Article
Chemistry, Physical
Jaya R. Lakkakula, Rui Werner Macedo Krause, Deepika Divakaran, Sagar Barage, Rohit Srivastava
Summary: The circulation time and solubility of 5-Fluorouracil have been prolonged and increased by complexing it with cyclodextrin and conjugating it onto gold nanoparticles to form 5Fu ICAu. The 5Fu-ICAu system showed higher cell inhibition rate on breast cancer cell lines due to the enhanced EPR effect allowing selective accumulation of nanoparticles at tumor sites.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Oncology
Mingzhi Zhu, Yanyan Wang, Fang Wang, Lin Li, Xinguang Qiu
Summary: This study revealed that circFBXL5 promotes 5-FU resistance in breast cancer by regulating the miR-216b/HMGA2 axis. Knockdown of circFBXL5 inhibited cell migration, invasion, and promoted apoptosis, indicating its role in mediating drug resistance. Furthermore, circFBXL5 interference decreased breast cancer tumor growth in a xenograft model.
CANCER CELL INTERNATIONAL
(2021)
Article
Oncology
Wing-Lok Chan, Cheuk-Wai Choi, Ian Yu-Hong Wong, Terence Hon-Ting Tsang, Adrian Tin-Chung Lam, Rosa Pui-Ying Tse, K. K. Chan, Claudia Wong, Betty Tze-Ting Law, Emina Edith Cheung, Siu-Yin Chan, Ka-On Lam, Dora Kwong, Simon Law
Summary: This study reviewed the long-term clinical outcomes and safety data of induction chemotherapy followed by surgery or definitive chemoradiotherapy in patients with locally advanced unresectable esophageal cancer. The results showed that patients who received subsequent surgery had significantly longer median overall survival compared to those who had definitive chemoradiotherapy or no definitive treatment. Induction chemotherapy followed by conversion surgery offered a chance of cure with long-term survival benefit and manageable toxicities in these patients.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Multidisciplinary Sciences
Vinu Krishnan, Kevin Peng, Apoorva Sarode, Supriya Prakash, Zongmin Zhao, Sergey K. Filippov, Kristina Todorova, Brittney R. Sell, Omar Lujano, Shirin Bakre, Anusha Pusuluri, Douglas Vogus, Kenneth Y. Tsai, Anna Mandinova, Samir Mitragotri
Summary: DOCTOR is a novel topical treatment for skin cancer that demonstrates high cancer-cell killing specificity and superior safety to healthy skin cells compared to conventional treatments. In vivo and ex vivo studies confirm its efficacy in treating cancerous lesions without irritation or systemic absorption, making it a safe and potent option for clinical use.
Article
Pharmacology & Pharmacy
Ahmed A. H. Abdellatif, Ahmed M. Mohammed, Imran Saleem, Mansour Alsharidah, Osamah Al Rugaie, Fatma Ahmed, Shaaban K. Osman
Summary: The present study developed an innovative method for treating breast cancer by using chitosan hydrogel for localized drug delivery. The modified hydrogel demonstrated excellent physicochemical properties and sustained release of the drug. Both in vitro and in vivo experiments showed that the hydrogel exhibited superior anticancer activity and reduced side effects.
Article
Biochemistry & Molecular Biology
Fatemeh Mawalizadeh, Ghorban Mohammadzadeh, Azam Khedri, Mojtaba Rashidi
Summary: This study found that the combination of Quercetin can enhance the apoptotic effect of 5-FU on breast cancer cells, reducing tumor cell colony formation. This combination therapy may be a potential approach for the treatment of breast cancer.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Cardiac & Cardiovascular Systems
Yuki Sahashi, Takahide Nawa
Summary: A 72-year-old male patient developed focal atrial tachycardia after receiving combination chemotherapy for hypopharyngeal cancer, which was successfully treated with radiofrequency catheter ablation.
CARDIOVASCULAR TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
S. Proietti, A. Cucina, A. Catizone, G. Ricci, A. Pensotti, M. Bizzarri
Summary: The study demonstrates that embryo fish extract SL amplifies the migratory inhibition triggered by 5-FU in cancer cells, and reverses the epithelial-mesenchymal transition phenotype. The combination of SL with 5-FU significantly reduces the invasive capability of tumor cells compared to 5-FU alone.
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES
(2021)
Article
Chemistry, Medicinal
Tianyu Chen, Hui Chen, Yichun Jiang, Qi Yan, Shuling Zheng, Min Wu
Summary: In this study, KLA-modified liposomes co-loaded with 5-fluorouracil and paclitaxel were developed and demonstrated to have enhanced anticancer activity against triple-negative breast cancer (TNBC). The liposomes showed improved drug delivery to mitochondria and induced mitochondria-mediated apoptosis. In a mouse model, the liposomes also exhibited favorable antitumor activity with targeted tumor and mitochondria delivery, without obvious systemic toxicity.
Article
Chemistry, Physical
Bose Allben Akash, Suganya Kanagaraj, Sumathi Sundaravadivelu, Govindaraj Sri Varalakshmi, Varnitha Manikantan, Archana Sumohan Pillai, Aleyamma Alexander, Israel V. M. V. Enoch
Summary: Metal nanoparticles have been widely used in drug delivery due to their simple nanoscale structures. In this study, we synthesized beta-cyclodextrin citrate-coated copper nanoparticles and characterized their size, surface control, and magnetic and near-infrared absorption characteristics. The nanoparticles showed a size of around 10 nm and a near-spherical morphology. We successfully loaded the chemotherapy molecule 5-fluorouracil into the nanoparticles with a high encapsulation efficiency. In vitro cytotoxic studies demonstrated that the copper nanoparticles could effectively deliver the drug to breast cancer cells, showing potential for biomedical applications.
JOURNAL OF MOLECULAR STRUCTURE
(2024)
Article
Pharmacology & Pharmacy
Qian Tang, Daquan Liu, Hongyuan Chen, Dongxiu He, Wei Pan, Qi Li, Weiquan Xie, Siwei Chen, Cuiyun Yu
Summary: This study investigates the co-delivery of the anticancer drug 5-fluorouracil (5-FU) and miR-205 to breast cancer cells using functionalized PAMAM. The functionalized PAMAM-based co-delivery system shows enhanced therapeutic efficacy compared to mono treatment. It provides reduced toxicity and improved targeting properties, making it a promising platform for breast cancer treatment.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2022)
Review
Cell Biology
Alireza Mafi, Malihe Rezaee, Neda Hedayati, Sara Diana Hogan, Russel J. Reiter, Mohammad-Hossein Aarabi, Zatollah Asemi
Summary: Combined chemotherapy is an effective treatment for cancer patients, as it combines multiple therapeutic agents to target different aspects of cancer. 5-FU is a widely used chemotherapy agent, while melatonin has shown anti-cancer properties. This review aims to evaluate the role of melatonin as a complementary agent with 5-FU-based chemotherapy and identify their common signaling pathways.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Oncology
Valerie Catherine Linz, Carina Schwanbeck, Slavomir Krajnak, Katharina Anic, Joerg Jaekel, Roxana Schwab, Marcus Schmidt, Heinz Schmidberger, Annette Hasenburg, Marco Johannes Battista
Summary: This study retrospectively investigated the use of cisplatin and mitomycin C/5-fluorouracil as radiosensitisers in patients with locally advanced vulvar cancer. The results showed that both radiosensitisers had comparable outcomes and toxicities.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Engineering, Chemical
Galia Lara-Sotelo, Lorenza Diaz, Rocio Garcia-Becerra, Euclides Avila, Heriberto Prado-Garcia, Gabriela Morales-Guadarrama, Maria de Jesus Ibarra-Sanchez, Jose Esparza-Lopez, Fernando Larrea, Janice Garcia-Quiroz
Summary: Breast cancer is the most common neoplasm in women worldwide, with 5-fluorouracil being a conventional chemotherapeutic agent, but may cause severe side effects. Research shows that using alpha-mangostin together with 5-fluorouracil can increase the anticancer effect, potentially allowing for reducing the dosage of 5-fluorouracil in breast cancer patients.
Article
Biochemistry & Molecular Biology
Malgorzata Milczarek, Tomasz Cierpial, Piotr Kielbasinski, Milena Malecka-Gieldowska, Marta Switalska, Joanna Wietrzyk, Maciej Mazur, Katarzyna Wiktorska
Summary: The combination of 5-fluorouracil and ISC has synergistic effects on triple-negative breast cancer, leading to enhanced antiproliferative effects and safety.
Article
Pharmacology & Pharmacy
Paola Orlandi, Marta Banchi, Francesca Vaglini, Marco Carli, Stefano Aringhieri, Arianna Bandini, Carla Pardini, Cristina Viaggi, Michele Lai, Greta Ali, Alessandra Ottani, Eleonora Vandini, Patrizia Guidi, Margherita Bernardeschi, Veronica La Rocca, Giulio Francia, Gabriella Fontanini, Mauro Pistello, Giada Frenzilli, Daniela Giuliani, Marco Scarselli, Guido Bocci
Summary: This study investigates the role of MC4R in melanoma and the use of the selective antagonist ML in combination with vemurafenib. The results show that ML can inhibit melanoma cell proliferation and induce apoptosis through the inhibition of ERK1/2 phosphorylation and reduction of BCL-XL expression. The combination of vemurafenib and ML exhibits a synergistic effect in vitro and inhibits tumor growth in vivo without causing adverse effects.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Conor J. Bloxham, Katina D. Hulme, Fabrizio Fierro, Christian Fercher, Cassandra L. Pegg, Shannon L. O'Brien, Simon R. Foster, Kirsty R. Short, Sebastian G. B. Furness, Melissa E. Reichelt, Masha Y. Niv, Walter G. Thomas
Summary: Bitter taste receptors (T2Rs) are a type of G protein-coupled receptors that allow humans to detect aversive and toxic substances. This study characterized the functional properties of previously identified T2Rs in human cardiac tissues and their naturally occurring polymorphisms. The results showed differences in signaling among different T2R variants, and revealed a potential association between the T2R50 Tyr203 variant and cardiovascular disease.
BIOCHEMICAL PHARMACOLOGY
(2024)
Article
Pharmacology & Pharmacy
Lu Chen, Huanying Shi, Wenxin Zhang, Yongjun Zhu, Haifei Chen, Zimei Wu, Huijie Qi, Jiafeng Liu, Mingkang Zhong, Xiaojin Shi, Tianxiao Wang, Qunyi Li
Summary: This study demonstrates that Carfilzomib exhibits potent anti-tumor activity against esophageal squamous cell carcinoma (ESCC) by triggering mitochondrial apoptosis and reprogramming cellular metabolism. It has been identified that activating transcription factor 3 (ATF3) plays a crucial role as a cellular target in ESCC cells treated with Carfilzomib. Overexpression of ATF3 effectively counteracts the effects of Carfilzomib on ESCC cell proliferation, apoptosis, and metabolic reprogramming. Furthermore, ATF3 mediates the anti-tumor activity of Carfilzomib, suggesting its potential as a therapeutic agent for ESCC.
BIOCHEMICAL PHARMACOLOGY
(2024)
Review
Pharmacology & Pharmacy
Xing Zhang, Xiang Li, Ran Xia, Hong-Sheng Zhang
Summary: This review summarizes recent progress on the mechanisms of ferroptosis resistance in cancer and highlights the role of redox status and metabolism. Combination therapy for ferroptosis has great potential in treating resistant malignant tumors.
BIOCHEMICAL PHARMACOLOGY
(2024)