Article
Biochemistry & Molecular Biology
Rita Rosado-Ramos, Joana Godinho-Pereira, Daniela Marques, Ines Figueira, Tiago Fleming Outeiro, Regina Menezes, Claudia Nunes dos Santos
Summary: The study found that fisetin has neuroprotective effects and modulates cellular pathologies related to Parkinson's Disease, reducing the formation of PD hallmark inclusions and increasing dopamine transporter levels.
Article
Biochemistry & Molecular Biology
Chanchao Lorthongpanich, Thanapon Charoenwongpaiboon, Prapasri Supakun, Methus Klaewkla, Pakpoom Kheolamai, Surapol Issaragrisil
Summary: The study showed that fisetin can inhibit proliferation, migration, and osteogenic differentiation of human MSCs and SaOs-2 cells by reducing YAP activity, leading to downregulation of osteogenic genes and upregulation of fibroblast genes. Molecular docking and simulations suggest that fisetin may disrupt protein-protein interactions by occupying the TEAD pocket, indicating its potential role in regulating human osteogenesis.
Review
Nutrition & Dietetics
Robert Kubina, Kamil Krzykawski, Agata Kabala-Dzik, Robert D. Wojtyczka, Ewa Chodurek, Arkadiusz Dziedzic
Summary: Diet plays a crucial role in maintaining homeostasis, and plants and spices rich in flavonoids have been widely used in traditional medicine. Flavonols in our diet may prevent cancer by modulating important enzymes and receptors involved in various signaling pathways. Fisetin, a type of flavonol, has been extensively studied for its anticancer activity. This review summarizes the evidence-based research on fisetin's effects on different types of cancer, including its preventive and therapeutic effects, molecular targets, and mechanisms. It suggests that fisetin has the potential to become a complementary drug in cancer prevention and treatment, but more in-depth research is needed before entering clinical trials.
Review
Pharmacology & Pharmacy
Syed Shams Ul Hassan, Saptadip Samanta, Raju Dash, Tomasz M. Karpinski, Emran Habibi, Abdul Sadiq, Amirhossin Ahmadi, Simona Bungau
Summary: Fisetin, a flavonoid compound, exhibits potent antioxidant properties and protects cells against oxidative stress, reducing the risk of neuroinflammation and neurodegenerative diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sukriti Vishwas, Sachin Kumar Singh, Monica Gulati, Ankit Awasthi, Rubiya Khursheed, Leander Corrie, Rajan Kumar, Trudi Collet, Raimar Loebenberg, Omji Porwal, Saurabh Gupta, Niraj Kumar Jha, Piyush Kumar Gupta, Hari Prasad Devkota, Dinesh Kumar Chellappan, Gaurav Gupta, Jon Adams, Kamal Dua
Summary: Fisetin, a bioactive flavonoid found in apple and strawberry, has various pharmacological effects against diseases. However, its poor solubility, low bioavailability, and limited blood brain barrier permeability hinder its clinical research. Nanoformulations have been developed to enhance its efficacy.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Medicine, Research & Experimental
Hitesh Kumar, Pallavi Chand, Shantanu Pachal, Sahid Mallick, Rupshee Jain, SubbaRao V. Madhunapantula, Vikas Jain
Summary: Fisetin-loaded nanostructured lipid carriers (NLCs) were developed and optimized for better efficacy against metastatic melanoma. The NLCs showed suitable particle size, stability, sustained drug release, and significantly enhanced antitumor activity in cellular and animal experiments.
MOLECULAR PHARMACEUTICS
(2023)
Article
Integrative & Complementary Medicine
Zi-Shen Zhou, Chen-Fan Kong, Jian-Rong Sun, Xiang-Ke Qu, Jin-Hui Sun, An-Tao Sun
Summary: This study found that fisetin can prevent alcohol-induced liver toxicity by suppressing the activation of hepatic stellate cells (HSCs), promoting SIRT1-mediated autophagy, and inhibiting Sphk1-mediated endoplasmic reticulum stress (ER stress).
AMERICAN JOURNAL OF CHINESE MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Shanoo Suroowan, E. J. Llorent-Martinez, Gokhan Zengin, Asaad Khalid, Ashraf N. Abdalla, Soud Khogeer, Bao Van, Mohamad Fawzi Mahomoodally
Summary: This study investigated the phytochemical and pharmacological properties of Wikstroemia indica. The methanolic extract showed the highest content of phenolic compounds and exhibited the strongest antioxidant potential. The ethyl acetate extract and methanolic extract demonstrated good inhibitory activity against acetylcholinesterase, and the ethyl acetate extract also showed activity against butyrylcholinesterase. The tyrosinase and alpha amylase inhibitory potentials were confirmed, and the aqueous extract showed cytotoxicity against HT 29 cells.
