Article
Plant Sciences
Luis Francisco Salome-Abarca, Thomas van der Toorn, Rogier van Vugt, Peter G. L. Klinkhamer, Young Hae Choi
Summary: The study investigated the chemical composition of latex and its antiherbivory activity, finding that latexes from different species had similar chemical profiles but higher mortality rates against thrips. The main metabolites correlated with antiherbivory activity were triterpenoids and steroids.
Article
Plant Sciences
Lucas Mesquita Barreto, Rafael De Assis, Andre Luis Laforga Vanzela
Summary: This study investigated the karyotype diversity and DNA C values of Dorstenia spp. from the Neotropical region and examined the genomic sequencing of African and Neotropical species. The results showed that polyploidy plays a significant role in karyotype differentiation, but there is no clear relationship between DNA C values and karyotype features or rDNA sites. Dysploidy events and rearrangements involving repetitive fractions are suggested to be responsible for chromosome number variations and changes in genome size.
BOTANICAL JOURNAL OF THE LINNEAN SOCIETY
(2023)
Article
Chemistry, Multidisciplinary
Mai Hussin Radi, Riham A. A. El-Shiekh, Ali M. M. El-Halawany, Ahmed M. M. Al-Abd, Essam Abdel-Sattar
Summary: This study evaluated the antiproliferative activity of E. grantii aerial parts, and found that the dichloromethane fraction showed promising cytotoxic activity against breast cancer cell lines. Eight compounds were isolated from the active fraction, and euphylbenzoate exhibited the best anticancer activity. These results demonstrate that E. grantii aerial parts contain active compounds with significant antiproliferative potential.
Article
Biochemistry & Molecular Biology
Fabiola A. Lopez-Huerta, Maria Teresa Ramirez-Apan, Carlos A. Mendez-Cuesta, Antonio Nieto-Camacho, Simon Hernandez-Ortega, Ericka K. P. Almeida-Aguirre, Marco A. Cerbon, Guillermo Delgado
Summary: The semisynthesis of novel derivatives of lupeol palmitate and 3 beta-palmitoyloxy-olean-12-ene was conducted, and their cytotoxic and anti-inflammatory activities were evaluated. Several derivatives showed significant inhibition of tumor cell lines, and the modification of compound structure affected their anti-inflammatory activity. Further investigation revealed that compounds 7, 10, and 11 may exert their effects by binding to the NF-kappa B receptor, and these compounds have potential for further research.
BIOORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
HtooTint Wai, Glenn C. Micalizio
Summary: Efforts to establish a concise synthesis of 7,11-dideoxy-Delta 5-lucidadone H have resulted in the successful development of a method utilizing metallacycle-mediated annulative cross-coupling and stereoselective bond formation. Key transformations such as formal inversion of C13 and rearrangement were crucial for this synthesis.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Organic
HtooTint Wai, Glenn C. Micalizio
Summary: Efforts to establish an asymmetric entry to hexanorlanostanes resulted in a concise synthesis of 7,11-dideoxy-Delta 5-lucidadone H from epichlorohydrin. By utilizing metallacycle-mediated annulative cross-coupling and stereoselective formation, key transformations were achieved, including the inversion of the C13 quaternary center and Lewis acid mediated rearrangement, leading to the generation of a hexanorlanostane system.
JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Multidisciplinary Sciences
Chia-Rong Chuang, Chia-Lun Hsieh, Chi-Shan Chang, Chiu-Mei Wang, Danilo N. Tandang, Elliot M. Gardner, Lauren Audi, Nyree J. C. Zerega, Kuo-Fang Chung
Summary: The Taiwanese "breadfruit" is not the same species as the Pacific breadfruit. Phylogenomic analysis shows that the Taiwanese "breadfruit" forms a distinct clade with the A. treculianus complex in the Philippines, indicating it was likely transported from the Philippines to Lanyu by the Yami ancestors. This research helps to correct the misidentification of this important tree species in Taiwan.
Article
Plant Sciences
Wenge Zhang, Xiuxiang Lu, Luqiong Huo, Sha Zhang, Yan Chen, Zhenxing Zou, Haibo Tan
Summary: Chemical investigation of the EtOAc extract from the endophytic fungus Eutypella scoparia SCBG-8 resulted in the isolation of several new sesquiterpenes and steroids, one of which, compound 7, exhibited antibacterial activity against S. aureus and MRSA with MIC values of 6.3 μg/mL.
