Polyamine homoeostasis as a drug target in pathogenic protozoa: peculiarities and possibilities

Design, synthesis and antimalarial/anticancer evaluation of spermidine linked artemisinin conjugates designed to exploit polyamine transporters in Plasmodium falciparum and HL-60 cancer cell lines

(2010) James Chadwick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels

(2010) John VW Becker et al.   BMC GENOMICS

Discovery of Potent and Selective Inhibitors ofTrypanosoma bruceiOrnithine Decarboxylase

(2010) David C. Smithson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redox Regulation of Plasmodium falciparum Ornithine δ-Aminotransferase

(2010) Esther Jortzik et al.   JOURNAL OF MOLECULAR BIOLOGY

Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates

(2010) Susan Wyllie et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Oral putrescine restores virulence of ornithine decarboxylase-deficient Leishmania donovani in mice

(2010) Tamara Olenyik et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

A high-affinity putrescine-cadaverine transporter fromTrypanosoma cruzi

(2010) Marie-Pierre Hasne et al.   MOLECULAR MICROBIOLOGY

Functional consequences of perturbing polyamine metabolism in the malaria parasite, Plasmodium falciparum

(2009) K. Clark et al.   AMINO ACIDS

Structural biology of S-adenosylmethionine decarboxylase

(2009) Shridhar Bale et al.   AMINO ACIDS

The polyamine transport system as a target for anticancer drug development

(2009) Andrew J. Palmer et al.   AMINO ACIDS

Novel S-Adenosylmethionine Decarboxylase Inhibitors for the Treatment of Human African Trypanosomiasis

(2009) R. H. Barker et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Polyamine catabolism and disease

(2009) Robert A. Casero et al.   BIOCHEMICAL JOURNAL

A putrescine–anthracene conjugate: a paradigm for selective drug delivery

(2009) Andrew J. Palmer et al.   BIOCHEMICAL JOURNAL

Leishmaniasis: Current Treatment and Prospects for New Drugs and Vaccines

(2009) Lukasz Kedzierski et al.   CURRENT MEDICINAL CHEMISTRY

S-Adenosylmethionine decarboxylase

(2009) Anthony E. Pegg   Essays in Biochemistry

The polyamines: past, present and future

(2009) Heather M. Wallace   Essays in Biochemistry

RNA Interference-Mediated Silencing of Ornithine Decarboxylase and Spermidine Synthase Genes inTrypanosoma bruceiProvides Insight into Regulation of Polyamine Biosynthesis

(2009) Yanjing Xiao et al.   EUKARYOTIC CELL

Mammalian polyamine metabolism and function

(2009) Anthony E. Pegg   IUBMB LIFE

Chemical Validation of Trypanothione Synthetase

(2009) Leah S. Torrie et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recent Advances in the Development of Polyamine Analogues as Antitumor Agents§

(2009) Robert A. Casero et al.   JOURNAL OF MEDICINAL CHEMISTRY

Nifurtimox-eflornithine combination therapy for second-stage African Trypanosoma brucei gambiense trypanosomiasis: a multicentre, randomised, phase III, non-inferiority trial

(2009) Gerardo Priotto et al.   LANCET

Swedish traveller with Plasmodium knowlesi malaria after visiting Malaysian Borneo: a case report

(2009) Ulf Bronner et al.   MALARIA JOURNAL

Cross-species activation of trypanosome S-adenosylmethionine decarboxylase by the regulatory subunit prozyme

(2009) Erin K. Willert et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi

(2009) Deuan C. Jones et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Dissecting the essentiality of the bifunctional trypanothione synthetase-amidase inTrypanosoma bruceiusing chemical and genetic methods

(2009) Susan Wyllie et al.   MOLECULAR MICROBIOLOGY

Validation of spermidine synthase as a drug target in African trypanosomes

(2008) Martin C. Taylor et al.   BIOCHEMICAL JOURNAL

Structural Basis for Putrescine Activation of HumanS-Adenosylmethionine Decarboxylase†‡

(2008) Shridhar Bale et al.   BIOCHEMISTRY

Redox control in trypanosomatids, parasitic protozoa with trypanothione-based thiol metabolism

(2008) R. Luise Krauth-Siegel et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Predicting druggable binding sites at the protein–protein interface

(2008) Jonathan C. Fuller et al.   DRUG DISCOVERY TODAY

Leishmania donovani Ornithine Decarboxylase Is Indispensable for Parasite Survival in the Mammalian Host

(2008) J. M. Boitz et al.   INFECTION AND IMMUNITY

Crystal Structure of Human Spermine Synthase

(2008) Hong Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LeishmaniaTrypanothione Synthetase-Amidase Structure Reveals a Basis for Regulation of Conflicting Synthetic and Hydrolytic Activities

(2008) Paul K. Fyfe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Co-inhibition ofPlasmodium falciparum S-Adenosylmethionine Decarboxylase/Ornithine Decarboxylase Reveals Perturbation-specific Compensatory Mechanisms by Transcriptome, Proteome, and Metabolome Analyses

(2008) Anna C. van Brummelen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Kinetoplastids: related protozoan pathogens, different diseases

(2008) Ken Stuart et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Plasmodium falciparum Spermidine Synthase Active Site Binders through Structure-Based Virtual Screening

(2008) Micael Jacobsson et al.   JOURNAL OF MEDICINAL CHEMISTRY

The putrescine analogue 1,4-diamino-2-butanone affects polyamine synthesis, transport, ultrastructure and intracellular survival in Leishmania amazonensis

(2008) M. A. Vannier-Santos et al.   MICROBIOLOGY-SGM

Assessing the polyamine metabolism of Plasmodium falciparum as chemotherapeutic target

(2008) Ingrid B. Müller et al.   MOLECULAR AND BIOCHEMICAL PARASITOLOGY

Metabolite profiling of the intraerythrocytic malaria parasitePlasmodium falciparumby1H NMR spectroscopy

(2008) Rongwei Teng et al.   NMR IN BIOMEDICINE

Eliminating Human African Trypanosomiasis: Where Do We Stand and What Comes Next?

(2008) Pere P Simarro et al.   PLOS MEDICINE

Regulated Expression of an Essential Allosteric Activator of Polyamine Biosynthesis in African Trypanosomes

(2008) Erin K. Willert et al.   PLoS Pathogens

Transcriptional responses of Plasmodium falciparum to α-difluoromethylornithine-induced polyamine depletion

(2007) Katherine Clark et al.   BIOLOGICAL CHEMISTRY