Metabolic oxidative stress elicited by the copper(II) complex [Cu(isaepy)2] triggers apoptosis in SH-SY5Y cells through the induction of the AMP-activated protein kinase/p38MAPK/p53 signalling axis: evidence for a combined use with 3-bromopyruvate in neuroblastoma treatment

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(2010) Giuseppe Filomeni et al.   Autophagy

p38MAPK/p53 signalling axis mediates neuronal apoptosis in response to tetrahydrobiopterin-induced oxidative stress and glucose uptake inhibition: implication for neurodegeneration

(2010) Simone Cardaci et al.   BIOCHEMICAL JOURNAL

3-Bromopyruvate: A New Targeted Antiglycolytic Agent and a Promise for Cancer Therapy

(2010) S. Ganapathy-Kanniappan et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Role of mitochondria-associated hexokinase II in cancer cell death induced by 3-bromopyruvate

(2009) Zhao Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

The isatin-Schiff base copper(II) complex Cu(isaepy) 2 acts as delocalized lipophilic cation, yields widespread mitochondrial oxidative damage and induces AMP-activated protein kinase-dependent apoptosis

(2009) Giuseppe Filomeni et al.   CARCINOGENESIS

Loss of Wip1 Sensitizes Cells to Stress- and DNA Damage-induced Apoptosis

(2009) Yun Xia et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cytotoxicity,radiosensitization, and chemosensitization of tumor cells by 2-deoxy-D-glucoseIn vitro

(2009) BS Dwarakanath   Journal of Cancer Research and Therapeutics

The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

(2009) Angel Herrero-Mendez et al.   NATURE CELL BIOLOGY

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Cancer therapy: staying current with AMPK: Figure 1

(2008) David A. Fruman et al.   BIOCHEMICAL JOURNAL

Important role of the LKB1–AMPK pathway in suppressing tumorigenesis in PTEN-deficient mice

(2008) Xu Huang et al.   BIOCHEMICAL JOURNAL

Inhibition of energy-producing pathways of HepG2 cells by 3-bromopyruvate1

(2008) Ana Paula Pereira Da Silva et al.   BIOCHEMICAL JOURNAL

Tumor Cell Metabolism: Cancer's Achilles' Heel

(2008) Guido Kroemer et al.   CANCER CELL

Phosphatidylinositol Ether Lipid Analogues Induce AMP-Activated Protein Kinase Dependent Death in LKB1-Mutant Non Small Cell Lung Cancer Cells

(2008) R. M. Memmott et al.   CANCER RESEARCH

Role of reactive oxygen species-mediated mitochondrial dysregulation in 3-bromopyruvate induced cell death in hepatoma cells

(2008) Ji Su Kim et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Retinoic Acid Leads to Cytoskeletal Rearrangement through AMPK-Rac1 and Stimulates Glucose Uptake through AMPK-p38 MAPK in Skeletal Muscle Cells

(2008) Yun Mi Lee et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Contributes to UV- and H2O2-induced Apoptosis in Human Skin Keratinocytes

(2008) Cong Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From delocalized lipophilic cations to hypoxia: Blocking tumor cell mitochondrial function leads to therapeutic gain with glycolytic inhibitors

(2008) Metin Kurtoglu et al.   MOLECULAR NUTRITION & FOOD RESEARCH

The antidiabetic drug metformin exerts an antitumoral effect in vitro and in vivo through a decrease of cyclin D1 level

(2008) I Ben Sahra et al.   ONCOGENE

Hexokinase-2 bound to mitochondria: Cancer's stygian link to the “Warburg effect” and a pivotal target for effective therapy

(2008) Saroj P. Mathupala et al.   SEMINARS IN CANCER BIOLOGY