Article
Biochemistry & Molecular Biology
Valeria Schiavone, Tea Romasco, Nadia Di Pietrantonio, Stefania Garzoli, Carola Palmerini, Pamela Di Tomo, Caterina Pipino, Domitilla Mandatori, Rossella Fioravanti, Elena Butturini, Manuela Sabatino, Maria Pompea Antonia Baldassarre, Rino Ragno, Assunta Pandolfi, Natalia Di Pietro
Summary: Essential oils derived from aromatic plants have been found to improve the lipid and glycemic profile of patients with diabetes mellitus. This study investigated the potential anti-inflammatory effect of anise and laurel essential oils on endothelial cells isolated from females with gestational diabetes mellitus. The results showed that both essential oils significantly reduced monocyte adhesion, VCAM-1 expression, and NF-κB p65 nuclear translocation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Plant Sciences
Yun Jung Lee, Yong Pyo Lee, Chang Seob Seo, Eun Sik Choi, Byung Hyuk Han, Jung Joo Yoon, Se Hoon Jang, Chae Ghang Jeong, Yeun Ja Mun, Dae Gill Kang, Ho Sub Lee
Summary: The ethanol extract of Carthamus tinctorius L. (ECT) can alleviate vascular inflammatory processes by reducing cell adhesion molecules and oxidative stress, inhibiting NF-kappa B activation, and regulating the Nrf-2/HO-1 signaling axis. Further research is needed to determine the specific compound responsible for protecting against vascular diseases.
Article
Surgery
Wan Zhang, Zhenyu Guo, Li Li, Zhenyu Shi, Ting Zhu
Summary: This study explores the role of c-fos in the phenotypic switching of vascular smooth muscle cells (VSMCs) under hypoxic conditions. It reveals that hypoxia promotes the phenotypic transformation of VSMCs through the ERK1/2/c-fos/NF-κB signaling pathway. Inhibition of the ERK1/2 and NF-κB signaling pathways can attenuate hypoxia-mediated phenotypic transformation. The findings provide a novel insight into hypoxia-associated venous wall remodeling and may contribute to the development of new therapeutic targets for varicose veins (VVs).
ANNALS OF VASCULAR SURGERY
(2022)
Article
Agriculture, Multidisciplinary
Guanzhen Gao, Saya Nakamura, Sumire Asaba, Yuji Miyata, Hisayuki Nakayama, Toshiro Matsui
Summary: This study investigated the mechanism of vasorelaxant Mas receptor (MasR) expression elevated by hesperidin in spontaneously hypertensive rats in human umbilical vein endothelial cells (HUVECs). The results showed that hesperidin may stimulate TRPV1-mediated cascades, leading to the activation of two signaling axes, CaMKII/p38 MAPK/MasR expression and CaMKII/eNOS/NO production in HUVECs.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Biotechnology & Applied Microbiology
Qian Zhang, Wei Zhang, Jing Liu, Haisen Yang, Yuxia Hu, Mengdi Zhang, Tuya Bai, Fuhou Chang
Summary: The study investigated the regulatory role of LPC on endothelial cell adhesion marker expression, suggesting that the LPC-G2A-ICAM-1/VCAM-1 pathway may contribute to atherogenic activity of oxLDL, with NF-kappa B antagonists potentially serving as effective therapeutic tools for cardiovascular diseases.
Article
Biochemistry & Molecular Biology
Tzou-Yien Lin, Tsong-Min Chang, Wei-Cheng Tsai, Yi-Ju Hsieh, Li-Ting Wang, Huey-Chun Huang
Summary: The protective effects of extracellular vesicles derived from human umbilical cord mesenchymal stem cells (UCMSC-EVs) against oxazolone-induced damage in HaCaT cells were investigated. UCMSC-EVs pretreatment elevated cell viability, reduced intracellular ROS, and prevented changes in mitochondrial membrane potential. Furthermore, UCMSC-EVs exhibited anti-inflammatory activity by reducing the expression of inflammatory cytokines.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Tzou-Yien Lin, Tsong-Min Chang, Huey-Chun Huang
Summary: This study reveals that extracellular vesicles derived from human umbilical cord mesenchymal stem cells can inhibit IgE-stimulated mast cell activation and reduce cell degranulation and the release of inflammatory cytokines. Additionally, extracellular vesicles can also inhibit the activation of certain signaling pathways induced by IgE.
