Structural, mechanistic and regulatory studies of serine palmitoyltransferase

Lipid classification, structures and tools

(2011) Eoin Fahy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Sphingolipid and Glycosphingolipid Metabolic Pathways in the Era of Sphingolipidomics

(2011) Alfred H. Merrill   CHEMICAL REVIEWS

Role of a conserved arginine residue during catalysis in serine palmitoyltransferase

(2011) Jonathan Lowther et al.   FEBS LETTERS

Two Pathways of Sphingolipid Biosynthesis Are Separated in the YeastPichia pastoris

(2011) Philipp Ternes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Oral l-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1

(2011) Kevin Garofalo et al.   JOURNAL OF CLINICAL INVESTIGATION

Discovery of deoxyceramides and diacylglycerols as CD1b scaffold lipids among diverse groove-blocking lipids of the human CD1 system

(2011) S. Huang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein kinase Ypk1 phosphorylates regulatory proteins Orm1 and Orm2 to control sphingolipid homeostasis in Saccharomyces cerevisiae

(2011) F. M. Roelants et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism

(2011) Florence Bourquin et al.   PROTEIN SCIENCE

Mutations in the SPTLC2 Subunit of Serine Palmitoyltransferase Cause Hereditary Sensory and Autonomic Neuropathy Type I

(2010) Annelies Rotthier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The serine palmitoyltransferase from Sphingomonas wittichii RW1: An interesting link to an unusual acyl carrier protein

(2010) Marine C. C. Raman et al.   BIOPOLYMERS

A Disease-causing Mutation in the Active Site of Serine Palmitoyltransferase Causes Catalytic Promiscuity

(2010) Kenneth Gable et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hereditary Sensory Neuropathy Type 1 Is Caused by the Accumulation of Two Neurotoxic Sphingolipids

(2010) Anke Penno et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A novel selective growth medium-PCR assay to isolate and detect Sphingomonas in environmental samples

(2010) Mi-Sung Yim et al.   JOURNAL OF MICROBIOLOGICAL METHODS

Inhibition of the PLP-dependent enzyme serine palmitoyltransferase by cycloserine: evidence for a novel decarboxylative mechanism of inactivation

(2010) Jonathan Lowther et al.   Molecular BioSystems

Orm family proteins mediate sphingolipid homeostasis

(2010) David K. Breslow et al.   NATURE

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane sphingolipids as essential molecular signals for Bacteroides survival in the intestine

(2010) D. An et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Insights into the Enzymatic Mechanism of Serine Palmitoyltransferase from Sphingobacterium multivorum

(2009) H. Ikushiro et al.   JOURNAL OF BIOCHEMISTRY

The External Aldimine Form of Serine Palmitoyltransferase

(2009) Marine C. C. Raman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Multifunctional Role of His159in the Catalytic Reaction of Serine Palmitoyltransferase

(2009) Yuka Shiraiwa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Insights into the Biosynthesis of the Vibrio cholerae Major Autoinducer CAI-1 from the Crystal Structure of the PLP-Dependent Enzyme CqsA

(2009) Nasrin Jahan et al.   JOURNAL OF MOLECULAR BIOLOGY

The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA

(2009) Robert C Kelly et al.   Nature Chemical Biology

Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities

(2009) G. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amino acid-containing membrane lipids in bacteria

(2009) Otto Geiger et al.   PROGRESS IN LIPID RESEARCH

Ceramide Synthase Inhibition by Fumonisin B1Causes Accumulation of 1-Deoxysphinganine

(2008) Nicholas C. Zitomer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss-of-function mutations and inducible RNAi suppression of Arabidopsis LCB2 genes reveal the critical role of sphingolipids in gametophytic and sporophytic cell viability

(2008) Charles R. Dietrich et al.   PLANT JOURNAL