期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 41, 期 -, 页码 95-100出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20120269
关键词
FXYD; heart; ion transport; Na+ pump; palmitoylation; phospholemman
资金
- British Heart Foundation [RG/07/001]
- MRC [G0001230, G0700903] Funding Source: UKRI
- British Heart Foundation [PG/12/6/29366, RG/12/4/29426] Funding Source: researchfish
- Medical Research Council [G0001230, G0700903] Funding Source: researchfish
The Na+/K+-ATPase (Na+ pump) is the principal consumer of ATP in multicellular organisms. In the heart, the Na+ gradient established by the pump is essential for all aspects of cardiac function, and appropriate regulation of the cardiac Na+ pump is therefore crucial to match cardiac output to the physiological requirements of an organism. The cardiac pump is a multi-subunit enzyme, consisting of a catalytic alpha-subunit and regulatory beta- and FXYD subunits. All three subunits may become palmitoylated, although the functional outcome of these palmitoylation events is incompletely characterized to date. Interestingly, both beta- and FXYD subunits may be palmitoylated or glutathionylated at the same cysteine residues. These competing chemically distinct post-translational modifications may mediate functionally different effects on the cardiac pump. In the present article, we review the cellular events that control the balance between these modifications, and discuss the likely functional effects of pump subunit palmitoylation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据