Protein kinase Cθ: the pleiotropic T-cell signalling intermediate

Loss of Protein Kinase C , Bcl10, or Malt1 Selectively Impairs Proliferation and NF- B Activation in the CD4+ T Cell Subset

(2014) L. M. Kingeter et al.   JOURNAL OF IMMUNOLOGY

A Critical Role for Protein Kinase C- -Mediated T Cell Survival in Cardiac Allograft Rejection

(2014) S. Manicassamy et al.   JOURNAL OF IMMUNOLOGY

Protein Kinase C θ Regulates the Phenotype of Murine CD4+ Th17 Cells

(2014) Katarzyna Wachowicz et al.   PLoS One

Pharmacologic inhibition of PKC  and PKC  prevents GVHD while preserving GVL activity in mice

(2013) K. M. K. Haarberg et al.   BLOOD

Essentials of Th17 cell commitment and plasticity

(2013) P. Muranski et al.   BLOOD

TNFa alter cholesterol metabolism in human macrophages via PKC-theta-dependent pathway

(2013) A Zhi Sha Ma et al.   BMC BIOCHEMISTRY

The Kinase PKCα Selectively Upregulates Interleukin-17A during Th17 Cell Immune Responses

(2013) Marlies Meisel et al.   IMMUNITY

Early signaling events that underlie fate decisions of naive CD4+T cells toward distinct T-helper cell subsets

(2013) Hidehiro Yamane et al.   IMMUNOLOGICAL REVIEWS

In and out of the bull's eye: protein kinase Cs in the immunological synapse

(2013) Kok-Fai Kong et al.   TRENDS IN IMMUNOLOGY

Low dose CP-690,550 (tofacitinib), a pan-JAK inhibitor, accelerates the onset of experimental autoimmune encephalomyelitis by potentiating Th17 differentiation

(2012) Hideyuki Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Protein Kinase C-  Promotes Th17 Differentiation via Upregulation of Stat3

(2012) M.-J. Kwon et al.   JOURNAL OF IMMUNOLOGY

Protein Kinase C-  Inhibits Inducible Regulatory T Cell Differentiation via an AKT-Foxo1/3a-Dependent Pathway

(2012) J. Ma et al.   JOURNAL OF IMMUNOLOGY

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species

(2012) Vincenzo Giambra et al.   NATURE MEDICINE

PKC Theta Ablation Improves Healing in a Mouse Model of Muscular Dystrophy

(2012) Luca Madaro et al.   PLoS One

Protein Kinase C-θ (PKC-θ) in Natural Killer Cell Function and Anti-Tumor Immunity

(2012) Alberto Anel et al.   Frontiers in Immunology

PKC-theta-mediated signal delivery from the TCR/CD28 surface receptors

(2012) Noah Isakov et al.   Frontiers in Immunology

Protein Kinase C-Theta Is Required for Development of Experimental Cerebral Malaria

(2011) Mathilde Fauconnier et al.   AMERICAN JOURNAL OF PATHOLOGY

A motif in the V3 domain of the kinase PKC-θ determines its localization in the immunological synapse and functions in T cells via association with CD28

(2011) Kok-Fai Kong et al.   NATURE IMMUNOLOGY

Low-strength T-cell activation promotes Th17 responses

(2010) H. A. Purvis et al.   BLOOD

Genetic proof for the transient nature of the Th17 phenotype

(2010) Florian C. Kurschus et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Protective Toxoplasma gondii-Specific T-Cell Responses Require T-Cell-Specific Expression of Protein Kinase C-Theta

(2010) G. Nishanth et al.   INFECTION AND IMMUNITY

Protein Kinase C-  Mediates Negative Feedback on Regulatory T Cell Function

(2010) A. Zanin-Zhorov et al.   SCIENCE

Protein kinase C: poised to signal

(2009) Alexandra C. Newton   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PKC inhibitors: potential in T cell-dependent immune diseases

(2009) Gottfried Baier et al.   CURRENT OPINION IN CELL BIOLOGY

Th17 cells promote pancreatic inflammation but only induce diabetes efficiently in lymphopenic hosts after conversion into Th1 cells

(2009) Natalia Martin-Orozco et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cross-regulation of Signaling Pathways by Interferon-γ: Implications for Immune Responses and Autoimmune Diseases

(2009) Xiaoyu Hu et al.   IMMUNITY

PKCθ is required for alloreactivity and GVHD but not for immune responses toward leukemia and infection in mice

(2009) Javier O. Valenzuela et al.   JOURNAL OF CLINICAL INVESTIGATION

PKCθ cooperates with PKCα in alloimmune responses of T cells in vivo

(2009) Thomas Gruber et al.   MOLECULAR IMMUNOLOGY

PKC-  Modulates the Strength of T Cell Responses by Targeting Cbl-b for Ubiquitination and Degradation

(2009) T. Gruber et al.   Science Signaling

The Nuclear Orphan Receptor NR2F6 Suppresses Lymphocyte Activation and T Helper 17-Dependent Autoimmunity

(2008) Natascha Hermann-Kleiter et al.   IMMUNITY

Impaired anti-leukemic immune response in PKCθ-deficient mice

(2008) Johan Garaude et al.   MOLECULAR IMMUNOLOGY

Differential requirement of PKC-θ in the development and function of natural regulatory T cells

(2008) Sonal Gupta et al.   MOLECULAR IMMUNOLOGY

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

(2008) Ingunn M Stromnes et al.   NATURE MEDICINE

Differential Invasion ofTrypanosoma brucei bruceiand Lymphocytes into the Brain of C57BL/6 and 129Sv/Ev Mice

(2008) W. Masocha et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

T-cell fate and function: PKC-θ and beyond

(2008) Benjamin J. Marsland et al.   TRENDS IN IMMUNOLOGY

Protein Kinase C θ Plays a Fundamental Role in Different Types of Chronic Colitis

(2007) Kiyotaka Nagahama et al.   GASTROENTEROLOGY