PROCESS BIOCHEMISTRY
(2023)
Article
Food Science & Technology
Hanne Vissenaekens, Guy Smagghe, Hanne Criel, Charlotte Grootaert, Katleen Raes, Andreja Rajkovic, Geert Goeminne, Nico Boon, Kristof De Schutter, John Van Camp
Summary: The study demonstrates that quercetin can partially restore mitochondrial dysfunction, especially FCCP-induced dysfunction, in intestinal cells by accumulating in the mitochondria.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Masayuki Yamaga, Hiroko Tani, Miyu Nishikawa, Keisuke Fukaya, Shin-ichi Ikushiro, Kaeko Murota
Summary: This study investigated the pharmacokinetics and metabolism of Brazilian green propolis (BGP) components in humans, revealing that artepillin C and drupanin were the main substances with high concentrations in plasma, most of which were phenolic glucuronide conjugates. These findings provide valuable insights for further research on the mechanisms and pharmacological effects of BGP.
Article
Biochemistry & Molecular Biology
Nazia Afroze, Sreepoorna Pramodh, Jasmin Shafarin, Khuloud Bajbouj, Mawieh Hamad, Madhumitha Kedhari Sundaram, Shafiul Haque, Arif Hussain
Summary: Fisetin inhibits cell proliferation, promotes apoptosis, and improves oxidative stress and inflammation through regulating various signaling pathways, suggesting its potential therapeutic value in cancer management.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nanoscience & Nanotechnology
Onur Bulut, M. Deniz Yilmaz
Summary: In this study, a facile and convenient method was presented for the preparation of silver nanoparticles using quercetagetin as a reducing and stabilizing agent. The results showed that these silver nanoparticles exhibited excellent catalytic activity and could efficiently degrade a dye within a short period of time. Additionally, the silver nanoparticles demonstrated cytotoxic activity.
ACS APPLIED NANO MATERIALS
(2022)
Article
Chemistry, Applied
Gaobo Yu, Fengqiong Chen, Yating Wang, Qiusen Chen, Hanlin Liu, Jin Tian, Mengxue Wang, Chunyuan Ren, Qiang Zhao, Fengjun Yang, Yunyan Sheng, Jinpeng Wei, Yuxian Zhang
Summary: This study reveals that GABA effectively improves the nutritional quality of edamame by accumulating amino acids, bioactive peptides, isoflavones, anthocyanins, sugars, and organic acids. Exogenous GABA increases the metabolism of endogenous GABA and enhances the activity and expression of nitrogen metabolism-related enzymes, leading to an accumulation of amino acids and bioactive peptides. Additionally, exogenous GABA induces the metabolism of flavonoids by increasing the activity and expression of flavonoid biosynthetic enzymes.
Article
Multidisciplinary Sciences
Muhammad Umar Ijaz, Saqlain Haider, Arfa Tahir, Tayyaba Afsar, Ali Almajwal, Houda Amor, Suhail Razak
Summary: This study demonstrated the significant alleviative efficacy of Fisetin (FIS) against arsenic-induced reproductive damages, which was attributed to its antioxidant, anti-lipoperoxidative, anti-apoptotic, and androgenic effects.
SCIENTIFIC REPORTS
(2023)
Article
Food Science & Technology
Ahmed G. Darwish, Islam El-Sharkawy, Chunya Tang, Qinchun Rao, Juzhong Tan
Summary: This study investigated the total phenolic content, total flavonoid content, DPPH, FRAP antioxidant activity, and anticancer activity of muscadine grape pomace and chocolate extracts from three different muscadine genotypes on breast cancer cells. The extracts showed cytotoxicity activity against the cancer cells, with higher inhibition observed in the 'macerated Floriana' genotype. The study found a positive correlation between the total phenolic content of the extracts and the growth inhibition of African American breast cancer cells.
Article
Chemistry, Analytical
Rabah Gahoual, Gerard Bolbach, Ikram Ould-Melha, Gilles Clodic, Yannis-Nicolas Francois, Daniel Scherman, Nathalie Mignet, Pascal Houze
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS
(2020)
Article
Pharmacology & Pharmacy
Christine Fetro, Daniel Scherman
Article
Pharmacology & Pharmacy
Daniel Scherman, Christine Fetro
Article
Cell & Tissue Engineering
Yasmine Touil, Zacharie Segaoula, Xavier Thuru, Sylvie Galiegue-Zouitina, Dominique Tierny, Bruno Quesnel
STEM CELLS AND DEVELOPMENT
(2020)
Article
Medicine, Research & Experimental
Marie Pastor, Mickael Quiviger, Julie Pailloux, Daniel Scherman, Corinne Marie
MOLECULAR THERAPY-NUCLEIC ACIDS
(2020)
Article
Pharmacology & Pharmacy
Alena Libanska, Eva Randarova, Franck Lager, Gilles Renault, Daniel Scherman, Tomas Etrych
Article
Chemistry, Multidisciplinary
Jianhua Liu, Lenka Kotrchova, Thomas Lecuyer, Yohann Corvis, Johanne Seguin, Nathalie Mignet, Tomas Etrych, Daniel Scherman, Eva Randarova, Cyrille Richard
FRONTIERS IN CHEMISTRY
(2020)
Article
Multidisciplinary Sciences
Sandra Johnen, Nina Harmening, Corinne Marie, Daniel Scherman, Zsuzsanna Izsvak, Zoltan Ivics, Peter Walter, Gabriele Thumann
Summary: As society ages, neurodegenerative diseases are on the rise, making cell-based gene therapy a valuable option for treating diseases like AMD. The stable integration and continuous secretion of PEDF gene in PE cells through SB100X-mediated transfer offers a promising approach for gene addition therapy. Additionally, the random genomic distribution of the PEDF transposon in human PE cells provides valuable insights for further research.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2021)
Article
Chemistry, Multidisciplinary
Barbora Boltnarova, Jana Kubackova, Josef Skoda, Alzbeta Stefela, Monika Smekalova, Petra Svacinova, Ivona Pavkova, Milan Dittrich, Daniel Scherman, Jarmila Zbytovska, Petr Pavek, Ondrej Holas
Summary: In this study, various PLGA polymer nanospheres were prepared for macrophage-targeted drug delivery using nanoprecipitation and emulsification solvent evaporation methods. The larger nanospheres, prepared using nanoprecipitation, showed enhanced distribution into macrophages. The experimental PLGA nanoformulations surpassed the commercially available polymer in their capacity as macrophage-specific carriers, with no observed effects on cell viability or proinflammatory response.