JOURNAL OF NATURAL PRODUCTS
(2021)
Review
Pharmacology & Pharmacy
Young-A Heo
Summary: A topical gel containing birch bark extract and sunflower oil has been approved in the EU and UK for the treatment of partial thickness wounds. Birch bark extract can accelerate wound healing, improve wound burden and symptoms. Current evidence suggests it is an effective and emerging treatment option.
Review
Pharmacology & Pharmacy
Young-A Heo
Summary: Birch bark extract is an effective treatment option for patients with dystrophic and junctional EB, as it accelerates wound healing and improves wound burden.
Article
Biochemistry & Molecular Biology
Gabriela Pinon-Zarate, Fernanda Reyes-Riquelme, Ma Beatriz Sanchez-Monroy, Monica Velasco-Torrez, Mariano Martinez-Vazquez, Christian Adrian Cardenas-Monroy, Beatriz Hernandez-Tellez, Katia Jarquin-Yanez, Miguel Angel Herrera-Enriquez, Andres Eliu Castell-Rodriguez
Summary: The study found that 3 alpha-OH MDA can induce dendritic cell maturation, inhibit tumor growth, and lead to an expanded cell death area within tumors. This suggests that 3 alpha-OH MDA may be a beneficial molecule for the immune system. Conversely, MDA may have anti-inflammatory properties.
Article
Pharmacology & Pharmacy
Zuzanna Rzepka, Ewa Bebenek, Elwira Chrobak, Dorota Wrzesniok
Summary: The synthesized new 28-indole-betulin derivatives showed promising anticancer activity, particularly against MCF-7 breast cancer cells, possibly through inducing apoptosis.
Review
Chemistry, Medicinal
Rodrigo de Souza Miranda, Barbara da Silva Mascarenhas de Jesus, Sandra Regina da Silva Luiz, Cristina Borges Viana, Camila Rodrigues Adao Malafaia, Fabiana de Souza Figueiredo, Tatiane dos Santos Conceicao Carvalho, Matheus Lopes Silva, Vinicius Silva Londero, Thais Alves da Costa-Silva, Joao Henrique Ghilardi Lago, Roberto Carlos Campos Martins
Summary: This review provides an overview of the anti-inflammatory effects of various triterpenes and their presumed mechanisms of action, based on articles published in the last 15 years. The findings suggest that triterpenes could be valuable natural products with potential pharmaceutical applications.
PHYTOTHERAPY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Bruna Longo, Ellen Perfoll Sommerfeld, Rita de Cassia Melo Vilhena de Andrade Fonseca da Silva, Lincon Bordignon Somensi, Luisa Nathalia Bolda Mariano, Thaise Boeing, Sergio Faloni de Andrade, Priscila de Souza, Luisa Mota da Silva
Summary: This study found that eugenol can accelerate gastric healing process in rats at appropriate doses, showing potential antiulcer effects. However, high doses of eugenol may worsen gastric ulcers.
CHEMICO-BIOLOGICAL INTERACTIONS
(2021)
Article
Chemistry, Medicinal
Marielle Cascaes Inacio, Tiago Antunes Paz, E. M. Kithsiri Wijeratne, G. M. Kamal B. Gunaherath, Rafael V. C. Guido, A. A. Leslie Gunatilaka
Summary: Celastroloids and their derivatives showed significant antibacterial and antifungal activities against bacteria and yeast. Quinonemethide-type celastroloids and phenolic triterpenes exhibited high activity. Some compounds showed antimicrobial activity at sub-cytotoxic concentrations, suggesting their potential as candidates for further studies.
