期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 1639-1644出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0381639
关键词
anaphase; anaphase promoting complex; cohesin; cyclin dependent kinase
资金
- Fundacao para a Ciencia e Tecnologia of Portugal [SFRH/BPD/38013/2007]
- Medical Research Council (MRC)
- Welcome Trust
- Fundação para a Ciência e a Tecnologia [SFRH/BPD/38013/2007] Funding Source: FCT
Sister chromatid cohesion thought to be primarily mediated by the cohesin complex is essential for chromosome segregation The forces holding the two sisters resist the tendency of microtubules to prematurely pull sister DNAs apart and thereby prevent random segregation of the genome during mitosis and consequent aneuploidy By counteracting the spindle pulling forces cohesion between the two sisters generates the tension necessary to stabilize microtubule-kinetochore attachments Upon entry into anaphase however the linkages that hold the two sister (DNAs must be rapidly destroyed to allow physical separation of chromatids Anaphase cells must therefore possess mechanisms that ensure faithful segregation of single chromatids that are now attached stably to the spindle in a manner no longer dependent on tension In the present review we discuss the nature of the cohesive forces that hold sister chromatid together the mechanisms that trigger their physical separation and the anaphase specific changes that ensure proper segregation of single chromatids during the later stages of mitosis
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据