Article
Anatomy & Morphology
Ayse Cakir Gundogdu, Rumeysa Ozyurt
Summary: Epithelial sodium channels (ENaCs) play important roles in cancer progression, including proliferation, migration, invasion, and apoptosis. Inhibition of ENaCs may have therapeutic potential in cancer treatment. Resveratrol, a natural polyphenol, activates AMP-activated protein kinase (AMPK) and reduces ENaC abundance in cell membrane. However, the effects of resveratrol on ENaCs in cancer cells are unknown. This study investigated the effects of resveratrol on ENaCs in human colon cancer cells and found that resveratrol activates AMPK, inhibits ENaCs, decreases cell viability, and increases apoptosis. These findings suggest that ENaC inhibition through AMPK activation may contribute to the anti-cancer effects of resveratrol.
Article
Plant Sciences
Kai Wang, De-Zhi Hou, Yi-Ming Ouyang, Ping Ling
Summary: This study aimed to evaluate the effects of resveratrol in combination with paclitaxel on apoptosis and its underlying mechanisms in the Caco-2 colon cancer cell line. The results showed that resveratrol significantly enhanced the cytotoxic effects of paclitaxel, increased the expression levels of g-H2AX protein, and promoted apoptosis induction by increasing reactive oxygen species (ROS) levels, inducing oxidative DNA damage, and decreasing cellular antioxidant defense. Therefore, the combination of resveratrol and paclitaxel can enhance cellular cytotoxicity and induce potent apoptosis in cancer cell lines.
SOUTH AFRICAN JOURNAL OF BOTANY
(2023)
Review
Biochemistry & Molecular Biology
Alessandro Zucchi, Francesco Claps, Antonio Luigi Pastore, Alessandro Perotti, Andrea Biagini, Luana Sallicandro, Rosaria Gentile, Concetta Caglioti, Federico Palazzetti, Bernard Fioretti
Summary: Bladder cancer is a common urinary system tumor, especially in males. Surgery and intravesical instillations can eliminate it, but recurrences and progression are frequent. Therefore, adjuvant therapy should be considered. Resveratrol has shown potential as an adjuvant therapy for bladder cancer, with anti-proliferative effects at high concentrations and anti-angiogenic action at low concentrations. This review examines the standard therapeutic approach to bladder cancer, preclinical studies on resveratrol in bladder cancer xenotransplantation models, and discusses molecular signals, particularly the STAT3 pathway and angiogenic growth factor modulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Jung Yoon Jang, Eunok Im, Nam Deuk Kim
Summary: This paper comprehensively summarizes the effects of resveratrol on inducing programmed cell death (PCD) such as apoptosis, autophagy, and necroptosis, as well as the development of synthetic resveratrol derivatives and analogues as novel anticancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Medicinal
Chunhua Liang, Kefan Yi, Xu Zhou, Xiaoting Li, Caiyun Zhong, Hui Cao, Chunfeng Xie, Jianyun Zhu
Summary: This study found that resveratrol has anti-proliferative and apoptosis-inducing effects on lung cancer cells by disrupting cellular homeostasis through the destruction of the intracellular antioxidant pool and increasing reactive oxygen species production.
PHYTOTHERAPY RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Simran Patel, Khushi Sandha, Anushka Waingankar, Prachi Jain, Arundhati Abhyankar
Summary: Atropisomerism plays a significant role in drug discovery and development, especially in modulating the selectivity of inhibitors for cancer therapy. Considering the impact of stereogenic centers in such compounds is necessary for successful cancer drug development.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Review
Nutrition & Dietetics
Matteo Nadile, Maria Ilektra Retsidou, Katerina Gioti, Apostolos Beloukas, Evangelia Tsiani
Summary: Cervical cancer is a global health concern, with a high number of cases and deaths each year. Resveratrol, a natural substance found in plants, has shown potential anticancer properties. Studies have found that resveratrol can inhibit proliferation, induce cell cycle arrest, and promote apoptosis in cervical cancer cells. It can also reduce the expression of HPV oncoproteins and increase the levels of tumor suppressor p53. In vivo studies on mice have shown a reduction in tumor volume and weight with resveratrol treatment. Overall, resveratrol has the ability to target certain signaling molecules involved in cervical cancer cell proliferation and survival. Further research is needed to fully understand its potential in cervical cancer treatment.