MEDICINAL CHEMISTRY RESEARCH
(2022)
Article
Chemistry, Applied
Manzura A. Agzamova, Nilufar Z. Mamadalieva, Andrea Porzel, Hidayat Hussain, Mthandazo Dube, Katrin Franke, Abdulaziz Janibekov, Ludger A. Wessjohann
Summary: In this study, a new cycloartane triterpene glycoside, named lehmanniaside, was isolated and identified from the aerial parts of Astragalus lehmannianus Bunge. Its structure was determined through spectroscopic analysis, and it exhibited weak anthelmintic, antifungal, and cytotoxic activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Applied
Iliassou Lah Mouafon, Bel Youssouf Gbetnkom Mountessou, Mehreen Lateef, Joseph Tchamgoue, Muhammad Shaiq Ali, Jean Claude Tchouankeu, Ivan Robert Green, Bonaventure Tchaleu Ngadjui, Simeon Fogue Kouam
Summary: Phytochemical investigation of a previously unstudied species of Indigofera led to the isolation of two new phenolic compounds, as well as the identification of nine known secondary metabolites. Antibacterial activity was observed for compounds 7 and 9, and compound 9 showed potent inhibition of the enzyme urease.
NATURAL PRODUCT RESEARCH
(2023)
Article
Plant Sciences
Nadine Tseme Wandji, G. Thierry Mbahbou Bitchagno, Joseph Tchamgoue, Hans-Georg Stammler, Marcel Frese, Bruno Ndjakou Lenta, Norbert Sewald, Simeon Fogue Kouam
Summary: Two furanocoumarin derivatives and nine known compounds were isolated from the twigs of Ficus chlamydocarpa. These compounds showed antibacterial activity against bacterial strains and cytotoxicity towards human cervical carcinoma cell line KB-3-1.
PHYTOCHEMISTRY LETTERS
(2022)
Editorial Material
Biochemistry & Molecular Biology
Hidayat Hussain
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Plant Sciences
Haidy A. Gad, Elbek A. Mukhammadiev, Gokhan Zengen, Nawal M. Al Musayeib, Hidayat Hussain, Ismail Bin Ware, Mohamed L. Ashour, Nilufar Z. Mamadalieva
Summary: The chemical composition and antioxidant and enzyme inhibitory activity of the essential oils from Stachys byzantina, S. hissarica, and S. betoniciflora in Uzbekistan were analyzed.
Article
Biology
Nilufar Z. Mamadalieva, Hidayat Hussain, Adriano Mollica, Gokhan Zengin, Rano Z. Mamadalieva, Sameh S. Elhady, Sana A. Fadil, Mohamed L. Ashour, Fadia S. Youssef
Summary: This study assessed the enzyme inhibitory activity of 20 ecdysteroids and found that they have potential as drug entities for alleviating several disorders. The results indicate that these substances may be helpful in treating various diseases.
Article
Biochemistry & Molecular Biology
Ismail Ware, Katrin Franke, Hidayat Hussain, Ibrahim Morgan, Robert Rennert, Ludger A. Wessjohann
Summary: Peperomia obtusifolia is an ornamental plant native to Middle America, known for its mild antimicrobial properties. Chemical investigation of its leaves led to the discovery of two new compounds and five known compounds. Peperoside showed promising activity against cancer cells and bacteria, but no anthelmintic activity.
Review
Biochemistry & Molecular Biology
Muhammad Imran Tousif, Mamona Nazir, Muhammad Saleem, Saba Tauseef, Nusrat Shafiq, Laiba Hassan, Hidayat Hussian, Domenico Montesano, Daniele Naviglio, Gokhan Zengin, Ishtiaq Ahmad
Summary: This article provides an overview of Psidium guajava L. and its bioactive secondary metabolites, highlighting their health benefits and potential industrial applications. Research has shown that Psidium guajava L., known for its delicious fruit, is also rich in nutrients and phytochemicals that have beneficial effects against chronic diseases. The article emphasizes the importance of long-term clinical trials to explore the potential use of Psidium guajava L. in treating different diseases.
Review
Biochemistry & Molecular Biology
Hidayat Hussain, Jianbo Xiao, Akbar Ali, Ivan R. Green, Bernhard Westermann
Summary: This review categorizes and discusses 180 new unusual cyclized triterpenoids, along with their demonstrated biogenetic pathways, syntheses, and biological effects, published between 2009 and 2021. The research showcases significant advances in the field of triterpenes, with a notable increase in the discovery of cyclized triterpenoids and significant progress in their synthesis and biological activities.
