期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 41, 期 -, 页码 50-55出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20120210
关键词
budding; haemagglutinin (HA); influenza virus; M2; membrane fusion; virus taxonomy
资金
- German Research Foundation [Ve 141/10]
- Russian Foundation for Basic Research [10 04 91333, 12 04 01695]
- DFG (Priority Programme 1175, Collaborative Research Centre 740)
- European Commission (Marie Curie Initial Training Network 'Virus-Entry')
Influenza viruses contain two palmitoylated (S-acylated) proteins: the major spike protein HA (haemagglutinin) and the proton-channel M2. The present review describes the fundamental biochemistry of palmitoylation of HA: the location of palmitoylation sites and the fatty acid species bound to HA. Finally, the functional consequences of palmitoylation of HA and M2 are discussed regarding association with membrane rafts, entry of viruses into target cells by HA-mediated membrane fusion as well as the release of newly assembled virus particles from infected cells.
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