Article
Oncology
Zeinab Faghfoori, Mohammad Hasan Faghfoori, Amir Saber, Azimeh Izadi, Ahmad Yari Khosroushahi
Summary: The study showed that different species of bifidobacteria exhibit anticancer activity on colorectal cancer cells by regulating the expression of anti-apoptotic and pro-apoptotic genes, potentially contributing to the prevention and treatment of colorectal cancer. Further research is needed to fully understand the mechanisms behind apoptosis induction by bifidobacteria species.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Helena Moreira, Anna Szyjka, Justyna Grzesik, Katarzyna Pelc, Magdalena Zuk, Anna Kulma, Fathi Emhemmed, Christian D. Muller, Kazimierz Gasiorowski, Ewa Barg
Summary: The recovery rate in patients with metastatic colorectal cancer is low due to drug resistance and the presence of colorectal cancer stem cells (CSCs). Phytochemicals like -celastrol and resveratrol have shown promise in colon cancer therapy due to their low toxicity and ability to interact with various biological targets. This study investigates the anticancer mechanisms of these compounds against metastatic colon cancer cells and their capacity to eradicate CSCs.
Article
Oncology
Yiannis Drosos, Eumorphia G. Konstantakou, Aggeliki-Stefania Bassogianni, Konstantinos-Stylianos Nikolakopoulos, Dimitra G. Koumoundourou, Sophia P. Markaki, Ourania E. Tsitsilonis, Gerassimos E. Voutsinas, Dimitrios Valakos, Ema Anastasiadou, Dimitris Thanos, Athanassios D. Velentzas, Dimitrios J. Stravopodis
Summary: Bladder cancer (BLCA) is a highly prevalent disease that is associated with increased morbidity, mortality, and cost. Strategies targeting critical components and processes in BLCA cells' evolutionary trajectories are needed. Microtubule dynamics play a vital role in the survival and growth of BLCA cells, and targeting this pathway shows therapeutic promise with paclitaxel treatment.
Article
Cell Biology
Hanmin Tang, Jing Wang, Xuehui Luo, Qi Wang, Jie Chen, Xinyue Zhang, Qiuting Li, Chengyi Gao, Yuesen Li, Suxia Han
Summary: The apoptosis-related gene prognostic index (ARGPI) can serve as a promising biomarker for determining the risk of colon cancer progression, as well as molecular and immune characteristics and chemotherapeutic benefit. Through molecular analysis, it is a reliable method to predict the prognosis of colon cancer patients and assist doctors in formulating more effective treatment strategies.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Xiaoying Qin, Honghong Luo, Yixuan Deng, Xintong Yao, Jie Zhang, Baicheng He
Summary: Resveratrol, a natural compound, exhibits anti-cancer activity against colon cancer cells by activating the Hippo/YAP signaling pathway and disrupting the interaction between YAP and TEAD, leading to inhibition of cell proliferation and induction of apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Ting-Ann Lin, Wei-Sheng Lin, Ya-Chun Chou, Kalyanam Nagabhushanam, Chi-Tang Ho, Min-Hisung Pan
Summary: The study demonstrates that OXY inhibits human colon cancer cell migration by regulating both EMT and miRNAs, suggesting its potential anti-metastatic properties in CRC.
