Article
Oncology
Wangie Yu, Yunyun Chen, Nagireddy Putluri, Abdullah Osman, Cristian Coarfa, Vasanta Putluri, Abu H. M. Kamal, Jennifer Kay Asmussen, Panagiotis Katsonis, Jeffrey N. Myers, Stephen Y. Lai, Wuhao Lu, Clifford C. Stephan, Reid T. Powell, Faye M. Johnson, Heath D. Skinner, Jawad Kazi, Kazi Mokim Ahmed, Linghao Hu, Addison Threet, Matthew D. Meyer, James A. Bankson, Tony Wang, Jack Davis, Kirby R. Parker, Madison A. Harris, Mokryun L. Baek, Gloria V. Echeverria, Xiaoli Qi, Jin Wang, Andy I. Frederick, Alex J. Walsh, Olivier Lichtarge, Mitchell J. Frederick, Vlad C. Sandulache
Summary: We found that head and neck squamous cell carcinoma cells acquire cisplatin resistance through metabolic rewiring, including reduced KEAP1 gene activity, activation of the Nrf2 pathway, increased cell biomass and reducing equivalents, and enhanced glucose and glutamine metabolism. These metabolic changes result in reduced energy production and proliferation, leading to resistance to cisplatin.
BRITISH JOURNAL OF CANCER
(2023)
Article
Chemistry, Multidisciplinary
Muhammad Javed Iqbal, Zhongkui Li, Maroof Ahmad Khan, Yanhong Zhu, Wajid Hussain, Hao Su, Qi-Ming Qiu, Rizwan Shoukat, Hui Li
Summary: This study focused on the structural analysis of nucleotide constructs, particularly the A-motif structures, and successfully characterized three 1D coordination polymers through single crystal X-ray diffraction. The research highlighted the intermolecular recognition and interactions involved in the construction of the A-motif. Additionally, the study explored the chiralities of the complexes and confirmed the novel supramolecular chirality of extending axial chirality in complex 3.
Article
Cell Biology
Jing Li, Ruiqin Wu, Mingo M. H. Yung, Jing Sun, Zhuqing Li, Hai Yang, Yi Zhang, Stephanie S. Liu, Annie N. Y. Cheung, Hextan Y. S. Ngan, John C. Braisted, Wei Zheng, Huiqiang Wei, Yingtang Gao, Peter Nemes, Huadong Pei, David W. Chan, Yiliang Li, Wenge Zhu
Summary: The JAK2/STAT pathway is hyperactivated in many cancers, leading to poor clinical prognosis and drug resistance. The protease SENP1 interacts with and deSUMOylates JAK2, promoting JAK2 accumulation in the cytoplasm for activation, which is critical for platinum-resistance in ovarian cancer.
CELL DEATH & DISEASE
(2021)
Article
Microbiology
Zijian Guo, Yuanyuan He, Jian Xu, Ananya N. Benegal, Steven L. Brody, Michael D. Vahey
Summary: By tracking the spread of influenza virus from single infected cells, it was found that the surface protein neuraminidase (NA) plays a key role in controlling cellular coinfection. NA depletes viral receptors from infected and neighboring uninfected cells. In cases of low viral infectious potential, inhibition of NA increases the local spread of infection by increasing the viral load received by neighboring cells.
Article
Biochemistry & Molecular Biology
Henryk Mastalarz, Agnieszka Mastalarz, Joanna Wietrzyk, Magdalena Milczarek, Andrzej Kochel, Andrzej Regiec
Summary: Two new platinum(II) complexes (1 and 2) were synthesized and characterized using various analytical techniques. The cytotoxicity of these complexes against different cancer cell lines was evaluated, and their cellular platinum uptake and stability were determined. Complex 2 showed higher cytotoxic activity compared to cisplatin, while complex 1 exhibited varying activity against different cancer cell lines.
Article
Chemistry, Analytical
Liyuan Fan, Xianbing Ji, Guoqing Lin, Kai Liu, Shengfu Chen, Guanglong Ma, Weili Xue, Xiaoyu Zhang, Longgang Wang
Summary: The platinum nanoclusters stabilized by LP exhibited high catalytic oxidation activity, enabling sensitive detection of glucose and glutathione concentrations.