Article
Biochemistry & Molecular Biology
Yasmine Touil, Celine Latreche-Carton, Hassiba El Bouazzati, Anne-Lucie Nugues, Nathalie Jouy, Xavier Thuru, William Laine, Frederic Lepretre, Martin Figeac, Meryem Tardivel, Jerome Kluza, Thierry Idziorek, Bruno Quesnel
Summary: In cancer cells, RIPK3 activity can induce p65/RelA cleavage and affect stemness markers, leading to increased tumor aggressiveness and alterations in cell metabolism.
JOURNAL OF CELLULAR BIOCHEMISTRY
(2022)
Article
Biochemical Research Methods
Faruk Azam Shaik, Clara Lewuillon, Aurelie Guillemette, Bahram Ahmadian, Carine Brinster, Bruno Quesnel, Dominique Collard, Yasmine Touil, Loic Lemonnier, Mehmet Cagatay Tarhan
Summary: Analyzing cell-cell interaction is crucial for understanding immune cell functions. This study introduces a method that uses hydrodynamic flow focusing to capture cells of different sizes and analyze their activities through calcium imaging.
Article
Multidisciplinary Sciences
Valerio Farfariello, Dmitri Gordienko, Lina Mesilmany, Yasmine Touil, Emmanuelle Germain, Ingrid Fliniaux, Emilie Desruelles, Dimitra Gkika, Morad Roudbaraki, George Shapovalov, Lucile Noyer, Mathilde Lebas, Laurent Allart, Nathalie Zienthal-Gelus, Oksana Iamshanova, Franck Bonardi, Martin Figeac, William Laine, Jerome Kluza, Philippe Marchetti, Bruno Quesnel, Daniel Metzger, David Bernard, Jan B. Parys, Loic Lemonnier, Natalia Prevarskaya
Summary: This study reveals the mechanism of how alterations in mitochondrial function and calcium signaling contribute to cellular senescence and tumor growth. The downregulation of TRPC3 protein in senescent fibroblasts leads to increased mitochondrial calcium load and oxidative phosphorylation, promoting cellular senescence. The downregulation of TRPC3 in stromal cells also affects secretome and tumor progression, highlighting its importance in cancer development.
NATURE COMMUNICATIONS
(2022)
Review
Cell Biology
Clara Lewuillon, Marie-Oceane Laguillaumie, Bruno Quesnel, Thierry Idziorek, Yasmine Touil, Loic Lemonnier
Summary: Acute myeloid leukemia (AML) is a clonal disorder characterized by genetic aberrations in myeloid primitive cells, resulting in their defective maturation/function and proliferation. The role of calcium signaling in AML cell proliferation and differentiation, as well as in the quiescence of hematopoietic stem cells, is significant but still not well understood.
Article
Biochemistry & Molecular Biology
Clara Lewuillon, Aurelie Guillemette, Sofia Titah, Faruk Azam Shaik, Nathalie Jouy, Ossama Labiad, Valerio Farfariello, Marie-Oceane Laguillaumie, Thierry Idziorek, Adeline Barthelemy, Pauline Peyrouze, Celine Berthon, Mehmet Cagatay Tarhan, Meyling Cheok, Bruno Quesnel, Loic Lemonnier, Yasmine Touil
Summary: This study reveals the importance of ORAI1/SOCE in AML, not only showing the association in cell lines but also confirming it in primary cells isolated from patients. Additionally, we found that SOCE varies according to differentiation status, ABCB1 activity level, and LSC proportion in these models.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Medicine, Research & Experimental
Marie-Oceane Laguillaumie, Clara Lewuillon, Yasmine Touil, Loic Lemonnier, Thierry Idziorek
Summary: AML is a type of leukemia characterized by genetic abnormalities in myeloid precursor cells, impairing their maturation and function. Although intensive chemotherapy can achieve complete remission in 50% to 80% of AML patients, relapse is common. Despite the well-known role of calcium signaling in cancer, there is limited research on calcium targets in AML. This study aims to emphasize on calcium channels and associated signaling pathways in AML, with the aim of developing targeted treatments.
M S-MEDECINE SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)