Article
Nanoscience & Nanotechnology
Chaohui Zhang, Lin Chen, Qiang Bai, Lina Wang, Siheng Li, Ning Sui, Dongqin Yang, Zhiling Zhu
Summary: This article reports a metal-free ferroptosis-apoptosis inducer based on boron and nitrogen codoped graphdiyne, which has efficient GSH depletion capability and induces ferroptosis by deactivating GPX4 and apoptosis by downregulating Bcl2. The high catalytic activity of the inducer is explained by both experiments and DFT calculations, and a unique Bi-Bi mechanism is discovered.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Biochemistry & Molecular Biology
Doil Park, Ji Hoon Jung, Hyun Min Ko, Wona Jee, Hyungsuk Kim, Hyeung-Jin Jang
Summary: This study found that Cycloastragenol (CY) induces apoptosis through p53 activation and inhibits the proliferation of colon cancer cells. CY enhances p53 expression and is expected to have a synergistic effect when used in combination with existing treatments for colon cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Chun Wai Mui, Wai Nok Chan, Bonan Chen, Alvin Ho-Kwan Cheung, Jun Yu, Kwok Wai Lo, Huixing Ke, Wei Kang, Ka Fai To
Summary: This review summarizes the dysregulation of the Hippo-YAP1 pathway in lung carcinoma and discusses therapeutic strategies, while also providing research directions for future investigation.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Letter
Surgery
Sami Shoucair, Jun Yu
Article
Food Science & Technology
Yuanyuan Hu, Zhengqi Liu, Xiaoya Tao, Jinjin Li, Zuoxu Hou, Xiaoming Guo, Dayong Zhou, Mingfu Wang, Beiwei Zhu
Summary: This study investigated the toxic effects of tt-DDE exposure on human umbilical vein endothelial cells (HUVECs) and the potential protective effects of green tea catechins. The results showed that tt-DDE exposure induced pyroptosis and NLRP3 inflammasome activation in endothelial cells, while green tea catechins, particularly epigallocatechin-3-gallate (EGCG), effectively alleviated tt-DDE-induced cytotoxicity and dysfunction. These findings provide new insights into tt-DDE-induced endothelial injury and demonstrate the protective role of EGCG against tt-DDE-associated endothelial toxicity.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Oncology
Huan Yan, Jing-Ling Zhang, Kam-Tong Leung, Kwok-Wai Lo, Jun Yu, Ka-Fai To, Wei Kang
Summary: Gastric cancer is a highly life-threatening malignancy, particularly in Asian countries. Aberrant activation of G-protein-coupled receptors (GPCRs) and G proteins promotes the progression of gastric cancer. These activated GPCRs/G proteins can potentially serve as valuable biomarkers for early diagnosis and prognostic prediction, as well as therapeutic targets. This review summarizes the recent research progress of GPCRs and highlights their mechanisms in tumorigenesis, specifically in gastric cancer initiation and progression.
Article
Agriculture, Multidisciplinary
Hao Suo, Mohammad Rezaul Islam Shishir, Qi Wang, Mingfu Wang, Feng Chen, Ka Wing Cheng
Summary: This study found that red wine high-molecular-weight polyphenolic complexes (HPPCs) can inhibit key metabolic syndrome-associated enzymes and modulate human gut microbiota (GM) in vitro. Supplementation of HPPCs effectively attenuated high-fat diet-induced metabolic disturbance in mice, including obesity, insulin resistance, and dysregulation of lipid and glucose metabolism. It also improved the abundance of certain bacteria and the production of short-chain fatty acids, while modulating vitamin B metabolism-associated pathways. The findings suggest that dietary supplementation with red wine HPPCs may be a promising strategy for managing weight gain and metabolic dysregulation associated with high-fat diet.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2023)
Editorial Material
Gastroenterology & Hepatology
Rashid N. Lui, Sunny H. Wong, Nik Sheng Ding, Masau Sekiguchi, Jun Yu, Tiing-Leong Ang, Khay-Guan Yeoh, Han-Mo Chiu, Joseph J. Y. Sung
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yinnan Chen, Quanpeng Qiu, Junjun She, Jun Yu
Summary: Extrachromosomal circular DNA (ecDNA) is highly prevalent in various cancers, including colorectal cancer (CRC), and plays a critical role in regulating oncogene expression and resistance to therapy. Understanding the mechanisms and features of ecDNA in CRC provides insights into its pathogenesis and potential diagnostic and therapeutic implications. This review discusses the biogenesis, distinct features, and functional roles of ecDNA in CRC, including its involvement in oncogene overexpression, gene regulation, and topological interactions with active chromatin.
Article
Gastroenterology & Hepatology
Yali Liu, Harry Cheuk-Hay Lau, Jun Yu
Summary: Trillions of microbes in the human gastrointestinal tract form an ecological community known as the gut microbiota, which plays a crucial role in dietary digestion and produces various metabolites. However, these microbial metabolites have been found to be correlated with the development of colorectal cancer (CRC) and can also impact the efficacy of cancer treatments. This review discusses the role of metabolites derived from microbes-mediated metabolism of dietary components and their influence on CRC development, as well as their impacts on chemotherapy and immunotherapy. Targeting metabolites may be a promising therapeutic approach for improving patient outcome in CRC.
