Sarfraz, Mosab Arafat
Summary: The study aims to enhance the oral bioavailability of Acyclovir (ACV) through papain-functionalized self-emulsifying drug delivery systems (SEDDS), which shows promising results in vitro.
Article
Biochemistry & Molecular Biology
Hajime Yaguchi, Itaru Kobayashi, Kiyoto Maekawa, Christine A. Nalepa
Summary: Subsocial Cryptocercus cockroaches, believed to be socially monogamous, were found to have common extra-pair paternity in field-collected families. The study revealed that approximately half of young females exhibit serial monogamy and produce offspring with the last mated male, while pair males extend parental care to unrelated nymphs. This suggests genetic monogamy may not be a strict prerequisite for the evolution of termite eusociality.
Article
Multidisciplinary Sciences
Machhindra Garad, Elke Edelmann, Volkmar Lessmann
Summary: BDNF plays a crucial role in regulating synaptic plasticity, with studies showing a bidirectional mode of action involving different receptors. This study focused on the role of proBDNF/p75NTR signaling in MF-LTD and found that MF-LTD is not dependent on p75 neurotrophin receptors.
SCIENTIFIC REPORTS
(2021)
Article
Psychology, Experimental
Erik Brockbank, Caren M. Walker
Summary: Research has shown that self-explanation improves learning by directing attention and cognitive resources towards evidence that supports good explanations. However, it is unclear whether explanation impacts the learning process through improved hypothesis generation or hypothesis evaluation.
Article
Business
Anne Hamby, Tom van Laer
Summary: The research shows that audiences are more interested in services when characters act for intrinsically motivated reasons in stories, and the consequences of characters' actions further shape audience interest in services. Therefore, characters in stories should have intrinsic motivations and positive consequences to effectively engage consumers in services.
JOURNAL OF SERVICE RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Eduardo Rodrigo, Rainer Wiechert, Magnus W. Walter, Wilfried Braje, Herve Geneste
Summary: By using KOH, the direct F to OH exchange of aromatic and heteroaromatic substrates can be achieved under mechanochemical conditions, making the process more atom economical and environmentally friendly compared to other methods.
Article
Multidisciplinary Sciences
Nadia Paraskevoudi, Iria SanMiguel
Summary: This study found that self-generation does not affect detection and discrimination sensitivity, but there is a significant interaction between self-generation and intensity on perceptual bias in the discrimination task (i.e. Point of Subjective Equality). Supra-threshold self-generated sounds were perceived softer than externally-generated ones, while near-threshold self-generated sounds were perceived louder than externally-generated ones.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Chiara Borsari, Nuno Santarem, Juan Torrado, Ana Isabel Olias, Maria Jesus Corral, Catarina Baptista, Sheraz Gul, Markus Wolf, Maria Kuzikov, Bernhard Ellinger, Gesa Witt, Philip Gribbon, Jeanette Reinshagen, Pasquale Linciano, Annalisa Tait, Luca Costantino, Lucio H. Freitas-Junior, Carolina B. Moraes, Pascoalino Bruno dos Santos, Laura Maria Alcantara, Caio Haddad Franco, Claudia Danielli Bertolacini, Vanessa Fontana, Paloma Tejera Nevado, Joachim Clos, Jose Maria Alunda, Anabela Cordeiro-da-Silva, Stefania Ferrari, Maria Paola Costi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2017)
Review
Oncology
Sheraz Gul
CLINICAL EPIGENETICS
(2017)
Article
Pharmacology & Pharmacy
Reggie Bosma, Gesa Witt, Lea A. I. Vaas, Ivana Josimovic, Philip Gribbon, Henry F. Vischer, Sheraz Gul, Rob Leurs
FRONTIERS IN PHARMACOLOGY
(2017)
Article
Chemistry, Medicinal
Elisa Uliassi, Lorna Piazzi, Federica Belluti, Andrea Mazzanti, Marcel Kaiser, Reto Brun, Carolina B. Moraes, Lucio H. Freitas-Junior, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Chiara Borsari, Maria Paola Costi, Maria Laura Bolognesi
Article
Chemistry, Medicinal
Christina Spry, Alan L. Sewell, Yuliya Hering, Mathew V. J. Villa, Jonas Weber, Stephen J. Hobson, Suzannah J. Harnor, Sheraz Gul, Rodolfo Marquez, Kevin J. Saliba
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Chemistry, Medicinal
