期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 37, 期 -, 页码 1399-1403出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0371399
关键词
adenosine deaminase that acts on RNA (ADAR); central nervous System (CNS); endoplasmic reticulum; gamma-aminobutyric acid type A receptor (GABA(A) receptor); RNA editing; transmembrane region
资金
- Swedish Research Council [NT2006-5415]
A-to-I (adenosine-to-inosine) RNA editing catalysed by the ADARs (adenosine deaminases that act on RNA) is a post-transcriptional event that contributes to protein diversity in metazoans. in mammalian neuronal ion channels, editing alters functionally important amino acids and creates receptor subtypes important for the development of the nervous system. The excitatory AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid) and kainate glutamate receptors, as well as the inhibitory GABA(A) [GABA (gamma-aminobutyric acid) type A] receptor, are subject to A-to-I RNA editing. Editing affects several features of the receptors, including kinetics, subunit assembly and cell-surface expression. Here, we discuss the regulation of editing during brain maturation and the impact of RNA editing on the expression of different receptor subtypes.
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