How to find a leucine in a haystack? Structure, ligand recognition and regulation of leucine–aspartic acid (LD) motifs

FAK dimerization controls its kinase-dependent functions at focal adhesions

(2014) K. Brami-Cherrier et al.   EMBO JOURNAL

The role of focal adhesion kinase in the regulation of cellular mechanical properties

(2013) Claudia Tanja Mierke   PHYSICAL BIOLOGY

Structural Basis for Hijacking of Cellular LxxLL Motifs by Papillomavirus E6 Oncoproteins

(2013) K. Zanier et al.   SCIENCE

Cerebral cavernous malformations: from CCM genes to endothelial cell homeostasis

(2013) Andreas Fischer et al.   TRENDS IN MOLECULAR MEDICINE

In Vitro Phosphorylation of the Focal Adhesion Targeting Domain of Focal Adhesion Kinase by Src Kinase

(2012) Jennifer Cable et al.   BIOCHEMISTRY

Structural Basis for Paxillin Binding and Focal Adhesion Targeting of β-Parvin

(2012) Amy L. Stiegler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation

(2012) Aritro Sen et al.   JOURNAL OF CLINICAL INVESTIGATION

Noise in cellular signaling pathways: causes and effects

(2012) John E. Ladbury et al.   TRENDS IN BIOCHEMICAL SCIENCES

How focal adhesion kinase achieves regulation by linking ligand binding, localization and action

(2011) Stefan T Arold   CURRENT OPINION IN STRUCTURAL BIOLOGY

Molecular Recognition of Leucine-Aspartate Repeat (LD) Motifs by the Focal Adhesion Targeting Homology Domain of Cerebral Cavernous Malformation 3 (CCM3)

(2011) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Full activity of the deleted in liver cancer 1 (DLC1) tumor suppressor depends on an LD-like motif that binds talin and focal adhesion kinase (FAK)

(2011) G. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evidence that inhibition of BAX activation by BCL-2 involves its tight and preferential interaction with the BH3 domain of BAX

(2010) Bonsu Ku et al.   CELL RESEARCH

Crystal Structure of CCM3, a Cerebral Cavernous Malformation Protein Critical for Vascular Integrity

(2010) Xiaofeng Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Adhesion Dynamics by Calpain-mediated Proteolysis of Focal Adhesion Kinase (FAK)

(2010) Keefe T. Chan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

(2010) M. D. Schaller   JOURNAL OF CELL SCIENCE

NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1

(2010) Thomas Güttler et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Ancient origin of the integrin-mediated adhesion and signaling machinery

(2010) A. Sebe-Pedros et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2

(2009) James Lulo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Focal adhesion kinase: switching between GAPs and GEFs in the regulation of cell motility

(2009) Alok Tomar et al.   CURRENT OPINION IN CELL BIOLOGY

FAK Phosphorylation by ERK Primes Ras-Induced Tyrosine Dephosphorylation of FAK Mediated by PIN1 and PTP-PEST

(2009) Yanhua Zheng et al.   MOLECULAR CELL

The Pseudoactive Site of ILK Is Essential for Its Binding to α-Parvin and Localization to Focal Adhesions

(2009) Koichi Fukuda et al.   MOLECULAR CELL

Structural basis for leucine-rich nuclear export signal recognition by CRM1

(2009) Xiuhua Dong et al.   NATURE

Ca2+ binding by domain 2 plays a critical role in the activation and stabilization of gelsolin

(2009) S. Nag et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein-tyrosine kinase CAKβ/PYK2 is activated by binding Ca2+/calmodulin to FERM F2 α2 helix and thus forming its dimer

(2008) Takayuki Kohno et al.   BIOCHEMICAL JOURNAL

Paxillin nuclear-cytoplasmic localization is regulated by phosphorylation of the LD4motif: evidence that nuclear paxillin promotes cell proliferation

(2008) Jing-Ming Dong et al.   BIOCHEMICAL JOURNAL

Vinculin Tail Conformation and Self-Association Is Independent of pH and H906 Protonation†

(2008) Sean M. Palmer et al.   BIOCHEMISTRY

The Structure of α-Parvin CH2-Paxillin LD1 Complex Reveals a Novel Modular Recognition for Focal Adhesion Assembly

(2008) Xiaoxia Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

GIT1 Paxillin-binding Domain Is a Four-helix Bundle, and It Binds to Both Paxillin LD2 and LD4 Motifs

(2008) Ziwei M. Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Paxillin comes of age

(2008) N. O. Deakin et al.   JOURNAL OF CELL SCIENCE

Structural Insights into the Association between BCAR3 and Cas Family Members, an Atypical Complex Implicated in Anti-Oestrogen Resistance

(2008) Marie-Line Garron et al.   JOURNAL OF MOLECULAR BIOLOGY

Structures of Dimeric GIT1 and Trimeric β-PIX and Implications for GIT–PIX Complex Assembly

(2008) Oliver Schlenker et al.   JOURNAL OF MOLECULAR BIOLOGY

Transformation by Bovine Papillomavirus Type 1 E6 Requires Paxillin

(2008) R. Wade et al.   JOURNAL OF VIROLOGY

Nuclear Localization of Cytoplasmic Poly(A)-Binding Protein upon Rotavirus Infection Involves the Interaction of NSP3 with eIF4G and RoXaN

(2008) M. Harb et al.   JOURNAL OF VIROLOGY

Leupaxin, a Novel Coactivator of the Androgen Receptor, Is Expressed in Prostate Cancer and Plays a Role in Adhesion and Invasion of Prostate Carcinoma Cells

(2008) Silke Kaulfuss et al.   MOLECULAR ENDOCRINOLOGY

Structural Analysis of the Interactions Between Paxillin LD Motifs and α-Parvin

(2008) Sonja Lorenz et al.   STRUCTURE

Phosphorylation of Paxillin LD4 Destabilizes Helix Formation and Inhibits Binding to Focal Adhesion Kinase†

(2007) Craig M. Bertolucci et al.   BIOCHEMISTRY

Structural Basis for the Interaction between Focal Adhesion Kinase and CD4

(2007) Marie-Line Garron et al.   JOURNAL OF MOLECULAR BIOLOGY