Review
Pharmacology & Pharmacy
Chengye Zhao, Xunjia Qian, Minni Qin, Xinyang Sun, Qingqing Yu, Jianyu Liu, Qing Zhu, Andong Wang
Summary: This study reveals that Juglans mandshurica has various bioactive metabolites and shows multiple biological activities, including anti-inflammatory, anticancer, and antimicrobial properties. The traditional uses of this plant are also validated to some extent.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2023)
Article
Genetics & Heredity
Xiang Luo, Huijuan Zhou, Da Cao, Feng Yan, Pengpeng Chen, Jiangtao Wang, Keith Woeste, Xin Chen, Zhangjun Fei, Hong An, Maria Malvolti, Kai Ma, Chaobin Liu, Aziz Ebrahimi, Chengkui Qiao, Hang Ye, Mengdi Li, Zhenhua Lu, Jiabao Xu, Shangying Cao, Peng Zhao
Summary: In this study, the authors sequenced 309 walnut accessions from around the world, aiming to better understand the genetic diversity, domestication, and selection footprints in Persian walnuts. The results revealed core areas of genetic diversity and identified transcription factors related to nut diaphragm thickness that were under selection during domestication. This study provides valuable insights for the genomics-assisted breeding of this economically important crop.
Article
Biology
Chonur Mohammadi, Nasrin Seyedi, Babak Abdollahi Mandoulakani, Maria Filomena Caeiro
Summary: The study found that natural populations had higher total number of alleles and observed heterozygosity compared to planted stands, suggesting that genetic diversity of both plantation and natural stands are similar.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2021)
Article
Plant Sciences
Tijana Dordevic, Rada Durovic-Pejcev, Marija Stevanovic, Marija Saric-Krsmanovic, Ljiljana Radivojevic, Ljiljana Santric, Jelena Gajic-Umiljendic
Summary: The study investigated the herbicidal potential of walnut leaf extract against two weeds, Amaranthus retroflexus and Chenopodium album, and evaluated its impact on maize. The results showed that the walnut leaf extract negatively affected the germination and growth of the tested weeds, as well as induced oxidative stress. However, it had a minimal impact on maize and did not cause significant oxidative stress.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Natalia Zurek, Karolina Pycia, Agata Pawlowska, Ireneusz Tomasz Kapusta
Summary: This study investigated the polyphenol composition and biological potential of pollen from male Juglans regia flowers. It identified 24 phenolic compounds in the pollen, some of which were reported for the first time. The pollen showed strong antioxidant and cytotoxic activity, as well as potential anticancer effects on certain cancer cell lines.
Article
Chemistry, Applied
Yi Lin, Xiaogang Peng, Juan Chen, Jia Zhou, Hanli Ruan
Summary: Two new triterpenoids, jughopanes A and jughopanes B, along with seventeen known ones were isolated from the fresh pericarps of Juglans hopeiensis. Compound 7 showed moderate cytotoxicity against MCF7 and HT29 cancer cell lines, indicating its potential as an anticancer agent.
NATURAL PRODUCT RESEARCH
(2021)
Article
Agronomy
Hengzhao Liu, Hang Ye, Jiangtao Wang, Shenqun Chen, Mengdi Li, Gang Wang, Na Hou, Peng Zhao
Summary: In this study, 19 YABBY genes were identified from two Juglans species. Sequence analysis showed that they played important roles in phytohormone and light responses. Gene expression pattern analysis suggested that walnut YABBY genes were likely involved in peel and flower development and responses to biotic stress. This study provided novel insights into the evolutionary basis of YABBY gene families in Juglans and offered clues for further investigation in other tree species.
Article
Agronomy
Fernando Ramirez
Summary: This study examined the relationships between nut length and weight among Juglans neotropica trees in a city park in Bogota, Colombia. Non-destructive and external morphological measurements were used due to the endangered status of the species. The results showed a strong correlation between nut width and weight, and a moderate-strong correlation between nut length and weight. These findings are important for selecting the best plant material for breeding programs in urban forests.