Review
Medicine, Research & Experimental
Heng-Chung Kung, Jun Yu
Summary: Pancreatic ductal adenocarcinoma (PDAC) is an aggressive and lethal malignancy with poor prognosis, mainly due to lack of early detection, complex signaling pathways and molecular mechanisms, dense and desmoplastic stroma, and immunosuppressive microenvironment. The neoadjuvant approach for PDAC treatment has shown promising benefits compared to upfront surgery, but certain aspects such as optimal regimen, use of radiotherapy, and patient selection still need further investigation.
Article
Oncology
Qing Li, Hung Chan, Wei-Xin Liu, Chang-An Liu, Yunfei Zhou, Dan Huang, Xuelian Wang, Xiaoxing Li, Chuan Xie, Wing Ying-Zhi Liu, Xian-Song Wang, Siu Kin Ng, Hongyan Gou, Liu-Yang Zhao, Winnie Fong, Lanping Jiang, Yufeng Lin, Guijun Zhao, Feihu Bai, Xiaodong Liu, Huarong Chen, Lin Zhang, Sunny Hei Wong, Matthew Tak Vai Chan, William Ka Kei, Jun Yu
Summary: Carnobacterium maltaromaticum is depleted in female patients with colorectal cancer, but supplementation with this bacterium in mice reduces intestinal tumor formation in a female-specific manner. Estrogen increases the attachment and colonization of C. maltaromaticum by promoting the colonic expression of SLC3A2. This bacterium interacts with other gut microbes, such as Faecalibacterium prausnitzii, to produce vitamin D and activate the VDR signaling pathway, which suppresses CRC.
Article
Chemistry, Applied
Yuting Su, Qian Zhou, Hui Xu, Manting Huang, Siqian Li, Jiayi He, Ka-Wing Cheng, Mingfu Wang
Summary: By developing the CM-Cur/QT complex, the solubility and stability of quercetin were improved, leading to enhanced bioavailability. The complex showed increased bio-accessibility and antioxidant efficacy during in vitro digestion, and facilitated the internalization of quercetin in macrophages, exerting a potential synergistic anti-inflammatory effect.
FOOD HYDROCOLLOIDS
(2024)
Editorial Material
Gastroenterology & Hepatology
Chi chun Wong, Jun Yu
Article
Gastroenterology & Hepatology
Xing Kang, Changan Liu, Yanqiang Ding, Yunbi Ni, Fenfen Ji, Harry Cheuk Hay Lau, Lanping Jiang, Joseph J. Y. Sung, Sunny H. Wong, Jun Yu
Summary: This study found that the probiotic species R. intestinalis has a protective effect against colorectal tumourigenesis by producing butyrate, and it can also enhance the efficacy of anti-PD-1 treatment. These findings provide evidence for the potential use of R. intestinalis as an adjuvant therapy for colorectal cancer.
Review
Oncology
Wing Sum Shin, Fuda Xie, Bonan Chen, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Ka Fai To, Wei Kang
Summary: Microbial influences, including viral and fungal infections, may contribute to gastric cancer development. Established players such as H. pylori and EBV, as well as gut bacteria like Lactobacillus and Streptococcus, and viruses like hepatitis B and C, and fungi like Candida albicans, have been shown to have potential impacts on gastric cancer. Advanced sequencing technologies provide insights into the complexities of the gastric microbiome and offer potential diagnostic and therapeutic applications for gastric cancer.
Review
Microbiology
Hao Su, Henley Cheung, Harry Cheuk-Hay Lau, Hongyan Chen, Xiaoting Zhang, Na Qin, Yifei Wang, Matthew Tak Vai Chan, William Ka Kei Wu, Huarong Chen
Summary: Understanding the interaction between gut microbiota and host RNA m6A modification provides valuable insights into the mechanisms and therapeutic strategies for cancer. The gut microbiota plays a crucial role in regulating host functions and has a significant impact on human health. Dysbiosis of the gut microbiota is associated with various diseases including cancer. The gut microbiota can influence cancer development through mechanisms such as cell regulation, immune response, and metabolic changes. Aberrant RNA m6A modifications have been shown to play a critical role in cancer development. This review aims to summarize the roles of gut microbiota and RNA m6A modifications in cancer and their potential interactions.
FEMS MICROBIOLOGY REVIEWS
(2023)
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
