期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 36, 期 -, 页码 1224-1231出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0361224
关键词
gene expression; in vitro-transcribed RNA; microRNA (miRNA); polysomes; protein synthesis; translation
资金
- BBSRC (Biotechnology and Biological Science Research Council)
- Biotechnology and Biological Sciences Research Council [BB/C514766/1] Funding Source: researchfish
miRNAs (microRNAs) are short non-coding RNAs that regulate gene expression post-transcriptionally. They generally bind to the 3'-UTR (untranslated region) of their target mRNAs and repress protein production by destabilizing the mRNA and translational silencing. The exact mechanism of miRNA-mediated translational repression is yet to be fully determined, but recent data from our laboratory have shown that the stage of translation which is inhibited by miRNAs is dependent upon the promoter used for transcribing the target mRNA. This review focuses on understanding how miRNA repression is operating in light of these findings and the questions that still remain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据