Article
Pharmacology & Pharmacy
Yu Liu, Guojun Chu, Wenzhi Shen, Yuefan Zhang, Wei Xu, Yongsheng Yu
Summary: XMU-MP-1 protects the heart from I/R injury by modulating the Mst1/AMPK pathway, mitigating myocardial damage and inflammation, and preserving cardiac function in mice.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Peiyan Du, Bin Lu, Ling Zhao, Ying Yao, Wenjie Qian, Zhen Yu, Yan Cui, Sijiu Yu, Jiangfeng Fan
Summary: This study investigated the expression and distribution of key members of the Hippo signaling pathway in yak mammary glands. The results showed that the expression levels of these key members varied in different physiological conditions, suggesting their important role in regulating mammary gland development.
Article
Biochemistry & Molecular Biology
Junjie Wang, Ziping Qi, Yun Wu, Aoli Wang, Qingwang Liu, Fengming Zou, Beilei Wang, Shuang Qi, Jiangyan Cao, Chen Hu, Chenliang Shi, Qianmao Liang, Li Wang, Jing Liu, Wenchao Wang, Qingsong Liu
Summary: Insulin-producing pancreatic beta cell death is the fundamental cause of type 1 diabetes (T1D) and a contributing factor to type 2 diabetes (T2D). MST1 contributes to the progression of diabetes mellitus through apoptosis induction and acceleration of pancreatic beta cell dysfunction. Activation of AMPK has been suggested as a treatment option for metabolic diseases, making the pharmacological inhibition of MST1 and activation of AMPK simultaneously a promising approach for diabetes therapy.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Pathology
Jiyoon Jung, Jeong Won Kim, Gilhyang Kim, Joo Young Kim
Summary: In colorectal cancer patients, low expression of MST1/2 and negative expression of LATS1/2 are associated with poor differentiation, large tumor size, and worse overall survival. These findings suggest that MST1/2 and LATS1/2 may serve as prognostic indicators for colorectal cancer patients.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Neurosciences
Kaixin Zhu, Yibai Zhu, Xiaoxiang Hou, Wen Chen, Xiaolin Qu, Yelei Zhang, Zhenxing Li, Chunhui Wang, Jigang Chen, Liquan Lv, Junyu Wang, Danfeng Zhang, Lijun Hou
Summary: After traumatic brain injury, the formation of NETs in the PVN may be associated with sympathetic hyperactivity, which could be related to the activation of microglia cells and increased secretion of IL-1 beta via the hippo/MST1 pathway.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Xiang Jin, Lihua Zhu, Sheng Xiao, Zhuhong Cui, Jing Tang, Jiangyong Yu, Mingjun Xie
Summary: The downregulated expression of MST1 in BCa is closely associated with poor patient prognosis and may be an independent risk factor for BCa. Overexpression of MST1 significantly inhibits proliferation and migration, and promotes apoptosis of BCa cells. Additionally, MST1 may inhibit BCa progression by targeting the Hippo signaling pathway.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Integrative & Complementary Medicine
Ning Zhang, Tao Ye, Xu Lu, Zi-hui Li, Ling Li
Summary: The study aimed to investigate the mechanism of Radix Scrophulariae extracts in the treatment of hyperthyroidism by regulating proliferation, apoptosis, and autophagy of thyroid cells through the MST1/Hippo pathway. The results showed that Radix Scrophulariae extracts could inhibit proliferation and promote apoptosis and autophagy in thyroid tissues for treating hyperthyroidism.
CHINESE JOURNAL OF INTEGRATIVE MEDICINE
(2023)
Article
Oncology
Xi Liu, Jun Quan, Zhaolong Shen, Zequn Zhang, Zhijian Chen, Liang Li, Xiaorong Li, Gui Hu, Xiaofeng Deng
Summary: This study found that MT2A was downregulated in CRC and was associated with the tumor M stage. MT2A overexpression inhibited CRC cell proliferation and migration, as well as growth and metastasis in animal models. MT2A overexpression promoted the phosphorylation of MST1, LAST2, and YAP1, thereby inhibiting the Hippo signaling pathway. Thus, MT2A and MST1 may be potential therapeutic targets for CRC patients.
CANCER CELL INTERNATIONAL
(2022)
Review
Cell Biology
Simon J. Cook, Pamela A. Lochhead
Summary: The RAS-regulated RAF-MEK1/2-ERK1/2 signaling pathway is frequently dysregulated in human cancer, particularly melanoma. Although three BRAFi have been approved for treating BRAF mutant melanoma and have shown significant impact, clinical responses are typically transient. Therefore, BRAFi are often used in combination with MEKi to provide more durable but still transient clinical responses. Recent studies have shown that activation of the ERK5 signaling pathway may result in resistance to BRAFi/MEKi and ERK1/2i.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Cell Biology
Xiaoliang Zhou, Hao Wang, Deguan Li, Naling Song, Fujun Yang, Wenqing Xu
Summary: Research has found that the MST1/2 inhibitor XMU-MP-1 can rescue impaired hematopoietic stem cells and progenitor cells under oxidative stress, alleviate intestinal injury caused by radiation, and prolong the survival of mice exposed to lethal doses of radiation.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Eva Louise Steinmetz, Denise Nicole Dewald, Uwe Walldorf
Summary: The study identified Hipk as a kinase that phosphorylates Yki, mapping several phosphorylation sites of Yki. These sites potentially provide additional regulation for Yki in vivo, with transgenic flies exhibiting notable phenotypes. Hipk is therefore an additional upstream regulator of Yki working in conjunction with Wts.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Cell Biology
Emel Rothzerg, Evan Ingley, Benjamin Mullin, Wei Xue, David Wood, Jiake Xu
Summary: Osteosarcoma is a primary malignant bone tumour that mainly affects children and adolescents, often caused by dysregulation of cellular functions. The Hippo signalling pathway plays a crucial role in this process, and small molecule inhibitors targeting this pathway hold promise for the treatment of osteosarcoma.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jeonggeun Lee, Namkyu Lee, Hee Dong Han, YoungJoo Lee
Summary: The incidence of endometrial cancer is rising, mainly due to hormone imbalance. Hypoxia has been found to play an important role in the proliferation and cell death of endometrial cancer cells, involving HIF-1 alpha and the Hippo signaling pathway.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Thomas J. Koehler, Thao Tran, Kyler A. Weingartner, Jennifer M. Kavran
Summary: In this study, the ability of MST2 to phosphorylate a peptide substrate and its regulation were investigated using a steady-state kinetic system. It was found that the SARAH domain of unphosphorylated MST2 stabilizes interactions with a peptide substrate and promotes its phosphorylation. Phosphorylation drives the activity of MST2, and the phosphorylated, caspase-cleaved MST2 is as active as the full-length one.
Article
Toxicology
Hengyang Shen, Yixuan Meng, Tao Hu, Shuwei Li, Mulong Du, Junyi Xin, Dongying Gu, Meilin Wang, Zan Fu
Summary: The study identified a novel colorectal cancer susceptibility locus, SCRIB rs13251492, associated with a decreased risk of colorectal cancer and longer recurrence-free survival time. Functional analyses revealed the influence of rs13251492 on the expression of SCRIB mRNA in colorectal tumors and its enhancer activity. High expression levels of SCRIB mRNA in colorectal cancer tissues compared to normal tissues further supported its functional relevance in cancer.
ARCHIVES OF TOXICOLOGY
(2021)