Article
Multidisciplinary Sciences
Samuel Hume, Claudia P. Grou, Pauline Lascaux, Vincenzo D'Angiolella, Arnaud J. Legrand, Kristijan Ramadan, Grigory L. Dianov
Summary: Efficient entry into S phase of the cell cycle is controlled by the NUCKS1-SKP2-p21/p27 axis. This pathway integrates mitogenic and DNA damage signals to regulate cell cycle progression, with potential implications in cancer development.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jinhong Mei, Yu Liu, Yiyun Sheng, Ying Liu, Limin Chen, Hailong Wang, Minzhang Cheng, Zhenyu Zhai, Linlin Xu
Summary: The study reveals that activating transcription factor 1 (ATF1) plays a critical role in the progression of lung adenocarcinoma by transcriptionally enhancing zinc finger protein 143 (ZNF143) expression, leading to increased proliferation and migration of lung adenocarcinoma cells. High expressions of ATF1 and ZNF143 are associated with poor disease-free survival in lung adenocarcinoma patients. This study provides a potential therapeutic candidate for the treatment of lung adenocarcinoma.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Multidisciplinary Sciences
Richard J. Acton, Wei Yuan, Fei Gao, Yudong Xia, Emma Bourne, Eva Wozniak, Jordana Bell, Karen Lillycrop, Jun Wang, Elaine Dennison, Nicholas Harvey, Charles A. Mein, Tim D. Spector, Pirro G. Hysi, Cyrus Cooper, Christopher G. Bell
Summary: The study found a discreet hypermethylation of genomic loci of human tRNA with advancing age, potentially impacting ageing-related disease.
NATURE COMMUNICATIONS
(2021)
Article
Medicine, Research & Experimental
Qian Shi, Ying He, Shouyu He, Jingjing Li, Ji Xia, Tianwei Chen, Lixia Huo, Yuhang Ling, Qinchen Liu, Wei Zang, Qiang Wang, Chengwu Tang, Xiang Wang
Summary: This study identified a novel long noncoding RNA (lncRNA) RP11-296E3.2 associated with colorectal cancer (CRC) metastasis and investigated its mechanisms in colorectal tumorigenesis. The results showed that RP11-296E3.2 was associated with CRC cell proliferation and metastasis by directly binding to Y-Box Binding Protein 1 (YBX1) and enhancing the transcription and phosphorylation of signal transducer and activator of transcription 3 (STAT3). The RP11-296E3.2/YBX1/STAT3 pathway is crucial for promoting colorectal tumorigenesis and progression.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Cell Biology
Yun Ha Hur, Shi Feng, Kristin F. Wilson, Richard A. Cerione, Marc A. Antonyak
Summary: Exposure of embryonic stem cells to extracellular vesicles derived from ESCs helps maintain their stem cell properties, preventing differentiation and preserving the ability to generate chimeric mice. These effects are mediated by fibronectin bound to the surfaces of EVs, which interact with ESC-associated integrins and activate FAK effectively.
DEVELOPMENTAL CELL
(2021)
Article
Biotechnology & Applied Microbiology
Xue-Ming Wang, Xiu-Mei Liu, Yuting Wang, Zhen-Yu Chen
Summary: ATF3 is significantly upregulated in keloid tissues, promoting cell proliferation and collagen production while reducing apoptosis rate. ATF3 enhances growth and invasion, inhibits apoptosis through the TGF-beta/Smad pathway in keloid fibroblast cells, suggesting its potential as a therapeutic target for keloid management.
Article
Multidisciplinary Sciences
Brian DeVeale, Leqian Liu, Ryan Boileau, Jennifer Swindlehurst-Chan, Bryan Marsh, Jacob W. Freimer, Adam Abate, Robert Blelloch
Summary: This study reveals the cell cycle structure of pluripotent embryonic stem cells and the relationship between G1/S restriction point, gene expression, and cellular differentiation. By genetically manipulating G1/S restriction point regulators miR-302 and P27, the researchers found that they can accelerate or delay the onset of phasic gene expression in mouse embryos. Additionally, loss of miR-302-mediated p21 or p27 suppression expedites embryonic stem cell differentiation, while a mutated Cyclin E blocks it. These findings provide new insights into our understanding of cellular differentiation.
