Review
Pharmacology & Pharmacy
Paul T. Winnard, Farhad Vesuna, Venu Raman
Summary: DDX3X, a multifunctional protein utilized by various viruses, plays a crucial role in viral metabolism. Modulating the functions of DDX3 during viral infections could effectively suppress viral production and have a significant impact on safely and efficiently subduing a broad spectrum of viral infections.
ANTIVIRAL RESEARCH
(2021)
Review
Microbiology
Chonghui Xu, Jizheng Chen, Xinwen Chen
Summary: Hepatitis viruses are the primary causative agents of hepatitis and pose a major public health issue globally. The host innate immune system acts as the first line of defense against these viruses. However, hepatitis viruses evade host immune surveillance through various strategies, compromising the innate immune response and creating a favorable environment for viral replication.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Virology
Rizwan Ullah, Jia Li, Puxian Fang, Shaobo Xiao, Liurong Fang
Summary: DEAD/H-box RNA helicases are important members of the super family-2 helicases, participating in almost all RNA-related processes and playing crucial roles in anti-viral immunity. Some helicases act as viral nucleic acid sensors or co-sensors, triggering immune responses. However, other helicases can be exploited by viruses to evade immune responses while serving as viral replication cofactors.
Article
Biochemistry & Molecular Biology
Mohammad Sadic, William M. Schneider, Olga Katsara, Gisselle N. Medina, Ashley Fisher, Aishwarya Mogulothu, Yingpu Yu, Meigang Gu, Teresa de Los Santos, Robert J. Schneider, Meike Dittmann
Summary: DDX60, an interferon-stimulated helicase, selectively reduces translation from certain viral IRESs to inhibit viral replication.
Article
Biochemistry & Molecular Biology
Sarah Venus, Kaba Tandjigora, Eckhard Jankowsky
Summary: The protein K7 from vaccinia virus is shown to inhibit the biochemical activities and cellular functions of DDX3X by binding to its N-terminus, restraining its association with stress granules.
JOURNAL OF MOLECULAR BIOLOGY
(2023)
Review
Immunology
Yihan Liu, Yupei Yuan, Leiliang Zhang
Summary: This article focuses on the mechanisms employed by alphaviruses to evade host immune responses, which is crucial for understanding the pathogenesis of alphaviruses and developing effective strategies for infection control.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Fisheries
Jian Xu, Yunhong Cai, Zhenbang Ma, Bo Jiang, Wenxiao Liu, Jing Cheng, Huan Jin, Yongqing Li
Summary: This study found that MDV inhibits the production of IFN-beta by regulating DDX5, thereby promoting viral replication. DDX5 plays a role in MDV replication by regulating the interferon signaling pathway and other mechanisms.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2021)
Review
Immunology
Zhijie Jian, Rui Ma, Ling Zhu, Huidan Deng, Fengqin Li, Jun Zhao, Lishuang Deng, Siyuan Lai, Xiangang Sun, Huaqiao Tang, Zhiwen Xu
Summary: This article reviews the strategies used by Arteriviruses to antagonize IFN production and thwart IFN-activated antiviral signaling, emphasizing the significance of this research in understanding the pathogenesis of arthritis virus and developing vaccines.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
David P. Maison, Youping Deng, Mariana Gerschenson
Summary: The SARS-CoV-2 pandemic and COVID-19 disease have had a global impact, sparking a significant surge in research. To evaluate future approaches, understanding the host immune response and viral antagonism is crucial. This review summarizes current knowledge on SARS-CoV-2, focusing on the viral genome, replication cycle, host immune activation, response, signaling, and antagonism. Efforts should be directed towards current research to develop treatments and prepare for future outbreaks.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Virology
Cindy Chiang, Guanqun Liu, Michaela U. Gack
Summary: Viral manipulation of ubiquitin or ISG15-mediated immune responses is a key strategy for virus evasion, including direct targeting of ubiquitin E3 ligases, active deubiquitination using viral DUBs, and the upregulation of cellular DUBs to regulate RLR signaling. Certain coronaviruses, such as SARS-CoV-2, actively deISGylate key molecules in the RLR pathway to escape type I interferon-mediated antiviral responses. Targeting virally-encoded proteins that manipulate ubiquitin or ISG15-mediated innate immune responses may be a potential strategy for the development of new antivirals and vaccines.
Review
Virology
Lucia Amurri, Olivier Reynard, Denis Gerlier, Branka Horvat, Mathieu Iampietro
Summary: The immune system deploys a complex network of cells and signaling pathways to protect the host against exogenous threats, including the measles virus. Despite the availability of a vaccine, the measles virus has been re-emerging and its prevalence has been increasing worldwide. Recent studies have revealed a novel aspect of the innate immune response against the measles virus, involving DNA-related sensing.
