期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 40, 期 -, 页码 759-761出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST20120023
关键词
co-transcriptional processing; Drosha; intronic microRNA (intronic miRNA); splicing
资金
- Royal Society University Research Fellowship
- Ataxia UK [7126] Funding Source: researchfish
- Medical Research Council [MR/J007870/1] Funding Source: researchfish
- Motor Neurone Disease Association [Gromak/Jun11/6278] Funding Source: researchfish
Most human genes transcribed by RNA Pol II (polymerase II) contain short exons separated by long tracts of non-coding intronic sequences. In addition to their role in generating proteomic diversity through the process of alternative splicing, intronic sequences host many ncRNAs (non-coding RNAs), involved in various gene regulation processes. miRNAs (microRNAs) are short ncRNAs that mediate either mRNA transcript translational repression and/or degradation. Between 50 and 80 % of miRNAs are encoded within introns of host mRNA genes. This observation suggests that there is co-regulation between the miRNA biogenesis and pre-mRNA splicing processes. The present review summarizes current advances in this field and discusses possible roles for intronic co-transcriptional cleavage events in the regulation of human gene expression.
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