NATURAL PRODUCT REPORTS
(2023)
Review
Plant Sciences
Bel Youssouf G. Mountessou, Joseph Tchamgoue, Iliassou L. Mouafon, Ivan R. Green, Muhammad I. Choudhary, Simeon F. Kouam
Summary: The genus Allanblackia includes ten species of flowering plants that grow in the rainforests of West, Central, and East Africa. These evergreen, medium-sized trees have the largest fruits in the African rainforest, and their stem barks are reddish-brown with small scales. The plants are used in traditional medicine and their seed oils have commercial potential. Chemical analysis has shown that xanthones and biflavonoids are major secondary metabolites in this genus. Some species have exhibited antimicrobial, antileishmanial, anticholinesterase, and cytotoxic activities, making them valuable for new drug discovery.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Article
Chemistry, Multidisciplinary
Amjad Hussain, Faisal Attique, Syed Ali Raza Naqvi, Akbar Ali, Muhammad Ibrahim, Hidayat Hussain, Fatiqa Zafar, Rana Saqib Iqbal, Muhammad Adnan Ayub, Mohammed A. Assiri, Muhammad Imran, Shaheed Ullah
Summary: In this study, a nanoformulation of Curcuma longa L. plant extract was prepared to enhance its dissolution potential and biological activities. The nanosuspensions were formulated using different stabilizers, with sodium lauryl sulfate (SLS) showing the best results. The optimized nanosuspension had an average particle size of 308.2 nm and a dissolution rate of 192.32 μg/mL at pH = 7.
Review
Biochemistry & Molecular Biology
Boris Yotta Kianfe, Joseph Tchamgoue, Abolfazl Narmani, Remy Bertrand Teponno, Andre-Ledoux Njouonkou, Marc Stadler, Simeon Fogue Kouam
Summary: Cytospora is a genus of fungi that can produce diverse secondary metabolites with a broad range of biological activities, making it a prolific source of specialized metabolites. Previous studies have identified and elucidated the structures of several bioactive compounds from this genus, including cytosporones, nonanolides, macrocyclic dilactones, and terpenoids. This review provides a comprehensive summary of the chemical diversity of bioactive secondary metabolites from the genus Cytospora and highlights its potential as an alternative source for pharmacological studies. It also serves as a foundation for future investigations into compounds from this genus.
Article
Chemistry, Organic
Bel Youssouf G. Mountessou, Elodie Gisele M. Anoumedem, Blondelle M. Kemkuignou, Yasmina Marin-Felix, Frank Surup, Marc Stadler, Simeon F. Kouam
Summary: A new species of Diaporthe cameroonensis was isolated from the fresh root of Trema guineensis (Ulmaceae). The strain was fermented and extracted, resulting in the isolation of a hemiketal polyketide and an acetylated alternariol, as well as fifteen known secondary metabolites.
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
(2023)
Article
Microbiology
Blondelle Matio Kemkuignou, Christopher Lambert, Marc Stadler, Simeon Kouam Fogue, Yasmina Marin-Felix
Summary: Four unprecedented polyketides were isolated from the newly described endophytic fungus Diaporthe africana. The fungus was taxonomically identified using a polyphasic approach. The structures of the compounds were determined by spectral analysis, and their antimicrobial and cytotoxic properties were evaluated.
Article
Biochemistry & Molecular Biology
Nadine Tseme Wandji, Gabin Thierry M. Bitchagno, Isabelle Mawabo Kamga, Joseph Tchamgoue, Celine Nguefeu Nkenfou, Bruno Ndjakou Lenta, Norbert Sewald, Simeon Fogue Kouam
Summary: Four polyoxygenated stigmastanes, along with known analogues and flavonoids, were isolated from the whole plant of Vernonia kotschyana. Their structures were determined through spectroscopic and spectrometric analysis. The antibacterial activity of the crude extract, fractions, and compounds was evaluated against prevalent bacterial strains, showing low to moderate activity.
Article
Biochemistry & Molecular Biology
Ruidang Yang, Bijian He, Shengqi Zhang, Ruifeng Mei, Jiaqi Liu, Tianpeng Yin, Le Cai
Summary: In this study, the phytochemical analysis of Asparagus lycopodineus was conducted for the first time, leading to the isolation of 14 compounds. Among them, five compounds have never been found in the Asparagus genus before. Additionally, the results highlight the close evolutionary relationship among A. lycopodineus, A. cochinchinensis, and A. filicinus.
BIOCHEMICAL SYSTEMATICS AND ECOLOGY
(2024)
