Article
Immunology
Jing Zhao, Hyuneui Jeong, Daram Yang, Weishun Tian, Jong-Won Kim, Chae Woong Lim, Bumseok Kim
Summary: TLR7 plays a critical role in ConA-induced liver injury, and its deficiency attenuates liver damage and reduces the release of hepatic pro-inflammatory cytokines. TLR7 deficiency also inhibits the proliferation of CD4+ T cells stimulated by ConA and specifically suppresses the expression of TNF-alpha in liver Kupffer cells. Depletion of Kupffer cells abolishes the detrimental role of TLR7 in ConA-induced liver injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell & Tissue Engineering
Yulin He, Xingrong Guo, Tingyu Lan, Jianbo Xia, Jinsong Wang, Bei Li, Chunyan Peng, Yue Chen, Xiang Hu, Zhongji Meng
Summary: The transplantation of hUC-MSCs can improve liver function, degree of fibrosis, and liver damage in rats with ACLI or ACLF, likely mediated by inhibiting Notch signaling and reversing the imbalance of the Stat1/Stat3 pathway.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Pharmacology & Pharmacy
Zihao Fan, Yuxian Li, Sisi Chen, Ling Xu, Yuan Tian, Yaling Cao, Zhenzhen Pan, Xiangying Zhang, Yu Chen, Feng Ren
Summary: The novel glycyrrhizin MgIG extracted from licorice has shown a significant protective effect against ConA-induced liver injury by inhibiting autophagy, providing theoretical support for its potential use in clinical practice.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Gastroenterology & Hepatology
Jie Zhao, Yong-Fen Qi, Yan-Rong Yu
Summary: JAK protein tyrosine kinase is able to activate the STAT signaling pathway, with STAT3 playing a crucial role in the development of liver fibrosis. Activation of STAT3 can have different roles in the pathogenesis of liver fibrosis.
ANNALS OF HEPATOLOGY
(2021)
Article
Medicine, Research & Experimental
Yun Ding, Ziqiang Yu, Cuili Zhang
Summary: The study found that DATS has potential protective effects against Con A-induced acute liver injury in mice, possibly through inhibition of inflammation, oxidative stress, and apoptosis.
Article
Multidisciplinary Sciences
Jian Gan, Qin Gao, Li Li Wang, Ai Ping Tian, Long Dong Zhu, Li Ting Zhang, Wei Zhou, Xiao Rong Mao, Jun Feng Li
Summary: This study investigated the role of glucosylceramide synthase (GCS) in Con A-induced immune-mediated liver injury, revealing that GCS inhibition reduces the severity of liver damage, possibly due to its involvement in hepatocyte repair processes post-injury.
Article
Medicine, Research & Experimental
Xiangmin He, Kai Kang, Dan Pan, Yue Sun, Bing Chang
Summary: This study found that Fingolimod (FTY720) has a protective effect on acetaminophen (APAP)-induced liver injury (AILI). FTY720 regulates the JAK2/STAT3 signaling pathway to reduce immune cell recruitment and inflammation, inhibit cell apoptosis and oxidative stress, and attenuate liver tissue damage.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2022)
Article
Immunology
Fenglian Yan, Dalei Cheng, Haiyan Wang, Min Gao, Junfeng Zhang, Hongyan Cheng, Changying Wang, Hui Zhang, Huabao Xiong
Summary: The study demonstrates that corilagin has a protective effect against immune-mediated hepatic injury. Corilagin can protect the liver from damage by limiting the activation of M1 macrophages and regulating the MAPK, NF-kappa B, and IRF signaling pathways.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Wenchang Yang, Yaxin Wang, Peng Zhang, Xiong Sun, Xin Chen, Jiaxian Yu, Liang Shi, Yuping Yin, Kaixiong Tao, Ruidong Li
Summary: This study reveals the protective role of IRG1/itaconate in liver injury caused by Con A, and suggests its potential therapeutic strategy for immune liver injury by regulating inflammation, apoptosis, and oxidative stress.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Cell Biology
Yuanyuan Tian, Jiao Wang, Xiaori Qin, Shibing Li, Cheng Lan, Xiaoning Sun
Summary: Narciclasine (NCS) extracted from narcissus bulbs showed hepatoprotective effect against Con A induced hepatitis by suppressing T cell activation, suggesting a potential new approach for treating autoimmune hepatitis.