MICROCHEMICAL JOURNAL
(2021)
Article
Chemistry, Multidisciplinary
Lingling Xu, Nanhui Liu, Wenjun Zhan, Yu Deng, Zhaoxia Chen, Xiaoyang Liu, Ge Gao, Qian Chen, Zhuang Liu, Gaolin Liang
Summary: The study developed a near-infrared fluorescence probe Cy5.5-CBT-NPs for noninvasive and sensitive evaluation of cancer immunotherapy efficacy. The probe enabled real-time monitoring and enhancement of cytotoxic T lymphocytes (CTLs) responses against tumor cells.
Article
Chemistry, Multidisciplinary
Sonia Vela-Gallego, Bartosz Lewandowski, Jasper Moehler, Alonso Puente, David Gil-Cantero, Helma Wennemers, Andres de la Escosura
Summary: This study investigates the control and tuning of properties of biohybrid catalysts through self-assembly. By combining catalytic tripeptide, fatty acid, and nucleobase derivatives, the biohybrid catalysts form fibrillar structures and catalyze specific reactions in aqueous media. The interactions between nucleobases enhance the ordering of supramolecular structures and affect the catalytic activity and selectivity.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Engineering, Environmental
Guangrong Sun, Pei Guo, Han Yeong Kaw, Meijiao Zhou, Wei Wang
Summary: This study reports the identification of five halogenated nucleobases as emerging disinfection byproducts (DBPs) in drinking water, with 2-chloroadenine exhibiting significant toxicological risk. A solid phase extraction-ultraperformance liquid chromatography-tandem mass spectrometry method was developed to detect these DBPs, with detection frequencies ranging from 73 to 100% and maximum concentrations of up to 65.3 ng/L in representative drinking water samples. The cytotoxicity of 2-chloroadenine was found to be three times higher than that of the commonly found DBP 2,6-dichloro-1,4-benzoquinone. These findings provide important insights for further research on the mutagenicity and human health risk of halogenated nucleobase-DBPs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2023)
Article
Multidisciplinary Sciences
Simona Dalin, Beatrice Grauman-Boss, Douglas A. Lauffenburger, Michael T. Hemann
Summary: Combination drug regimens have shown promise in overcoming chemotherapy resistance in cancer patients. The phenomenon of collateral sensitivity, where resistance to one drug is accompanied by sensitivity to another, has gained attention as a potential strategy for designing rational combination regimens. This study investigated collateral sensitivities in subclones resistant to classical chemotherapy agents and found only one collateral sensitivity, suggesting the existence of multiple different states of resistance. The phenotypic and transcriptomic heterogeneity observed in drug resistant cell lines should be considered in future studies and chemotherapy design.
SCIENTIFIC REPORTS
(2022)
Article
Chemistry, Medicinal
Ayse Halic Poslu, Safak Esra Aslan, Gamze Koz, Esra Senturk, Omer Koz, Murat Senturk, Ayse Nalbantsoy, Aykut Oztekin, Deniz Ekinci
Summary: This study synthesized a series of derivatives and evaluated their cytotoxic activity and enzyme inhibitory potency. The results showed that one newly synthesized derivative exhibited high toxicity against prostate adenocarcinoma cells, and most derivatives had more effective inhibitory action than existing drugs. Therefore, these derivatives are potential drug candidates.
ARCHIV DER PHARMAZIE
(2023)
Article
Chemistry, Inorganic & Nuclear
Laia Rafols, Dana Josa, David Aguila, Leoni A. Barrios, Olivier Roubeau, Jordi Cirera, Vanessa Soto-Cerrato, Ricardo Perez-Tomas, Manuel Martinez, Arnald Grabulosa, Patrick Gamez
Summary: The newly synthesized compounds showed poor cytotoxic activities in cell cultures, but displayed improved activities in aged DMSO solutions. It was found that the compounds underwent transformation reactions in DMSO, ultimately forming cyclometalated species.
INORGANIC CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Theodoros Tsolis, Neofyta Nikolaou, Konstantinos Ypsilantis, Anastasia Kougioumtzi, Dimitrios Kordias, Angeliki Magklara, Achilleas Garoufis
Summary: The different heterobimetallic complexes showed varying stability and activity when studied for their biological properties. Coordination of 9-MeG led to decomposition of some complexes, forming new complexes, with (6)Cl exhibiting higher cytotoxicity in cancer cells.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2021)
Article
Oncology
Masakazu Sato, Sho Sato, Daisuke Shintani, Mieko Hanaoka, Aiko Ogasawara, Maiko Miwa, Akira Yabuno, Akira Kurosaki, Hiroyuki Yoshida, Keiichi Fujiwara, Kosei Hasegawa
Summary: This study found that two groups, classified based on clustering with a focus on metabolism-related genes and FAK activity, were associated with platinum resistance and poor prognosis in the TCGA-OV data.
