Article
Chemistry, Multidisciplinary
Ye Chang, Zhi-Kang Duan, Xin Zhang, Jiao-Yang Hou, Jia-Qi Niu, Guo-Dong Yao, Bin Lin, Shao-Jiang Song, Ming Bai, Xiao-Xiao Huang
Summary: Six pairs of enantiomeric dihydrobenzofuran-type lignanamides were isolated from Solanum lyratum, along with a previously undescribed racemic mixture. The structures of these undescribed compounds were determined through analysis of spectroscopic data and circular dichroism method. Neuroprotective and acetylcholinesterase inhibitory activities were evaluated for all isolated compounds, and compound 3b exhibited significant neuroprotective activity, while compounds 2b, 4a, 6a, and 6b showed moderate neuroprotective effects.
NEW JOURNAL OF CHEMISTRY
(2023)
Review
Nutrition & Dietetics
Beata Olas
Summary: Schisandra chinensis berries are valuable agents in modern phototherapy with anti-cancer, hepatoprotective, anti-inflammatory, and antioxidant properties. The unique chemical composition of these berries, particularly their lignan content, contributes to their therapeutic potential. The selected lignans, including schisandrin, schisandrin B, schisantherin A, schisantherin B, schisanhenol, deoxyschisandrin, and gomisin A, possess cardioprotective properties.
Review
Plant Sciences
Dunja Samec, Erna Karalija, Ivana Sola, Valerija Vujcic Bok, Branka Salopek-Sondi
Summary: Abiotic stressors such as extreme temperatures, drought, flood, light, salt, and heavy metals can affect biological diversity and crop production. Plants have mechanisms to cope with these stressors, and polyphenols, a group of plant-specialized metabolites, play a role in stress protection. Different polyphenol structures have varying biological activities and roles in abiotic stress responses.
Review
Biochemistry & Molecular Biology
Francesco Limongelli, Pasquale Crupi, Maria Lisa Clodoveo, Filomena Corbo, Marilena Muraglia
Summary: Salicornia, a halophyte plant abundant on Mediterranean coast, is not only used as a seasoned vegetable, but also in traditional medicine for protecting against diseases such as obesity, diabetes, and cancer. Its high level of polyphenols, particularly the antioxidant and antiradical activity, make it a potential functional food candidate with beneficial activities for human health.
Article
Chemistry, Multidisciplinary
Usama Ramadan Abdelmohsen, Soad A. L. Bayoumi, Nesma M. Mohamed, Yaser A. Mostafa, Che J. Ngwa, Gabriele Pradel, Salwa F. Farag
Summary: Malaria is a dangerous parasitic disease, and new antimalarial drugs are urgently needed. Natural products, particularly phenylpropanoids, have shown potential as antimalarial agents. In this study, in silico analysis and in vitro assays were conducted to assess the antimalarial activity of naturally-occurring phenylpropanoids.
Article
Food Science & Technology
Francisca Hernandez, Lucia Andreu-Coll, Andreia Bento-Silva, Ana Teresa Serra, Pedro Mena, Pilar Legua, Maria Rosario Bronze
Summary: This research analyzed the phytochemical profile of prickly pear fruits from the 'Orito' cultivar under different storage conditions. The study found that some compounds increased in content under cold storage conditions, while there were no significant differences under shelf-life conditions.
Article
Chemistry, Applied
Van-Tuan Vu, Qi-Qi Xu, Huu Tung Nguyen, Ngoc-Hieu Nguyen, Giang-Nam Pham, Ling-Yi Kong, Jian-Guang Luo
Summary: Patulinervones A and B, two diastereomers of spiro-lignans with unique structures, were isolated from the leaves of Melicope patulinervia. They showed inhibitory effects on alpha-glucosidase.
NATURAL PRODUCT RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hui-li Zheng, Meng-ting Li, Tong Zhou, Ying-yi Wang, Er-Xin Shang, Yong-qing Hua, Jin-ao Duan, Yue Zhu
Summary: This study investigated the preventive effect of Lycium barbarum L. berry extract on age-related macular degeneration (AMD) and identified the main components responsible for its antioxidant activity. The results showed that the extracts of L. barbarum berries improved retinal structural abnormalities and attenuated oxidative stress and inflammatory imbalance. Metabolomics analysis revealed that the water extract of L. barbarum berries regulated the metabolism of unsaturated fatty acids and sphingolipids, while the alcohol extract tended to regulate taurine metabolism. Furthermore, it was found that the water extract eluted with 95% ethanol was the vital antioxidant activity fraction.