NATURE COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Qunli Xiong, Zhiwei Zhang, Yang Yang, Yongfeng Xu, Ying Zhou, Su Zhang, Jinlu Liu, Ying Zheng, Qing Zhu
Summary: This study investigates the role of KLF6 in pancreatic cancer (PAAD). The results show that KLF6 is downregulated in pancreatic cancer tissues and is associated with poor survival. Overexpression of KLF6 inhibits proliferation, metastasis, and epithelial-mesenchymal transition (EMT) in pancreatic cancer cells. It is discovered that KLF6 upregulates activating transcription factor 3 (ATF3) in PAAD.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Jun-Yuan Zhang, Shuang Ma, Xiaoli Liu, Yayun Du, Xilin Zhu, Ying Liu, Xiaopan Wu
Summary: The study reveals that ATF6 positively regulates CTH expression, leading to the generation of H2S and upregulation of autophagy-related proteins, which are closely related to rescuing AD symptoms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Oncology
Yu Zhang, Heming Wu, Honghui Luo, Yiqun Luo, Cong Huang
Summary: This study reveals that ATF3 inhibits fibrosis and viability of cardiac fibroblasts by activating the transcription of Cyr61 in stress overload-induced hearts. This finding enhances our understanding of the role of ATF3 in the development of cardiac diseases and provides a new target for the treatment of heart diseases.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Oncology
Jingyang Chen, Meiru Bian, Lingxiao Pan, Chengdong Liu, Hanshi Yang
Summary: This study analyzed the role of GABPB1-AS1 in osteosarcoma and its underlying mechanism. The results showed that GABPB1-AS1 was highly expressed in osteosarcoma cells and promoted proliferation and migration of these cells through the SP1/Wnt/β-catenin signaling pathway by competitively binding and inhibiting miR-199a-3p.
JOURNAL OF ONCOLOGY
(2022)
Article
Biology
Yifeng Yang, Wenwen Lu, Mei Ning, Xianhao Zhou, Xinyao Wan, Qianglong Mi, Xiaoyan Yang, Di Zhang, Yuanyuan Zhang, Biao Jiang, Lin He, Jia Liu, Yan Zou
Summary: A T/C variant in miR-27a is associated with bipolar disorder by reducing its ability to target important neurodevelopmental genes. This study reveals the relationship between genetic variations of miRNA and schizophrenia or bipolar disorder, emphasizing the importance of miR-27a and its polymorphism in bipolar disorder.
COMMUNICATIONS BIOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Qin Zhou, Shanshan Liu, Yuying Kou, Panpan Yang, Hongrui Liu, Tomoka Hasegawa, Rongjian Su, Guoxiong Zhu, Minqi Li
Summary: In oral cancer tissues and cell lines, P2Y2, Src, and EGFR are highly expressed. Extracellular ATP activates the PI3K/AKT pathway through the P2Y2-Src-EGFR axis, promoting invasion and migration of oral cancer. P2Y2 may be a potential novel target for antimetastasis therapy.
Article
Biotechnology & Applied Microbiology
Tang Xiaoli, Wang Wenting, Zhang Meixiang, Zuo Chunlei, Hu Chengxia
Summary: The high expression of RP11-357H14.17 is closely associated with shortened overall survival and poor prognosis in gastric cancer patients, as well as clinical features such as tumor volume, metastasis, and differentiation. Functional enrichment analysis revealed a close relationship of RP11-357H14.17 with enhanced DNA replication and metabolism, while ssGSEA analysis hinted at its oncogenic roles related to ATF2 signaling and Treg cell differentiation.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Immunology
Tarique Anwar, James Sinnett-Smith, Yi-Ping Jin, Elaine F. Reed, Enrique Rozengurt
Summary: This study examines the impact of statin drugs on YAP activity in human endothelial cells and finds that statins can inhibit YAP activation, providing a possible mechanism for their beneficial effects in solid-organ transplant recipients.
