期刊
JOURNAL OF BIOLOGICAL CHEMISTRY
卷 290, 期 48, 页码 28675-28682出版社
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M115.661611
关键词
ADP-ribosylation; forkhead box P3 (FOXP3); immunosuppression; inhibitor; posttranscriptional regulation; T cell; regulatory T cell
资金
- Chinese National Program on Key Basic Research Project [2014CB541800, 2014CB541900]
- NSFC [81330072, 31300711, 31370863, 31170825, 31200646, 31200647]
- Shanghai Key Grant [14JC1406100]
- Shanghai Three-year Plan on Promoting TCM Development Grant [ZY3-LCPT-2-1003]
Poly(ADP-ribose) polymerase 1 (PARP-1) is an ADP-ribosylating enzyme participating in diverse cellular functions. The roles of PARP-1 in the immune system, however, have not been well understood. Here we find that PARP-1 interacts with FOXP3 and induces its poly(ADP-ribosyl)ation. By using PARP-1 inhibitors, we show that reduced poly(ADP-ribosyl)ation of FOXP3 results in not only FOXP3 stabilization and increased FOXP3 downstream genes but also enhanced suppressive function of regulatory T cells. Our results suggest that PARP-1 negatively regulates the suppressive function of Treg cells at the posttranslational level via FOXP3 poly(ADP-ribosyl)ation. This finding has implications for developing PARP-1 inhibitors as potential agents for the prevention and treatment of autoimmune diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据