Article
Chemistry, Applied
Jaggaiah N. Gorantla, Sunaree Choknud, Eko Suyanto, Htun-Htun Win, Yanling Hua, Maniganda Santhi, Sirilak Wangngae, Anyanee Kamkaew, Mariena Ketudat-Cairns, Lalida Rojanathammanee, James R. Ketudat Cairns
Summary: In this study, various hydroxycinnamic and hydroxybenzoic acids were easily converted to phenolic amides (PAMs) through a one-step BOP-mediated amide coupling reaction. Fifteen PAMs were synthesized with yields above 40% and evaluated for cytotoxic activities against four cancer cell lines. Four amides exhibited promising IC50 values ranging from 5 to 55 μM, while tetradecyl-gallic-amide (13) specifically showed significant inhibitory effects on THP-1 leukemia cells with an IC50 value of 3.08 μM. These findings highlight the potential of phenolic amides as anticancer agents.
NATURAL PRODUCT RESEARCH
(2023)
Review
Agronomy
Yachana Jha, Heba I. Mohamed
Summary: Plants have a wide variety of metabolites that enable them to carry out complex metabolic pathways under normal and stressful conditions. These metabolites are divided into primary metabolites, which are essential for the survival of plants, and secondary metabolites, which are involved in the plant's ability to interact with the environment. Secondary metabolites serve as defense compounds against herbivores and microorganisms, and also attract animals for pollination and seed dispersal.
Article
Plant Sciences
Xiaowen Wang, Yue Zhao, Xueqi Dong, Xile Wu, Hai-Yang Yu, Li-Hua Zhang, Lifeng Han, Yi Zhang, Tao Wang, Hong-Hua Wu
Summary: Sixteen non-steroidal compounds were isolated from Solanum lyratum, including a new lignan, a new natural amide compound, and two known lignans. Compound 3 and 6 showed significant inhibitory effects on the activities of HepG2 liver cancer cells.
PHYTOCHEMISTRY LETTERS
(2021)
Article
Chemistry, Organic
Zhiyu Gao, Li Ren, Ruizhi Wang, Liang Shi, Yanhai Wang, Feng Su, Hong-Dong Hao
Summary: An intramolecular formal [3 + 2] cationic cycloaddition was used to synthesize codonopiloneolignanin A, and benzocycloheptene was identified as a good substrate for 1,3-dipolar cycloaddition. A model study was conducted to explore the synthesis of cephalocyclidine A skeleton.
Article
Chemistry, Organic
Jongyeol Han, Hosam Choi, Joohee Choi, Kiyoun Lee
Summary: The first total synthesis of tetrahydrofuran dilignangymnothelignan K is achieved by implementing an early stage one-carbon homologative lactonization for constructing the necessary scaffold and stereo-centers, along with acid-promoted dimerization and Suzuki-Miyaura cross-coupling reaction to install the challenging diaryl skeleton.
Article
Nutrition & Dietetics
Renata A. Carnauba, Flavia M. Sarti, Neuza M. A. Hassimotto, Franco M. Lajolo
Summary: This study estimated the polyphenol intake and major food sources in the Brazilian population using data from the National Dietary Survey. The results showed an increase in polyphenol intake over the past decade in Brazil, but still lower compared to other populations. The main food sources of polyphenols also showed some variations.
BRITISH JOURNAL OF NUTRITION
(2023)
Article
Nutrition & Dietetics
Renata A. Carnauba, Neuza M. A. Hassimotto, Franco M. Lajolo
Summary: This study estimated total and individual polyphenol intakes in a representative sample of the Brazilian population and identified major dietary contributors. Results showed that non-alcoholic beverages and fruits were the main suppliers of polyphenols, with coffee and orange juice being the main contributors. The study also highlighted the need for improved dietary quality in the Brazilian population for better health outcomes.