JOURNAL OF IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Madeleine C. Smith, Claire A. Hudson, Tomomi E. Kimura, Stephen J. White, Graciela B. Sala-Newby, Andrew C. Newby, Mark Bond
SCIENTIFIC REPORTS
(2017)
Article
Immunology
Gokce Yildirim-Buharalioglu, Mark Bond, Graciela B. Sala-Newby, Charles C. T. Hindmarch, Andrew C. Newby
FRONTIERS IN IMMUNOLOGY
(2017)
Article
Genetics & Heredity
Gary R. Kunkel, Jessica A. Tracy, Frank L. Jalufka, Arne C. Lekven
Article
Multidisciplinary Sciences
Claire Hudson, Tomomi E. Kimura, Aparna Duggirala, Graciela B. Sala-Newby, Andrew C. Newby, Mark Bond
SCIENTIFIC REPORTS
(2018)
Article
Medicine, Research & Experimental
Alexander Greenhough, Clare Bagley, Kate J. Heesom, David B. Gurevich, David Gay, Mark Bond, Tracey J. Collard, Chris Paraskeva, Paul Martin, Owen J. Sansom, Karim Malik, Ann C. Williams
EMBO MOLECULAR MEDICINE
(2018)
Article
Multidisciplinary Sciences
Jack E. Teasdale, Georgina G. J. Hazell, Alasdair M. G. Peachey, Graciela B. Sala-Newby, Charles C. T. Hindmarch, Tristan R. Mckay, Mark Bond, Andrew C. Newby, Stephen J. White
SCIENTIFIC REPORTS
(2017)
Article
Chemistry, Medicinal
Sarah A. Smith, Richard B. Sessions, Deborah K. Shoemark, Christopher Williams, Reza Ebrahimighaei, Madeleine C. McNeill, Matthew P. Crump, Tristan R. McKay, Gemma Harris, Andrew C. Newby, Mark Bond
JOURNAL OF MEDICINAL CHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Reza Ebrahimighaei, Madeleine C. McNeill, Sarah A. Smith, Jason P. Wray, Kerrie L. Ford, Andrew C. Newby, Mark Bond
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2019)
Review
Cell Biology
Sarah A. Smith, Andrew C. Newby, Mark Bond
Article
Biochemistry & Molecular Biology
Madeleine C. McNeill, Jason Wray, Graciela B. Sala-Newby, Charles C. T. Hindmarch, Sarah A. Smith, Reza Ebrahimighaei, Andrew C. Newby, Mark Bond
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2020)
Article
Cardiac & Cardiovascular Systems
Laura J. Corbin, Stephen J. White, Amy E. Taylor, Christopher M. Williams, Kurt Taylor, Marion T. van den Bosch, Jack E. Teasdale, Matthew Jones, Mark Bond, Matthew T. Harper, Louise Falk, Alix Groom, Georgina G. J. Hazell, Lavinia Paternoster, Marcus R. Munafo, Borge G. Nordestgaard, Anne Tybjaerg-Hansen, Stig E. Bojesen, Caroline Relton, Josine L. Min, George Davey Smith, Andrew D. Mumford, Alastair W. Poole, Nicholas J. Timpson
Summary: Epigenetic DNA hypomethylation at the F2RL3 gene induced by smoking may increase PAR4 expression, leading to downstream effects on platelet reactivity. F2RL3 DNA methylation may be a possible contributory pathway from smoking to cardiovascular disease risk.
CIRCULATION RESEARCH
(2022)
Article
Cell Biology
Joseph W. Hawkins, Madeleine C. McNeill, Reza Ebrahimighaei, Harry H. Mellor, Andrew C. Newby, Mark Bond
Summary: cAMP inhibits NF-kB activity by increasing nuclear actin monomer levels, leading to immunosuppressive and anti-inflammatory effects.
Article
Biochemistry & Molecular Biology
Reza Ebrahimighaei, Graciela B. Sala-Newby, Claire Hudson, Tomomi E. Kimura, Tom Hathway, Joseph Hawkins, Madeleine C. McNeill, Rebecca Richardson, Andrew C. Newby, Mark Bond
Summary: The study reveals a novel mechanism involving YAP-mediated activation of RUNX2 and TEAD in cardiac fibroblast proliferation in response to increased ECM stiffness.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Gary R. Kunkel, Hannah G. Lisciandro, Hannah L. Winter
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2020)
Article
Cell Biology
Laura Huning, Gary R. Kunkel
BMC MOLECULAR AND CELL BIOLOGY
(2020)