GENETIC RESOURCES AND CROP EVOLUTION
(2022)
Article
Agriculture, Multidisciplinary
Shiyang Zhou, Gangliang Huang
Summary: This study used walnut shells as raw materials to prepare polysaccharides through water extraction and alcohol precipitation methods, and investigated the molecular weight, monosaccharide components, molecular structure characteristics, and antioxidant activities of its derivatives. The study revealed that walnut shell polysaccharides have good biological activities, especially phosphorylated walnut shell polysaccharides. The research on walnut shell polysaccharides has important practical significance for improving the quality and efficiency of the walnut industry chain.
CHEMICAL AND BIOLOGICAL TECHNOLOGIES IN AGRICULTURE
(2023)
Article
Food Science & Technology
Filipa S. Grilo, Selina C. Wang
Summary: Kernel oxidation susceptibility and pellicle darkening are significant concerns for walnut quality. Monitoring oxidation parameters and volatiles in kernels can help evaluate potential oxidation markers. Different storage conditions can impact the oxidative stability, phenols, tocopherols, and fatty acid profiles of walnuts, making kernel volatiles a useful measure for walnut oxidation during storage.
Article
Plant Sciences
Xue-Hua Li, Wei Zhang, Jian-Jun Lei, Jing Tian, He Zhang
Summary: Three new nortriterpenoids, named jugcathenoids A-C (1-3), were isolated from the 90% ethanol extract of the barks of Juglans cathayensis. Their structures were elucidated by spectroscopic analysis. The isolated compounds showed cytotoxic activities against pancreatic tumor cell lines with IC50 values less than 50 mu M.
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH
(2023)
Article
Chemistry, Applied
Ying-Ying Chen, Jiang-Ping Hou, Ling Huang, Afsar Khan, Fei-Fei Xing, Xiao-Han Zhang, De-Feng Han, Shi-Li Yan, Gui-Dong Cao, Qi-Yang Jiao, Dejie Liu, Xuwei Zhu, Qingwen Hu, Hong-Xiang Lou
Summary: A new diarylheptanoid and a new bisabolane-type sesquiterpenoid, along with nineteen known compounds, were isolated from Viscum coloratum. The structures of these compounds were determined using NMR and HRESIMS. The cytotoxic activity of all compounds against eight human tumor cell lines was evaluated.
NATURAL PRODUCT RESEARCH
(2022)
Article
Plant Sciences
Ricardo Alfredo del Barrio, Gustavo Adolfo Orioli, Andrea Soledad Brendel, Lilia Ivone Lindstroem, Cecilia Noemi Pellegrini, Jose Antonio Campoy
Summary: This study presents a multidisciplinary analysis of dormancy progression in walnut trees in northern Patagonia, linking forcing/field phenology, bud anatomical development, and soluble sugar dynamics. The results suggest that heat requirement is the main driver in phenology dynamics, and the decrease in sucrose may serve as a reliable biological marker for endodormancy release in walnut trees.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Horticulture
Valbona Sota, Carla Benelli, Matilda Myrselaj, Efigjeni Kongjika, Nazim S. Gruda
Summary: This research successfully regenerated plantlets from synthetic seeds containing shoot tips of four native walnut varieties, providing a rapid regeneration and ex situ conservation method for this endangered species.
Article
Chemistry, Applied
Yi Lin, Jingjing Liang, Xiaogang Peng, Hanli Ruan
Summary: Three new phenolic compounds were isolated from Juglans sigillata Dode, showing moderate neuroprotective effects in human neuroblastoma SH-SY5Y cell line. These compounds were identified as 2,3,4-trihydroxy-1-(4 '-hydroxybenzyl)benzoic acid, 2,3,4-trihydroxy-1-(4 '-hydroxy-3 '-methoxybenzyl)benzoic acid, and 2-(4 '-hydroxy-3 '-methoxybenzyl)-3,5-dimethoxy-1,4-benzoquinone.
