期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 37, 期 -, 页码 768-771出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0370768
关键词
co-evolution; duplication; protein interaction network; protein-protein interaction; rewiring
资金
- Biotechnology and Biological Sciences Research Council [BB/F007620/1, BB/F013337/1, BB/C515412/1] Funding Source: researchfish
- BBSRC [BB/F007620/1, BB/F013337/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/F013337/1, BB/F007620/1, BB/C515412/1] Funding Source: Medline
Molecular function is the result of proteins working together, mediated by highly specific interactions. Maintenance and change of protein interactions can thus be considered one of the main links between molecular function and mutation. As a consequence, protein interaction datasets can be used to study functional evolution directly. In terms of constraining change, the co-evolution of interacting molecules is a very subtle process. This has implications for the signal being used to predict protein-protein interactions. In terms of functional change, the 'rewiring' of interaction networks, gene duplication is critically important. interestingly, once duplication has occurred, the genes involved have different probabilities of being retained related to how they were generated. In the present paper, we discuss some of our recent work in this area.
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