Pathogen recognition in the innate immune response

Cutting Edge: Cooperation of IPS-1- and TRIF-Dependent Pathways in Poly IC-Enhanced Antibody Production and Cytotoxic T Cell Responses

(2014) H. Kumar et al.   JOURNAL OF IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC

(2009) Veit Hornung et al.   NATURE

An orthogonal proteomic-genomic screen identifies AIM2 as a cytoplasmic DNA sensor for the inflammasome

(2009) Tilmann Bürckstümmer et al.   NATURE IMMUNOLOGY

HIN-200 Proteins Regulate Caspase Activation in Response to Foreign Cytoplasmic DNA

(2009) T. L. Roberts et al.   SCIENCE

Intracellular pattern-recognition receptors☆

(2008) C DOSTERT et al.   ADVANCED DRUG DELIVERY REVIEWS

Cytoplasmic recognition of RNA☆

(2008) M YONEYAMA et al.   ADVANCED DRUG DELIVERY REVIEWS

NOD-Like Receptors: Role in Innate Immunity and Inflammatory Disease

(2008) Grace Chen et al.   Annual Review of Pathology-Mechanisms of Disease

Cathepsins are required for Toll-like receptor 9 responses

(2008) Fumi Matsumoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Host Innate Immune Receptors and Beyond: Making Sense of Microbial Infections

(2008) Ken J. Ishii et al.   Cell Host & Microbe

Novel primary immunodeficiencies revealed by the investigation of paediatric infectious diseases

(2008) Jacinta Bustamante et al.   CURRENT OPINION IN IMMUNOLOGY

NOD-like receptors (NLRs): bona fide intracellular microbial sensors

(2008) Michael H Shaw et al.   CURRENT OPINION IN IMMUNOLOGY

NLR, the nucleotide-binding domain leucine-rich repeat containing gene family

(2008) Zhengmao Ye et al.   CURRENT OPINION IN IMMUNOLOGY

MDA5/RIG-I and virus recognition

(2008) Osamu Takeuchi et al.   CURRENT OPINION IN IMMUNOLOGY

LPS/TLR4 signal transduction pathway

(2008) Yong-Chen Lu et al.   CYTOKINE

The Nlrp3 inflammasome is critical for aluminium hydroxide-mediated IL-1β secretion but dispensable for adjuvant activity

(2008) Luigi Franchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Structural Mechanism of RNA Recognition by the RIG-I-like Receptors

(2008) Mitsutoshi Yoneyama et al.   IMMUNITY

TRADD Protein Is an Essential Component of the RIG-like Helicase Antiviral Pathway

(2008) Marie-Cécile Michallet et al.   IMMUNITY

Structures of the Toll-like Receptor Family and Its Ligand Complexes

(2008) Mi Sun Jin et al.   IMMUNITY

The Adaptor Protein MITA Links Virus-Sensing Receptors to IRF3 Transcription Factor Activation

(2008) Bo Zhong et al.   IMMUNITY

TLR2 – promiscuous or specific? A critical re-evaluation of a receptor expressing apparent broad specificity

(2008) Ulrich Zähringer et al.   IMMUNOBIOLOGY

The Cytosolic Pattern Recognition Receptor NOD1 Induces Inflammatory Interleukin-8 during Chlamydia trachomatis Infection

(2008) K. R. Buchholz et al.   INFECTION AND IMMUNITY

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid–inducible gene-I and melanoma differentiation–associated gene 5

(2008) Hiroki Kato et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Toll-Like Receptor 3 Has a Protective Role against West Nile Virus Infection

(2008) S. Daffis et al.   JOURNAL OF VIROLOGY

The C-Terminal Regulatory Domain Is the RNA 5′-Triphosphate Sensor of RIG-I

(2008) Sheng Cui et al.   MOLECULAR CELL

Nonself RNA-Sensing Mechanism of RIG-I Helicase and Activation of Antiviral Immune Responses

(2008) Kiyohiro Takahasi et al.   MOLECULAR CELL

TANK-binding kinase-1 delineates innate and adaptive immune responses to DNA vaccines

(2008) Ken J. Ishii et al.   NATURE

Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA

(2008) Takeshi Saito et al.   NATURE

NLRX1 is a regulator of mitochondrial antiviral immunity

(2008) Chris B. Moore et al.   NATURE

UNC93B1 delivers nucleotide-sensing toll-like receptors to endolysosomes

(2008) You-Me Kim et al.   NATURE

The ectodomain of Toll-like receptor 9 is cleaved to generate a functional receptor

(2008) Sarah E. Ewald et al.   NATURE

Crucial role for the Nalp3 inflammasome in the immunostimulatory properties of aluminium adjuvants

(2008) Stephanie C. Eisenbarth et al.   NATURE

Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production

(2008) Tatsuya Saitoh et al.   NATURE

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Regulation of humoral and cellular gut immunity by lamina propria dendritic cells expressing Toll-like receptor 5

(2008) Satoshi Uematsu et al.   NATURE IMMUNOLOGY

Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin

(2008) Karla L Lightfield et al.   NATURE IMMUNOLOGY

Toll-like receptor–mediated induction of type I interferon in plasmacytoid dendritic cells requires the rapamycin-sensitive PI(3)K-mTOR-p70S6K pathway

(2008) Weiping Cao et al.   NATURE IMMUNOLOGY

Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

(2008) Veit Hornung et al.   NATURE IMMUNOLOGY

The DExD/H-box helicase Dicer-2 mediates the induction of antiviral activity in drosophila

(2008) Safia Deddouche et al.   NATURE IMMUNOLOGY

Sequential control of Toll-like receptor–dependent responses by IRAK1 and IRAK2

(2008) Tatsukata Kawagoe et al.   NATURE IMMUNOLOGY

Proteolytic cleavage in an endolysosomal compartment is required for activation of Toll-like receptor 9

(2008) Boyoun Park et al.   NATURE IMMUNOLOGY

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A NOD2-NALP1 complex mediates caspase-1-dependent IL-1  secretion in response to Bacillus anthracis infection and muramyl dipeptide

(2008) L.-C. Hsu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pseudomonas aeruginosa activates caspase 1 through Ipaf

(2008) E. A. Miao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MAVS and MyD88 are essential for innate immunity but not cytotoxic T lymphocyte response against respiratory syncytial virus

(2008) V. G. Bhoj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pyogenic Bacterial Infections in Humans with MyD88 Deficiency

(2008) H. von Bernuth et al.   SCIENCE

Structural Basis of Toll-Like Receptor 3 Signaling with Double-Stranded RNA

(2008) L. Liu et al.   SCIENCE

Cathepsin K-Dependent Toll-Like Receptor 9 Signaling Revealed in Experimental Arthritis

(2008) M. Asagiri et al.   SCIENCE

Innate Immune Activation Through Nalp3 Inflammasome Sensing of Asbestos and Silica

(2008) C. Dostert et al.   SCIENCE

Are the IKKs and IKK-related kinases TBK1 and IKK-ɛ similarly activated?

(2008) Tieu-Lan Chau et al.   TRENDS IN BIOCHEMICAL SCIENCES

The role of viral nucleic acid recognition in dendritic cells for innate and adaptive antiviral immunity

(2007) Katharina Eisenächer et al.   IMMUNOBIOLOGY