Review
Genetics & Heredity
Cheng Shen, Zhan Chen, Jie Jiang, Yong Zhang, Wei Xu, Rui Peng, Wenjing Zuo, Qian Jiang, Yihui Fan, Xingxing Fang, Bing Zheng
Summary: This study constructs a prognostic signature consisting of eight CTZFLs, which can predict the prognosis of clear cell renal cell carcinoma (ccRCC) patients and help with medication selection. In ccRCC, the high-risk group has a poorer prognosis, and there are significant differences in immune function, immune cell score, and immune checkpoint expression between the high-risk and low-risk groups.
FRONTIERS IN GENETICS
(2022)
Review
Oncology
Aneri Shah, Jonathan A. Lindquist, Lars Rosendahl, Ingo Schmitz, Peter R. Mertens
Summary: YB-1 is a RNA binding protein involved in various cellular processes, its activation is associated with NF-kappa B and can affect the inflammatory response and cell survival mechanisms.
Article
Immunology
Lu Jiang, Aidi Yang, Xi Li, Ke Liu, Jin Tan
Summary: Transplanting VCAM-1-silenced BMSCs into MI rats resulted in more significant reductions in myocardial infarct size and myocardial cell apoptosis, improved cardiac function, increased number of rats surviving within 72 hours, and extended survival time within 72 hours, possibly due to the down-regulation of NF-kappa B-regulated gene products.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Cell Biology
Chao Zhu, Wei Chen, Haiming Cui, Zhigang Huang, Ru Ding, Na Li, Qinqin Wang, Feng Wu, Yanmin Zhao, Xiaoliang Cong
Summary: Oxidized low-density lipoprotein (ox-LDL) promotes the expression of TRIM64, enhancing the activation of NLRP3 inflammasomes and the expression of downstream molecules. TRIM64 interacts with I kappa B alpha, promoting I kappa B alpha ubiquitination to activate the NF-kappa B signaling pathway. TRIM64 and NF-kappa B form a positive feedback mechanism in the development of atherosclerosis.
CELL BIOLOGY AND TOXICOLOGY
(2023)
Article
Pharmacology & Pharmacy
Wei Liu, Yanghui Ou, Yumeng Yang, Xuemei Zhang, Liqi Huang, Xiaohua Wang, Buling Wu, Mingcheng Huang
Summary: The study demonstrated that punicalagin has a protective effect on HUVECs activation through an endothelial-mediated mechanism, which may be used in the treatment of various disorders such as cancer, rheumatoid arthritis, and cardiovascular disease. This effect is achieved by reducing adhesion of monocyte cells to HUVECs, decreasing expression of ICAM-1 and VCAM-1, and inhibiting permeability, proliferation, migration, and tube formation in VEGF-induced HUVECs. Additionally, punicalagin suppresses IKK-mediated activation of NF-kappa B signaling and inhibits VEGFR2 activation and downstream p-PAK1.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Chia-Chia Chao, Wei-Fang Lee, Wei-Hung Yang, Chih-Yang Lin, Chien-Kuo Han, Yuan-Li Huang, Yi-Chin Fong, Min-Huan Wu, I-Ta Lee, Yuan-Hsin Tsai, Chih-Hsin Tang, Ju-Fang Liu
Summary: IGFBP-3 levels were found to be significantly higher in osteosarcoma tissue compared to normal tissue, and IGFBP-3 promoted cell migration in osteosarcoma cells by upregulating VCAM-1 expression through PI3K/Akt and AP-1 signaling pathways, suggesting IGFBP-3 as a potential therapeutic target in metastatic osteosarcoma.
Article
Fisheries
Yingying Zhang, Jiahui Xu, Jiyue Yu, Lingjun Si, Linrui Chang, Ting Li, Dongchun Yan
Summary: A novel CCCH-type zinc finger antiviral protein 1 (ZAP) gene was identified from Pacific white shrimp, which showed high similarity to mammalian ZAP proteins. In response to IHHNV infection, PvZAP gene expression was significantly up-regulated in the hepatopancreas and gills of both adult and juvenile shrimps. These results suggest that PvZAP plays a crucial role in the innate immune defense against IHHNV infection in Pacific white shrimp.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Food Science & Technology
Ae Sin Lee, Jinyoung Hur, Sang Yoon Choi
Summary: This study demonstrates that isobavachalcone inhibits TNF-α-induced vascular inflammation and has the potential to protect against the early progression of atherosclerosis.