NATURAL PRODUCT RESEARCH
(2021)
Article
Immunology
Xuejing Jia, Chao Zhang, Jiaolin Bao, Kai Wang, Yanbei Tu, Jian-Bo Wan, Chengwei He
INFLAMMOPHARMACOLOGY
(2020)
Article
Agriculture, Multidisciplinary
Yanbei Tu, Kai Wang, Xuejing Jia, Lihua Tan, Bing Han, Qingwen Zhang, Yanfang Li, Chengwei He
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2020)
Article
Plant Sciences
Yanbei Tu, Kai Wang, Lihua Tan, Bing Han, Yuanjia Hu, Hang Ding, Chengwei He
JOURNAL OF ETHNOPHARMACOLOGY
(2020)
Article
Integrative & Complementary Medicine
Lihua Tan, Yanbei Tu, Kai Wang, Bing Han, Hongquan Peng, Chengwei He
Article
Pharmacology & Pharmacy
Bing Han, Kai Wang, Yanbei Tu, Lihua Tan, Chengwei He
Article
Food Science & Technology
Chenggang Han, Hui Zhou, Wei Wu, Xuemei Chen, Huaiping Li, Yanfang Li, DeJian Feng
Summary: A new UPLC-MS/MS method has been developed for investigating various sterols in diversiform food materials, with wider extensive applicability, considered time and cost saving, and improved labor efficiency. The method validation parameters showed that the method was sensitive and accurate enough for analysis.
FOOD ANALYTICAL METHODS
(2021)
Article
Chemistry, Medicinal
Tao Lu, Yi Liu, Yan Liu, Hao Chen, Chengang Han, Xiaoye Feng, Hui Zhou, Yanfang Li
Summary: An integrated computational strategy was used to discover a potential BChE inhibitor through structure-based pharmacophore virtual screening, which showed effectiveness and neuroprotective effects in comparison to tacrine.
FUTURE MEDICINAL CHEMISTRY
(2021)
Review
Pharmacology & Pharmacy
Yanbei Tu, Ying Yang, Yanfang Li, Chengwei He
Summary: This comprehensive review summarizes the chemical structures and diverse pharmacological activities of coumestans isolated from various plant sources, providing important information on their medicinal values and potential for the rational design and development of more effective drugs. The focus on the counteraction of coumestans against bone diseases and organ damages, along with the involved molecular mechanisms, offers insights into the therapeutic potential of these compounds.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yan Liu, Chenggang Han, Tao Lu, Yi Liu, Hao Chen, Can Yang, Yanbei Tu, Yanfang Li
Summary: Chrysoeriol (CHE), a natural flavone, shows potent Xanthine oxidase (XO) inhibitory activity through competitive inhibition with hydrogen bonding and hydrophobic interaction. The interaction between CHE and XO was studied through fluorescence quenching and conformational changes, revealing the binding mechanism of CHE towards XO. Molecular docking study enhanced the understanding of CHE's binding affinity towards XO, while molecular dynamic simulation and ADMET prediction showed promising stability and pharmacokinetic properties of CHE.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Pharmacology & Pharmacy
Yanbei Tu, Lihua Tan, Tao Lu, Kai Wang, Haiyong Wang, Bing Han, Yuxin Zhao, Hanbin Chen, Yanfang Li, Haixia Chen, Meiwan Chen, Chengwei He
Summary: The newly reported coumestan Glytabastan B (GlyB) from Glycine tabacina has been found to effectively attenuate inflammation and bone destruction in rheumatoid arthritis. It works by blocking the activation of multiple signaling pathways.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Dan Zhang, Sifan Wang, Fangxi Yang, Qingrong Qi, Yanfang Li, Wencai Huang
Summary: The responses of the reaction-based fluorescent probe BI-Py towards various chemical compounds were evaluated, and it selectively detected ethyl triflate in acetonitrile with a LOD of 1.08 μM. BI-Py showed great potential for the detection of triflate as a genotoxic impurity in drug substances.
CHEMICAL COMMUNICATIONS
(2023)
Article
Chemistry, Multidisciplinary
Pei He, Haiqi Xu, Can Yang, Dehong Yu, Yi Liu, Jiana Du, Yanfang Li
Summary: This study elucidated the inhibitory mechanism of AUR on XO for the first time, providing fresh insights into its further development as a natural potent XO inhibitor with an aurone skeleton.
Article
Biochemistry & Molecular Biology
Ruidang Yang, Bijian He, Shengqi Zhang, Ruifeng Mei, Jiaqi Liu, Tianpeng Yin, Le Cai
Summary: In this study, the phytochemical analysis of Asparagus lycopodineus was conducted for the first time, leading to the isolation of 14 compounds. Among them, five compounds have never been found in the Asparagus genus before. Additionally, the results highlight the close evolutionary relationship among A. lycopodineus, A. cochinchinensis, and A. filicinus.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2024)
