期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 42, 期 -, 页码 1168-1173出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20140066
关键词
AS-NMD; development; physiological response; post-transcriptional regulation of gene expression; RNA metabolism
资金
- National Medical Research Council [NMRC/CBRG/0028/2013]
- Nanyang President Graduate Scholarship
Higher eukaryotes rely on AS (alternative splicing) of pre-mRNAs (mRNA precursors) to generate more than one protein product from a single gene and to regulate mRNA stability and translational activity. An important example of the latter function involves an interplay between AS and NMD (nonsense-mediated decay), a cytoplasmic quality control mechanism eliminating mRNAs containing PTCs (premature translation termination codons). Although originally identified as an error surveillance process, AS-NMD additionally provides an efficient strategy for deterministic regulation of gene expression outputs. In this review, we discuss recently published examples of AS-NMD and delineate functional contexts where recurrent use of this mechanism orchestrates expression of important genes.
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