标题
LRRK2 GTPase dysfunction in the pathogenesis of Parkinson's disease
作者
关键词
-
出版物
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 40, Issue 5, Pages 1074-1079
出版商
Portland Press Ltd.
发表日期
2012-11-09
DOI
10.1042/bst20120093
参考文献
相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。- Is inhibition of kinase activity the only therapeutic strategy for LRRK2-associated Parkinson's disease?
- (2012) Iakov N Rudenko et al. BMC Medicine
- ArfGAP1 Is a GTPase Activating Protein for LRRK2: Reciprocal Regulation of ArfGAP1 by LRRK2
- (2012) Y. Xiong et al. JOURNAL OF NEUROSCIENCE
- Leucine-rich repeat kinase 2 (LRRK2) as a potential therapeutic target in Parkinson's disease
- (2012) Byoung Dae Lee et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- A Mutation in VPS35, Encoding a Subunit of the Retromer Complex, Causes Late-Onset Parkinson Disease
- (2011) Alexander Zimprich et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Translation Initiator EIF4G1 Mutations in Familial Parkinson Disease
- (2011) Marie-Christine Chartier-Harlin et al. AMERICAN JOURNAL OF HUMAN GENETICS
- VPS35 Mutations in Parkinson Disease
- (2011) Carles Vilariño-Güell et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Recent Advances in the Genetics of Parkinson's Disease
- (2011) Ian Martin et al. Annual Review of Genomics and Human Genetics
- Re-examination of the dimerization state of leucine-rich repeat kinase 2: predominance of the monomeric form
- (2011) Genta Ito et al. BIOCHEMICAL JOURNAL
- Kinetic, Mechanistic, and Structural Modeling Studies of Truncated Wild-Type Leucine-Rich Repeat Kinase 2 and the G2019S Mutant
- (2011) Min Liu et al. BIOCHEMISTRY
- LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice
- (2011) Martin C. Herzig et al. HUMAN MOLECULAR GENETICS
- Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning
- (2011) M. W. Dodson et al. HUMAN MOLECULAR GENETICS
- Inhibitors of LRRK2 kinase attenuate neurodegeneration and Parkinson-like phenotypes in Caenorhabditis elegans and Drosophila Parkinson's disease models
- (2011) Zhaohui Liu et al. HUMAN MOLECULAR GENETICS
- Comprehensive mutational analysis of LRRK2 reveals variants supporting association with autosomal dominant Parkinson's disease
- (2011) Naomi Seki et al. JOURNAL OF HUMAN GENETICS
- Autophosphorylation in the Leucine-Rich Repeat Kinase 2 (LRRK2) GTPase Domain Modifies Kinase and GTP-Binding Activities
- (2011) Philip J. Webber et al. JOURNAL OF MOLECULAR BIOLOGY
- The kinase LRRK2 is a regulator of the transcription factor NFAT that modulates the severity of inflammatory bowel disease
- (2011) Zhihua Liu et al. NATURE IMMUNOLOGY
- LRRK2 Kinase Activity Is Dependent on LRRK2 GTP Binding Capacity but Independent of LRRK2 GTP Binding
- (2011) Jean-Marc Taymans et al. PLoS One
- LRRK2 signaling pathways: the key to unlocking neurodegeneration?
- (2011) Daniel C. Berwick et al. TRENDS IN CELL BIOLOGY
- Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant
- (2010) Veronique Daniëls et al. JOURNAL OF NEUROCHEMISTRY
- Phosphopeptide Analysis Reveals Two Discrete Clusters of Phosphorylation in the N-Terminus and the Roc Domain of the Parkinson-Disease Associated Protein Kinase LRRK2
- (2010) Christian Johannes Gloeckner et al. JOURNAL OF PROTEOME RESEARCH
- Novel pathogenic LRRK2 p.Asn1437His substitution in familial Parkinson's disease
- (2010) Jan O. Aasly et al. MOVEMENT DISORDERS
- Inhibitors of leucine-rich repeat kinase-2 protect against models of Parkinson's disease
- (2010) Byoung Dae Lee et al. NATURE MEDICINE
- The role of leucine-rich repeat kinase 2 (LRRK2) in Parkinson's disease
- (2010) Mark R. Cookson NATURE REVIEWS NEUROSCIENCE
- ARHGEF7 (BETA-PIX) Acts as Guanine Nucleotide Exchange Factor for Leucine-Rich Repeat Kinase 2
- (2010) Karina Haebig et al. PLoS One
- Loss of leucine-rich repeat kinase 2 causes impairment of protein degradation pathways, accumulation of -synuclein, and apoptotic cell death in aged mice
- (2010) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- GTPase Activity Plays a Key Role in the Pathobiology of LRRK2
- (2010) Yulan Xiong et al. PLoS Genetics
- The Parkinson’s disease kinase LRRK2 autophosphorylates its GTPase domain at multiple sites
- (2009) Elisa Greggio et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification of the Autophosphorylation Sites of LRRK2
- (2009) Shogo Kamikawaji et al. BIOCHEMISTRY
- LRRK2 in Parkinson’s disease: genetic and clinical studies from patients
- (2009) Udhaya Kumari et al. FEBS Journal
- LRRK2 regulates autophagic activity and localizes to specific membrane microdomains in a novel human genomic reporter cellular model
- (2009) Javier Alegre-Abarrategui et al. HUMAN MOLECULAR GENETICS
- Dependence of Leucine-rich Repeat Kinase 2 (LRRK2) Kinase Activity on Dimerization
- (2009) Saurabh Sen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Parkinson's disease
- (2009) Andrew J Lees et al. LANCET
- Mutant LRRK2 R1441G BAC transgenic mice recapitulate cardinal features of Parkinson's disease
- (2009) Yanping Li et al. NATURE NEUROSCIENCE
- It takes two to tango: regulation of G proteins by dimerization
- (2009) Raphael Gasper et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- R1441C mutation in LRRK2 impairs dopaminergic neurotransmission in mice
- (2009) Y. Tong et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Zeroing in on LRRK2-linked pathogenic mechanisms in Parkinson's disease
- (2008) Saskia Biskup et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- Haplotype analysis of Lrrk2 R1441H carriers with parkinsonism
- (2008) Owen A. Ross et al. PARKINSONISM & RELATED DISORDERS
- Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase
- (2008) J. Deng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ROCO Kinase Activity Is Controlled by Internal GTPase Function
- (2008) B. Weiss Science Signaling
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation