期刊
BIOCHEMICAL PHARMACOLOGY
卷 76, 期 11, 页码 1395-1403出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2008.05.022
关键词
RNA binding protein; Subcellular localization; Splicing; Translation; IRES; Signaling pathway
资金
- INSERM Institut Claudius Regaud
- Fondation de France
- FRM
- National Sciences and Engineering Research Council of Canada (NSERC)
- Canadian Institutes of Health Research (CIHR)
- French ministry of research
Eukaryotic cells have developed multiple mechanisms to respond to different physiological cues, such as cellular stress, which allow the cells to adapt themselves to their new environment. The regulation of post-transcriptional gene expression is an important component of the cellular stress response and is mediated by mRNA binding proteins (mRBPs). Recently, several studies have shown that regulated subcellular localization of mRBPs upon diverse stimuli (such as cellular stress) provides an additional level of regulation for gene expression. (C) 2008 Elsevier Inc. All rights reserved.
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