期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 40, 期 -, 页码 1353-1359出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20120167
关键词
adenylylation; Coxiella burnetii; intracellular trafficking; Legionella pneumophila; phosphocholination; Rab GTPase
资金
- American Society for Microbiology Robert D. Watkins Graduate Research Fellowship
- National Institutes of Health Ruth L. Kirschstein National Research Service Award Individual Postdoctoral Fellowship
- National Health and Medical Research Council Training Fellowship
- National Institutes of Health [R01-AI064559]
- Northeast Biodefense Center [U54-AI057158-Lipkin]
Intracellular pathogens survive in eukaryotic cells by evading a variety of host defences. To avoid degradation through the endocytic pathway, intracellular bacteria must adapt their phagosomes into protective compartments that promote bacterial replication. Legionella pneumophila and Coxiella burnetii are Gram-negative intracellular pathogens that remodel their phagosomes by co-opting components of the host cell, including Rab GTPases. L. pneumophila and C. burnetii are related phylogenetically and share an analogous type IV secretion system for delivering bacterial effectors into the host cell. Some of these effectors mimic eukaryotic biochemical activities to recruit and modify Rabs at the vacuole. In the present review, we cover how these bacterial species, which utilize divergent strategies to establish replicative vacuoles, use translocated proteins to manipulate host Rabs, as well as exploring which Rabs are implicated in vacuolar biogenesis in these two organisms.
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