CELLULAR IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Hyo-Jeong Yun, Young-Joo Suh, Yu-Bin Kim, Eun-Jung Kang, Jung Hyeon Choi, Young-Keun Choi, In-Bok Lee, Dong-Hee Choi, Yun Jeong Seo, Jung-Ran Noh, Hueng-Sik Choi, Yong-Hoon Kim, Chul-Ho Lee
Summary: This study demonstrates that DAX1 deficiency exacerbates inflammatory liver injury by activating NF-kB p65 and modulating the expression of inflammatory chemokines and adhesion molecules. Therefore, DAX1 may serve as a therapeutic target for the treatment of fulminant hepatitis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Yan Li, Luping Gong, Linjie Weng, Xiuhe Pan, Chaobo Liu, Mingcai Li
Summary: Our study demonstrated that IL-39 exacerbates ConA-induced hepatitis by increasing serum ALT and AST levels, inflammatory infiltration, and hepatocyte necrosis. Additionally, IL-39 administration significantly elevated interferon-gamma, tumor necrosis factor-alpha, and IL-17A levels in ConA-induced hepatitis.
IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dingwu Li, Jianing Chen, Bingru Lin, Yanjun Guo, Jiaqi Pan, Chaohui Yu, Xingyong Wan
Summary: This study aimed to investigate the protective effect of celastrol on liver injury induced by ConA and its potential mechanisms. The results showed that pretreatment with celastrol significantly ameliorated liver injury and inhibited IL-17 signaling, suggesting the potential of celastrol in treating immune-mediated liver diseases.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Oncology
Carolin Ploeger, Johannes Schreck, Thorben Huth, Angelika Fraas, Thomas Albrecht, Alphonse Charbel, Junfang Ji, Stephan Singer, Kai Breuhahn, Stefan Pusch, Bruno Christian Koehler, Christoph Springfeld, Peter Schirmacher, Arianeb Mehrabi, Benjamin Goeppert, Stephanie Roessler
Summary: This study found that HCC tumor cells may activate both STAT1 and STAT3 signaling under pro-inflammatory conditions. In addition, the activation of STAT1 and STAT3 was highly correlated with immune cell infiltration and PD-L1 expression.
Article
Biochemistry & Molecular Biology
Ryuta Muromoto, Ami Sato, Yuki Komori, Kota Nariya, Yuichi Kitai, Jun-ichi Kashiwakura, Tadashi Matsuda
Summary: This study investigates how transcription factors C/EBPb and STAT1 regulate the NFKBIZ promoter, revealing opposing roles in NFKBIZ transcription.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Xiao Han, Ying Wang, Jing Sun, Tao Tan, Xiaomin Cai, Peinan Lin, Yang Tan, Bingfeng Zheng, Biao Wang, Jiawei Wang, Lingyan Xu, Zhengyi Yu, Qiang Xu, Xingxin Wu, Yanhong Gu
Article
Biochemistry & Molecular Biology
Rong Yu, Shiyu Wen, Qiaona Wang, Congying Wang, Liping Zhang, Xingxin Wu, Jianmei Li, Lingdong Kong
Summary: Mulberroside A can prevent neuroinflammatory injury caused by high fructose diet by reshaping gut dysbiosis, increasing SCFAs content, preventing IEB damage, and repairing BBB structure defects in mice.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Immunology
Bingfeng Zheng, Manman Yuan, Qinhai Ma, Shenglan Wang, Yang Tan, Yizhu Xu, Jing Ye, Yanjie Gao, Xueqing Sun, Zifeng Yang, Peipei Xu, Lingdong Kong, Xingxin Wu, Qiang Xu
Summary: The study suggests that human bone marrow cells may be strongly infected by SARS-CoV-2, potentially playing a significant role in the pathogenesis of COVID-19. The findings provide a deeper understanding of SARS-CoV-2 infection routes and may contribute to the development of treatments for COVID-19.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Microbiology
Tingting Wang, Jing Zhou, Jiabin Zou, Yutong Shi, Wenli Zhou, Peng Shao, Tianze Yu, Wei Cui, Xiaohui Li, Xingxin Wu, Jing Ye, Xiaojun Yan, C. Benjamin Naman, J. Enrico H. Lazaro, Shan He
Summary: Mesophotic coral ecosystems (MCEs) have complex and understudied biodiversity, especially in terms of natural products discovery. New compounds, including cymopolyphenols and phenylspirodrimanes, were isolated from marine sponge-associated fungi from different depths, showing potential biological activities such as antimicrobial and iron chelating properties. These findings highlight the importance of further research on the biodiversity and potential bioactive compounds from MCEs.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Chemistry, Medicinal
Jing Zhou, Hairong Zhang, Jing Ye, Xingxin Wu, Weiyi Wang, Houwen Lin, Xiaojun Yan, J. Enrico H. Lazaro, Tingting Wang, C. Benjamin Naman, Shan He
Summary: Two new polyketide natural products were isolated from a fungus derived from a deep-sea sponge, along with four known metabolites. One of the new compounds showed strong cytotoxicity against human acute lymphatic leukemia cells.