BRITISH JOURNAL OF NUTRITION
(2021)
Article
Biophysics
Yuqiong Xia, Mei Fang, Jingyu Dong, Chunzhong Xu, Zhen Liao, Pengbo Ning, Qi Zeng
COLLOIDS AND SURFACES B-BIOINTERFACES
(2018)
Article
Nanoscience & Nanotechnology
Hanrui Li, Ke Li, Yunpeng Dai, Xinyi Xu, Xu Cao, Qi Zeng, Huyulong He, Liaojun Pang, Jimin Liang, Xueli Chen, Yonghua Zhan
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2018)
Review
Biochemistry & Molecular Biology
Nan Wang, Honghao Cao, Lin Wang, Feng Ren, Qi Zeng, Xinyi Xu, Jimin Liang, Yonghua Zhan, Xueli Chen
CURRENT MEDICINAL CHEMISTRY
(2020)
Article
Nanoscience & Nanotechnology
Xinyi Xu, Hanrui Li, Ke Li, Qi Zeng, Yin Liu, Yun Zeng, Dan Chen, Jimin Liang, Xueli Chen, Yonghua Zhan
NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Dan Chen, Weian Wang, Yaqin Wu, Hui Xie, Linfei Zhao, Qi Zeng, Yonghua Zhan
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Review
Nanoscience & Nanotechnology
Xiaoxia Cai, Qingxia Zhu, Yun Zeng, Qi Zeng, Xueli Chen, Yonghua Zhan
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2019)
Review
Pharmacology & Pharmacy
Tianyu Yan, Qi Zeng, Lin Wang, Nan Wang, Honghao Cao, Xinyi Xu, Xueli Chen
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Plant Sciences
Qi Zeng, Yun Zeng, Xu Nie, Yingying Guo, Yonghua Zhan
Article
Nanoscience & Nanotechnology
Shenghan Ren, Lin Wang, Qi Zeng, Duofang Chen, Xueli Chen, Jimin Liang
Article
Nanoscience & Nanotechnology
Shenghan Ren, Tianyu Yan, Lin Wang, Nan Wang, Jimin Liang, Qi Zeng, Xueli Chen
Article
Plant Sciences
Qi Zeng, Xu Nie, Li Li, Hui-Fang Liu, Yang-Yao Peng, Wang-Ting Zhou, Xiao-Jia Hu, Xin-Yi Xu, Xue-Li Chen
Summary: Salidroside (Sal) enhances the inhibitory activity of doxorubicin (DOX) in drug-resistant cancer cell lines by regulating the expression of multiple proteins. This study suggests that Sal could be a novel chemosensitization agent for the treatment of multi-drug-resistance tumors.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Multidisciplinary Sciences
Nan Wang, Xinyu Wang, Tianyu Yan, Hui Xie, Lin Wang, Feng Ren, Dan Chen, Dongjie Zhang, Qi Zeng, Shouping Zhu, Xueli Chen
Summary: In this study, a dual-modality optical-Raman projection tomography (ORPT) technology was proposed, which enables label-free three-dimensional imaging of microstructures and components with a micron-level spatial resolution on the same device. Through validation experiments, it was demonstrated that the proposed technology could achieve fused three-dimensional images of the microstructure and molecular components of bio-samples, providing the potential for bimodal label-free volumetric imaging of the structure and function of biomolecules in large samples.
Article
Chemistry, Multidisciplinary
Hanrui Li, Ke Li, Qi Zeng, Yun Zeng, Dan Chen, Liaojun Pang, Xueli Chen, Yonghua Zhan
Article
Chemistry, Multidisciplinary
Fan Yang, Jun Liu, Xue Jiang, Weiwei Wu, Zhenni Wang, Qi Zeng, Ruichan Lv
Article
Chemistry, Multidisciplinary
Qi Zeng, Hongjin Song, Xinyi Xu, Wenjie Mao, Hui Xie, Jimin Liang, Xueli Chen, Dan Chen, Yonghua Zhan
Article
Biochemistry & Molecular Biology
Ruidang Yang, Bijian He, Shengqi Zhang, Ruifeng Mei, Jiaqi Liu, Tianpeng Yin, Le Cai
Summary: In this study, the phytochemical analysis of Asparagus lycopodineus was conducted for the first time, leading to the isolation of 14 compounds. Among them, five compounds have never been found in the Asparagus genus before. Additionally, the results highlight the close evolutionary relationship among A. lycopodineus, A. cochinchinensis, and A. filicinus.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2024)
