期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 1517-1522出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0381517
关键词
DAZ microRNA (miRNA); mRNA specific translational control; poly(A) binding protein (PABP); sex lethal Y box 1 (YB 1)
资金
- Medical Research Council (MRC)
- MRC
- Wellcome Trust
- MRC [MC_U127561111, MC_U127692697, G117/564] Funding Source: UKRI
- Medical Research Council [G117/564, MC_U127692697, MC_U127561111] Funding Source: researchfish
The regulation of translation has emerged as a major determinant of gene expression and is critical for both normal cellular function and the development of disease Numerous studies have highlighted the diverse and sometimes related mechanisms which underlie the regulation of global translation rates and the translational control of specific mRNAs In the present paper we discuss the emerging roles of the basal translation factor PABP [poly(A) binding protein] in mRNA specific translational control in metazoa which suggest that PABP function is more complex than first recognized
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