Review
Immunology
Michelle Felicia Lee, Guan Zhong Voon, Hui Xuan Lim, Mun Lok Chua, Chit Laa Poh
Summary: Dengue is a mosquito-borne disease that poses significant public health concerns in tropical and subtropical countries. The dengue virus has evolved various strategies to manipulate the host's immune responses, and miRNAs and DENV non-structural proteins (NS) are promising targets for anti-dengue therapeutics.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Review
Immunology
Shubo Wen, Xintong Li, Xiangyu Lv, Kai Liu, Jingqiang Ren, Jingbo Zhai, Yang Song
Summary: Interferon (IFN) is a crucial antiviral cytokine involved in host defense against virus invasion. Pathogens have developed strategies to escape the IFN-mediated immune response. This review focuses on the mechanisms mediated by Npro of pestiviruses to counteract IFN production.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Xiao Wang, Yupei Yuan, Yihan Liu, Leiliang Zhang
Summary: This article provides an overview of the pathogenesis of Rift Valley fever (RVF) and the immune evasion competition between the virus and the host. Understanding the host immune response and viral antibodies can help identify new drug targets and potential solutions for current and future epidemics.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Takahisa Kouwaki, Tasuku Nishimura, Guanming Wang, Hiroyuki Oshiumi
Summary: RIG-I-like receptors (RLR), including RIG-I and MDA5, are crucial for the innate immune response to SARS-CoV-2, with both proteins involved in regulating cytokine expression. Transfection of viral RNA regions and viral proteins have effects on the immune response generation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Simone Z. Vogel, Stephan Schlickeiser, Karsten Juerchott, Levent Akyuez, Julia Schumann, Christine Appelt, Katrin Vogt, Martina Schroeder, Martin Vaeth, Friederike Berberich-Siebelt, Manfred B. Lutz, Gerald Gruetz, Birgit Sawitzki
JOURNAL OF IMMUNOLOGY
(2015)
Article
Biochemistry & Molecular Biology
Lili Gu, Anthony Fullam, Niamh McCormack, Yvette Hohn, Martina Schroeder
BIOCHEMICAL JOURNAL
(2017)
Article
Pharmacology & Pharmacy
Martina Schroeder
BIOCHEMICAL PHARMACOLOGY
(2010)
Review
Biochemistry & Molecular Biology
Anthony Fullam, Martina Schroeder
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2013)
Article
Cell Biology
Ruth Brennan, Antje Haap-Hoff, Lili Gu, Virginie Gautier, Aideen Long, Martina Schroder
EUROPEAN JOURNAL OF CELL BIOLOGY
(2018)
Article
Immunology
Daniela Bruni, Jordi Sebastia, Susan Dunne, Martina Schroeder, Marion P. Butler
JOURNAL OF IMMUNOLOGY
(2013)
Article
Cell Biology
Aideen S. Collins, Suaad Ahmed, Silvia Napoletano, Martina Schroeder, James A. Johnston, John E. Hegarty, Cliona O'Farrelly, Nigel J. Stevenson
JOURNAL OF LEUKOCYTE BIOLOGY
(2014)
Article
Biochemistry & Molecular Biology
Lili Gu, Anthony Fullam, Ruth Brennan, Martina Schroeder
MOLECULAR AND CELLULAR BIOLOGY
(2013)
Article
Biochemistry & Molecular Biology
Anthony Fullam, Lili Gu, Yvette Hoehn, Martina Schroeder
BIOCHEMICAL JOURNAL
(2018)
Article
Chemistry, Multidisciplinary
Lokesh K. Kumawat, Anthony A. Abogunrin, Michelle Kickham, Jyotsna Pardeshi, Oda Fenelon, Martina Schroeder, Robert B. P. Elmes
FRONTIERS IN CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Orla Convery, Siobhan Gargan, Michelle Kickham, Martina Schroder, Cliona O'Farrelly, Nigel J. Stevenson
Article
Immunology
Ioannis Kienes, Sarah Bauer, Clarissa Gottschild, Nora Mirza, Jens Pfannstiel, Martina Schroeder, Thomas A. Kufer
Summary: The study reveals that NLRP11 plays a role in regulating type I IFN induction during viral infection and controls NLRP3 inflammasome activation by binding to DDX3X. NLRP11 abolishes IKK epsilon-mediated phosphorylation of DDX3X, leading to reduced type I IFN induction upon viral infection. By interacting with DDX3X through the LRR domain, NLRP11 suppresses NLRP3-mediated inflammasome activation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jyotsna Pardeshi, Niamh McCormack, Lili Gu, Cathal S. Ryan, Martina Schroder
Summary: This study reveals a novel physical interaction between DDX3X and ERα, which positively regulates ERα activation. Knockdown of DDX3X reduces ERα phosphorylation, expression of target genes, and cell proliferation, while overexpression of DDX3X enhances ERα phosphorylation and activity. These findings suggest an important role of DDX3X in breast cancer development and resistance to endocrine therapy.
BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS
(2022)
Review
Cell Biology
Cathal S. Ryan, Martina Schroeder
Summary: The human DEAD-box protein DDX3X plays a crucial role in RNA metabolism and has been associated with various diseases, including cancer and neurodevelopmental conditions. It also plays a significant role in viral infections. DDX3X is involved in translation initiation and stress response, and understanding its regulatory mechanisms is important for developing therapeutic strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
