期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 38, 期 -, 页码 1698-1703出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0381698
关键词
aneuploidy; breakage; fusion-bridge cycle; carcinogenesis; chromosome instability; telomere
资金
- Consejo de Seguridad Nuclear Instituto de Salud Carlos III [RD06/0020/1020]
- Generalitat de Catalunya [2009SGR 282]
Chromosomal instability occurs early in the development of cancer and may represent an important step in promoting the multiple genetic changes required for the initiation and/or progression of the disease Telomere erosion is one of the factors that contribute to chromosome instability through end to end chromosome fusions entering BFB (breakage-fusion-bridge) cycles Uncapped chromosomes with short dysfunctional telomeres represent an initiating substrate for both pre and post replicative joining which leads to unstable chromosome rearrangements prone to bridge at mitotic anaphase Resolution of chromatin bridge intermediates is likely to contribute greatly to the generation of segmental chromosome amplification events unbalanced chromosome rearrangements and whole chromosome aneuploidy Accordingly telomere driven instability generates highly unstable genomes that could promote cell immortalization and the acquisition of a tumour phenotype
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