APPLIED BIOLOGICAL CHEMISTRY
(2022)
Article
Cardiac & Cardiovascular Systems
Lin Chang, Wenhao Xiong, Xiangjie Zhao, Yanbo Fan, Yanhong Guo, Minerva Garcia-Barrio, Jifeng Zhang, Zhisheng Jiang, Jiandie D. Lin, Y. Eugene Chen
Article
Cardiac & Cardiovascular Systems
Yanbo Fan, Haocheng Lu, Wenying Liang, Minerva T. Garcia-Barrio, Yanhong Guo, Ji Zhang, Tianqing Zhu, Yibai Hao, Jifeng Zhang, Y. Eugene Chen
CIRCULATION RESEARCH
(2018)
Article
Multidisciplinary Sciences
Congzhen Qiao, Shengdi Li, Haocheng Lu, Fan Meng, Yanbo Fan, Yanhong Guo, Y. Eugene Chen, Jifeng Zhang
SCIENTIFIC REPORTS
(2018)
Article
Cardiac & Cardiovascular Systems
Wenting Hu, Haocheng Lu, Jifeng Zhang, Yanbo Fan, Ziyi Chang, Wenying Liang, Huilun Wang, Tianqing Zhu, Minerva T. Garcia-Barrio, Daoquan Peng, Y. Eugene Chen, Yanhong Guo
Letter
Cardiac & Cardiovascular Systems
Xiao Du, Shilan Zhang, Ling Liu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2018)
Article
Hematology
Wenying Liang, Yanbo Fan, Haocheng Lu, Ziyi Chang, Wenting Hu, Jinjian Sun, Huilun Wang, Tianqing Zhu, Jintao Wang, Reheman Adili, Minerva T. Garcia-Barrio, Michael Holinstat, Daniel Eitzman, Jifeng Zhang, Y. Eugene Chen
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Article
Medical Laboratory Technology
Feng Tian, Qun-yan Xiang, Ming-yu Zhang, Yan-qiao Chen, Qiu-zhen Lin, Tie Wen, Ling Liu
CLINICA CHIMICA ACTA
(2019)
Letter
Cardiac & Cardiovascular Systems
Feng Tian, Ya-ting Wang, Xiao Du, Shi-lan Zhang, Ling Liu
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2019)
Article
Medicine, General & Internal
Oren Rom, Guan Xu, Yanhong Guo, Yunhao Zhu, Huilun Wang, Jifeng Zhang, Yanbo Fan, Wenying Liang, Haocheng Lu, Yuhao Liu, Michael Aviram, Zhipeng Liu, Seongho Kim, Wanqing Liu, Xueding Wang, Y. Eugene Chen, Luis Villacorta
Article
Cell Biology
Haocheng Lu, Jinjian Sun, Wenying Liang, Jifeng Zhang, Oren Rom, Minerva T. Garcia-Barrio, Shengdi Li, Luis Villacorta, Francisco J. Schopfer, Bruce A. Freeman, Y. Eugene Chen, Yanho Fan
PHYSIOLOGICAL GENOMICS
(2019)
Article
Medical Laboratory Technology
Qiu-zhen Lin, Yan-qiao Chen, Li-Ling Guo, Qun-Yan Xiang, Feng Tian, Tie Wen, Ling Liu
CLINICA CHIMICA ACTA
(2019)
Letter
Cardiac & Cardiovascular Systems
Xiao Du, Shilan Zhang, Ling Liu
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Jin Xu, Yan-Qiao Chen, Shui-Ping Zhao, Ling Liu
LIPIDS IN HEALTH AND DISEASE
(2019)
Article
Medical Laboratory Technology
Qun-yan Xiang, Feng Tian, Qiu-zhen Lin, Xiao Du, Shi-lan Zhang, Ya-jun Gui, Li-ling Guo, Jin Xu, Li-yuan Zhu, Tie Wen, Ling Liu
CLINICA CHIMICA ACTA
(2020)
Meeting Abstract
Hematology
Jinjian Sun, Haocheng Lu, Wenying Liang, Ziyi Chang, Die Hu, Jifeng Zhang, Y. Eugene Chen, Yanbo Fan
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)