Article
Chemistry, Analytical
Kodai Watanabe, Yuuta Fujikawa, Yuko Murakami-Tonami, Masaya Mori, Megumi Sakata, Hideshi Inoue
Summary: This article describes a highly selective fluorogenic GSTP1 substrate for visualizing and detecting intracellular GSTP1 activity in cancer cells that highly express GSTP1, which has potential applications in cancer imaging and therapy.
Editorial Material
Chemistry, Inorganic & Nuclear
Michael J. Hannon, Jan Reedijk
DALTON TRANSACTIONS
(2015)
Article
Biochemistry & Molecular Biology
Pablo Martinez-Bulit, Ariadna Garza-Ortiz, Edgar Mijangos, Lidia Barron-Sosa, Francisco Sanchez-Bartez, Isabel Gracia-Mora, Angelina Flores-Parra, Rosalinda Contreras, Jan Reedijk, Norah Barba-Behrens
JOURNAL OF INORGANIC BIOCHEMISTRY
(2015)
Article
Chemistry, Inorganic & Nuclear
Ali Alsalme, Mohammed Jaafar, Xue Liu, Fabian Dielmann, F. Ekkehardt Hahn, Khalid Al-farhan, Jan Reedijk
Article
Chemistry, Inorganic & Nuclear
Abderezak Addala, Fatima Setifi, Konstantin G. Kottrup, Christopher Glidewell, Zouaoui Setifi, Graham Smith, Jan Reedijk
Article
Chemistry, Inorganic & Nuclear
Mohammed Jaafar, Xue Liu, Fabian Dielmann, F. Ekkehardt Hahn, Khalid Al-Farhan, Ali Alsalme, Jan Reedijk
INORGANICA CHIMICA ACTA
(2016)
Article
Chemistry, Inorganic & Nuclear
Jan Reedijk
INORGANICA CHIMICA ACTA
(2016)
Article
Biochemistry & Molecular Biology
Rais Ahmad Khan, Andreia de Almeida, Khalid Al-Farhan, Ali Alsalme, Angela Casini, Mohamed Ghazzali, Jan Reedijk
JOURNAL OF INORGANIC BIOCHEMISTRY
(2016)
Article
Chemistry, Inorganic & Nuclear
Rais Ahmad Khan, Fabian Dielmann, Xue Liu, F. Ekkehardt Hahn, Khalid Al-Farhan, Ali Alsalme, Jan Reedijk
Article
Chemistry, Inorganic & Nuclear
Sanjit Nayak, Andrej Pevec, Colin C. Seaton, Patrick Gamez, Jan Reedijk
Article
Chemistry, Multidisciplinary
Lars Ohrstrom, Jan Reedijk
PURE AND APPLIED CHEMISTRY
(2016)
Article
Chemistry, Inorganic & Nuclear
Fouzia Lehchili, Fatima Setifi, Xue Liu, Anahid Saneei, Monika Kucerakova, Zouaoui Setifi, Michal Dusek, Morgane Poupon, Mehrdad Pourayoubi, Jan Reedijk
Article
Chemistry, Inorganic & Nuclear
Mohammed Jaafar, Andrej Pevec, Sebastiaan Akerboom, Ali Alsalme, Khalid Al-Farhan, Mohamed Ghazzali, Jan Reedijk
INORGANICA CHIMICA ACTA
(2014)
Article
Chemistry, Inorganic & Nuclear
Mohamed Ghazzali, Miftahul Khair, Khalid Al-Farhan, Jan Reedijk
INORGANICA CHIMICA ACTA
(2014)
Article
Biochemistry & Molecular Biology
Ariadna Garza-Ortiz, Palanisamy Uma Maheswari, Martin Lutz, Maxime A. Siegler, Jan Reedijk
JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY
(2014)
Article
Chemistry, Inorganic & Nuclear
Fatima Setifi, Zouaoui Setifi, Piotr Konieczny, Christopher Glidewell, Samia Benmansour, Carlos J. Gomez-Garcia, Fernande Grandjean, Gary J. Long, Robert Pelka, Jan Reedijk
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)