Article
Pharmacology & Pharmacy
Bingfeng Zheng, Manman Yuan, Shenglan Wang, Yang Tan, Yizhu Xu, Jing Ye, Yanjie Gao, Xueqing Sun, Tianyi Wang, Lingdong Kong, Xingxin Wu, Qiang Xu
Summary: Fraxinellone was found to alleviate kidney fibrosis by down-regulating the expression of CUGBP1 and inhibiting the activation of kidney fibroblasts, suggesting its potential as a new drug candidate for the treatment of kidney fibrosis. CUGBP1 could be a promising target for kidney fibrosis therapy.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Article
Oncology
Binglin Wang, Yi Wang, Xiaofan Sun, Guoliang Deng, Wei Huang, Xingxin Wu, Yanghong Gu, Zhigang Tian, Zhimin Fan, Qiang Xu, Hongqi Chen, Yang Sun
Summary: This study revealed that CXCR6 is exclusively expressed on intratumoral CD8(+) T cells, which are more immunocompetent and possess stronger antitumor activity. Additionally, CXCR6 may serve as a biomarker for tumor immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Medicinal
Ye Yuan, Te Li, Tingting Wang, C. Benjamin Naman, Jing Ye, Xingxin Wu, J. Enrico H. Lazaro, Xiaojun Yan, Shan He
Summary: The novel cyclic hexadepsipeptide cymodepsipeptide and two known analogues were isolated from a sponge-derived fungus using LC-MS/MS-based molecular networking. The structure of cymodepsipeptide was elucidated using various techniques, and it exhibited moderate cytotoxicity against human acute lymphocytic leukemia cells in vitro.
Article
Biochemistry & Molecular Biology
Yang Tan, Xueqing Sun, Yizhu Xu, Bingjie Tang, Shuaiqi Xu, Dong Lu, Yan Ye, Xiaomin Luo, Xu Diao, Fulong Li, Tianyi Wang, Jiayu Chen, Qiang Xu, Xingxin Wu
Summary: Compound 27 disrupts CELF1-RNA binding, promotes IFN-gamma secretion, and suppresses HSC activation. Compound 841, a derivative of compound 27, is identified as a selective CELF1 inhibitor. This study provides a novel strategy for treating liver fibrosis and other CELF1-mediated diseases.
NUCLEIC ACIDS RESEARCH
(2022)
Article
Chemistry, Medicinal
Yizhu Xu, Huanhuan Wu, Lei Huang, Bingxin Zhai, Xiaofei Li, Shuaiqi Xu, Xingxin Wu, Qihua Zhu, Qiang Xu
Summary: Targeting both PARP-1 and TNKS1/2 with dual inhibitors provides a promising strategy for expanding the clinical application of PARP-1 inhibitors and overcoming resistance. Compound I-9, a dual PARP-1/2 and TNKS1/2 inhibitor, exhibits excellent antitumor efficacy and shows potential as a novel agent for cancer therapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Xiaofei Li, Mingjie Lu, Manman Yuan, Jing Ye, Wei Zhang, Lingyan Xu, Xiaohan Wu, Bingqing Hui, Yuchen Yang, Bin Wei, Ciliang Guo, Min Wei, Jie Dong, Xingxin Wu, Yanhong Gu
Summary: In this study, a recombinant oncolytic adenovirus encoding CXCL10 was successfully constructed to recruit more T cells in the tumor microenvironment and enhance the antitumor effect of anti-PD-1 therapy.
Article
Chemistry, Multidisciplinary
Shan Huang, Cheng Ma, Jiahao Lin, Wenjing Wang, Yizhu Xu, Xingxin Wu, Jian-Rong Zhang, Jun-Jie Zhu
Summary: This study presents a new method for simultaneously quantitatively detecting telomerase activity and DNA methylation degree in cells, with spatial-based detection. The ratio of telomerase activity to DNA methylation significantly correlates with the efficacy of anticancer drugs, while no apparent linear relationship exists between individual detection targets and drug efficacy. This newly developed approach extends the technology toolbox for precision in medical and pharmaceutical analysis related to drug potency.
Meeting Abstract
Immunology
Xingxin Wu, Tao Tan, Qiang Xu
JOURNAL OF IMMUNOLOGY
(2020)
Meeting Abstract
Immunology
Qiang Xu, Wenjie Guo, Xingxin Wu, Yang Sun
JOURNAL OF IMMUNOLOGY
(2020)
Article
Pharmacology & Pharmacy
Chuan-Feng Tang, Hong Ding, Rui-Qing Jiao, Xing-Xin Wu, Ling-Dong Kong
EUROPEAN JOURNAL OF PHARMACOLOGY
(2020)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)