Pasquale Linciano, Carolina B. Moraes, Laura M. Alcantara, Caio H. Franco, Bruno Pascoalino, Lucio H. Freitas-Junior, Sara Macedo, Nuno Santarem, Anabela Cordeiro-da-Silva, Sheraz Gul, Gesa Witt, Maria Kuzikov, Bernhard Ellinger, Stefania Ferrari, Rosaria Luciani, Antonio Quotadamo, Luca Costantino, Maria Paola Costi
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2018)
Article
Pharmacology & Pharmacy
Wilhelmus E. A. de Witte, Joost W. Versfelt, Maria Kuzikov, Solene Rolland, Victoria Georgi, Philip Gribbon, Sheraz Gul, Dymphy Huntjens, Piet Hein van der Graaf, Meindert Danhof, Amaury Fernandez-Montalvan, Gesa Witt, Elizabeth C. M. de Lange
BRITISH JOURNAL OF PHARMACOLOGY
(2018)
Article
Multidisciplinary Sciences
Indira Nederpelt, Maria Kuzikov, Wilbert E. A. de Witte, Patrick Schnider, Bruno Tuijt, Sheraz Gul, Adriaan P. IJzerman, Elizabeth C. M. de Lange, Laura H. Heitman
SCIENTIFIC REPORTS
(2017)
Article
Chemistry, Medicinal
Pasquale Linciano, Cecilia Pozzi, Lucia dello Iacono, Flavio di Pisa, Giacomo Landi, Alessio Bonucci, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Gesa Witt, Nuno Santarem, Catarina Baptista, Caio Franco, Carolina B. Moraes, Wolfgang Mueller, Ulrike Wittig, Rosaria Luciani, Antony Sesenna, Antonio Quotadamo, Stefania Ferrari, Ina Pohner, Anabela Cordeiro-da-Silva, Stefano Mangani, Luca Costantino, Maria Paola Costi
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Chemistry, Medicinal
Chiara Borsari, Nuno Santarem, Sara Macedo, Maria Dolores Jimenez-Anton, Juan J. Torrado, Ana Isabel Olias-Molero, Maria J. Corral, Annalisa Tait, Stefania Ferrari, Luca Costantino, Rosaria Luciani, Glauco Ponterini, Sheraz Gul, Maria Kuzikov, Bernhard Ellinger, Birte Behrens, Jeanette Reinshagen, Jose Maria Alunda, Anabela Cordeiro-da-Silva, Maria Paola Costi
ACS MEDICINAL CHEMISTRY LETTERS
(2019)
Article
Biochemical Research Methods
Carolina B. Moraes, Gesa Witt, Maria Kuzikov, Bernhard Ellinper, Theodora Calogeropoulou, Kyriakos C. Prousis, Stefano Mangani, Flavio Di Pisa, Giacomo Landi, Lucia Dello Lacono, Cecilia Pozzi, Lucio H. Freitas-Junior, Bruno dos Santos Pascoalino, Claudia P. Bertolacini, Birte Behrens, Oliver Keminer, Jennifer Leu, Markus Wolf, Jeanette Reinshagen, Anabela Cordeiro-da-Silva, Nuno Santarem, Alberto Venturelli, Stephen Wrigley, Deepa Karunakaran, Bethlehem Kebede, Ina Poehner, Wolfgang Mueller, Joanna Panecka-Hofman, Rebecca C. Wade, Martina Fenske, Joachim Clos, Jose Maria Alunda, Maria Jesus Corral, Elisa Uliassi, Maria Laura Bolognesi, Pasquale Linciano, Antonio Quotadamo, Stefania Ferrari, Matteo Santucci, Chiara Borsari, Maria Paola Costi, Sheraz Gul
Article
Chemistry, Medicinal
Giacomo Landi, Pasquale Linciano, Chiara Borsari, Claudia P. Bertolacini, Carolina B. Moraes, Anabela Cordeiro-da-Silva, Sheraz Gul, Gesa Witt, Maria Kuzikov, Maria Paola Costi, Cecilia Pozzi, Stefano Mangani
ACS INFECTIOUS DISEASES
(2019)
Article
Biochemistry & Molecular Biology
Dagmar E. Ehrnhoefer, Niels H. Skotte, Jeanette Reinshagen, Xiaofan Qiu, Bjorn Windshuegel, Priyadarshini Jaishankar, Safia Ladha, Olga Petina, Mehdi Khankischpur, Yen T. N. Nguyen, Nicholas S. Caron, Adelia Razeto, Matthias Meyer Zu Rheda, Yu Deng, Khuong T. Huynh, Ilka Wittig, Philip Gribbon, Adam R. Renslo, Detlef Geffken, Sheraz Gul, Michael R. Hayden
CELL CHEMICAL BIOLOGY
(2019)
Article
Medicine, Research & Experimental
Ensaf M. Al-Hujaily, Tanvir Khatlani, Zeyad Alehaideb, Rizwan Ali, Bader Almuzaini, Bahauddeen M. Alrfaei, Jahangir Iqbal, Imadul Islam, Shuja Malik, Bader A. Marwani, Salam Massadeh, Atef Nehdi, Barrak Alsomaie, Bader Debasi, Ibraheem Bushnak, Saeed Noibi, Syed Hussain, Wahid Abdul Wajid, Jean-Pierre Armand, Sheraz Gul, Julen Oyarzabal, Rana Rais, Chas Bountra, Ahmed Alaskar, Bander Al Knawy, Mohamed Boudjelal
BIOMEDICAL REPORTS
(2018)
Article
Chemistry, Multidisciplinary
Pasquale Linciano, Alice Dawson, Ina Poehner, David M. Costa, Monica S. Sa, Anabela Cordeiro-da-Silva, Rosaria Luciani, Sheraz Gul, Gesa Witt, Bernhard Ellinger, Maria Kuzikov, Philip Gribbon, Jeanette Reinshagen, Markus Wolf, Birte Behrens, Veronique Hannaert, Paul A. M. Michels, Erika Nerini, Cecilia Pozzi, Flavio di Pisa, Giacomo Landi, Nuno Santarem, Stefania Ferrari, Puneet Saxena, Sandra Lazzari, Giuseppe Cannazza, Lucio H. Freitas-Junior, Carolina B. Moraes, Bruno S. Pascoalino, Laura M. Alcantara, Claudia P. Bertolacini, Vanessa Fontana, Ulrike Wittig, Wolfgang Muller, Rebecca C. Wade, William N. Hunter, Stefano Mangani, Luca Costantino, Maria P. Costi