期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 41, 期 -, 页码 923-926出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20130036
关键词
eukaryotic elongation factor 2 (eEF2); mammalian target of rapamycin complex 1 (mTORC1); mRNA translation; ribosome biogenesis; rRNA; translation initiation
资金
- Biotechnology and Biological Sciences Research Council
- British Heart Foundation
- Cancer Research UK
- Royal Society
- Wellcome Trust
mTORC1 (mammalian target of rapamycin complex 1) is activated by nutrients, growth factors and certain hormones. Signalling downstream of mTORC1 promotes protein synthesis by both activating the processes of translation initiation and elongation, in the short term, and the production of new ribosomes, in the longer term. mTORC1 signalling stimulates the translation of the mRNAs encoding the ribosomal proteins, activates RNA polymerases I and Ill, which make the rRNAs, and promotes the processing of the precursor for the main rRNAs. Taken together, these effects allow mTORC1 signalling to drive cell growth and proliferation.
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