期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 1122-1124出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0381122
关键词
alternative polyadenylation; alternative splicing; embryonic lethal abnormal visual system (ELAV); nervous system development
资金
- Biotechnology and Biological Sciences Research Council
- Biotechnology and Biological Sciences Research Council [BB/F000855/1] Funding Source: researchfish
- BBSRC [BB/F000855/1] Funding Source: UKRI
How RNA-binding proteins recognize their complement of targets in a complex cellular environment remains poorly understood. Sequence degeneracy and redundancy of short motifs at genomic scales have mostly eluded predictions of specific target genes for gene-specific ELAV (embryonic lethal abnormal visual system)/Hu proteins that bind ubiquitous AU-rich motifs. Using the genetic tools of Drosophila, we have analysed binding properties of ELAV in vitro and ELAV-dependent regulation of its major target ewg (erect wing) in neurons. These studies reveal that an integral part of ELAV gene-specific regulation involves combinatorial binding to variably spaced short U-rich motifs on an extensive binding site.
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