Article
Clinical Neurology
Tania Rizo, Lisa Gebhardt, Julia Riedlberger, Esther Eberhardt, Lars Fester, Dalia Alansary, Jurgen Winkler, Soeren Turan, Philipp Arnold, Barbara A. Niemeyer, Michael J. M. Fischer, Beate Winner
Summary: The study demonstrates that pathogenic variants in the SPAST gene lead to dysregulation of spastin, affecting the dynamics of the endoplasmic reticulum and resulting in aberrant calcium regulation.
Article
Biochemistry & Molecular Biology
Joana Poejo, Yolanda Orantos-Aguilera, Francisco Javier Martin-Romero, Ana Maria Mata, Carlos Gutierrez-Merino
Summary: Dysregulation in calcium signaling pathways plays a major role in the initiation of Alzheimer's disease. This study reveals the complexation of Aβ with CaM-binding protein STIM1, leading to the dysregulation of Ca2+ signaling and enhanced amyloidogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cell Biology
Inbal Dagan, Raz Palty
Summary: Calcium signaling in cells plays a crucial role in regulating cell survival, proliferation, and death. Store-operated Ca2+ entry through CRAC channels is a major pathway for Ca2+ influx in non-excitable cells, regulated by a negative feedback mechanism called slow Ca2+ dependent inactivation (SCDI).
Article
Pharmacology & Pharmacy
Xiaoman Yuan, Bin Tang, Yilan Chen, Lijuan Zhou, Jingwen Deng, Lin Han, Yonggong Zhai, Yandong Zhou, Donald L. Gill, Chuanjian Lu, Youjun Wang
Summary: Celastrol, a natural compound, is identified as a novel SOCE inhibitor. It ameliorates skin lesions and reduces PASI scores in psoriasis-like mice by inhibiting Ca2+ entry through its actions on STIM1 and Orai1. These findings suggest that the SOCE pathway may serve as a new druggable target for treating psoriasis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Neurosciences
Alexandre Bouron
Summary: The endoplasmic reticulum (ER) is the primary storage compartment for calcium (Ca2+) in eukaryotic cells. Ca2+ is mobilized from the ER through store-operated Ca2+ channels (SOCCs), leading to a store-operated Ca2+ entry (SOCE) that has been extensively studied in non-excitable cells. The presence of this Ca2+ entry route in neurons has been a subject of debate, but experimental evidence suggests that SOCE can be generated by the recruitment of Ca2+ from neuronal ER Ca2+ stores. This review summarizes the main supporting studies and explores the molecular composition, expression, pharmacological properties, and physiological relevance of neuronal SOCCs.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Neurosciences
Pragnya Chakraborty, Gaiti Hasan
Summary: Key components of endoplasmic reticulum (ER) Ca2+ release and store-operated Ca2+ entry (SOCE) are expressed in all metazoan cells. This review presents evidence on how these two mechanisms impact neuronal physiology and their interaction with ion channels in neurons. The careful regulation of neural SOCE is essential due to the detrimental effects of Ca2+ imbalance on neurons. The study also discusses different mechanisms of SOCE regulation in Drosophila and mammalian neurons, and their significance in human neurodegenerative diseases.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Chemistry, Medicinal
Yu-Shiuan Wang, Teng-Kuang Yeh, Wei-Chiao Chang, Jing-Ping Liou, Yi-Min Liu, Wan-Chen Huang
Summary: Ca2+ entry from store-operated Ca2+ channel (SOC) is involved in regulating colorectal cancer progression. In this study, compound 2,6-Difluoro-N-(5-(4-fluorophenyl)pyridine-2-yl)benzamide (MPT0M004, 8a) demonstrated prominent inhibitory ability on SOC and lower cytotoxicity compared to 2-APB. It has the potential to be developed into a drug for treating colorectal cancer.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Biochemistry & Molecular Biology
Kazuhiko Kawata, Akemi Baba, Masayuki Shiota, Hideki Wanibuchi, Yoshihiro Baba
Summary: Store-operated calcium entry (SOCE) is a major pathway for Ca2+ influx in nonexcitable cells, with STIM1 and EMC1 playing important roles in its regulation. The interaction between STIM1 and EMC1 within the ER is crucial for initiating SOCE, with EMC1 functioning as a positive regulator of this process.
JOURNAL OF BIOCHEMISTRY
(2021)
Article
Genetics & Heredity
Xuexue Zhu, Ke Ma, Kuo Zhou, Jibin Liu, Bernd Nuernberg, Florian Lang
Summary: The study showed that vasopressin enhances the expression of ORAI1 and STIM1, promoting Ca2+entry and osteogenic signaling. The effects of vasopressin-induced Ca2+ entry and osteogenic signaling can be disrupted by MRS1845 and GSK-650394.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Neurosciences
Fang Yu, Raphael Courjaret, Asha Elmi, Ethel Alcantara Adap, Nelson N. Orie, Fawzi Zghyer, Satanay Hubrack, Sajad Hayat, Nidal Asaad, Stefan Worgall, Manikkam Suthanthiran, Vidya Mohamed Ali, Khaled Machaca
Summary: Loss of function mutations in store-operated Ca2+ entry (SOCE) are associated with severe pediatric disorders. It is unclear whether chronic SOCE inhibition is viable therapeutically. Using a genetic mouse model, researchers found that chronic SOCE inhibition is viable therapeutically, but can lead to cardiovascular complications.
JOURNAL OF PHYSIOLOGY-LONDON
(2022)
Review
Cell Biology
Ayat S. Hammad, Khaled Machaca
Summary: Ca2+ signaling is crucial for cell migration, with a focus on the diverse functions of SOCE pathway. While SOCE has been implicated in regulating focal adhesion turnover, its role in other aspects of cell migration remains less well-defined and requires further research.
Article
Oncology
Jose Sanchez-Collado, Joel Nieto-Felipe, Isaac Jardin, Rajesh Bhardwaj, Alejandro Berna-Erro, Gines M. Salido, Tarik Smani, Matthias A. Hediger, Jose J. Lopez, Juan A. Rosado
Summary: Breast cancer cells exhibit altered expression and post-translational modification of STIM proteins and Orai channels, resulting in differences in store-operated Ca2+ entry (SOCE) compared to non-tumoral breast epithelial cells. This study showed that N-linked glycosylation of Orai1 and STIM1 is not essential for SOCE in breast cancer cells and may contribute to apoptosis resistance. Additionally, impairment of STIM1 N-linked glycosylation attenuated caspase-3 activation in non-tumoral cells, while breast cancer cells displayed smaller caspase-3 activity and were unaffected by the non-glycosylable STIM1 mutant. Abnormal SOCE and alterations in glycosylation are associated with cancer development and invasion.
Article
Biochemistry & Molecular Biology
Yang Ye, Xue Li, Zhihua Wang, Fen Ye, Wenrong Xu, Rongzhu Lu, Haijun Shen, Shuhan Miao
Summary: The natural compound 3,3'-Diindolylmethane (DIM) inhibits proliferation and induces apoptosis and autophagy in gastric cancer cells by activating the STIM1-mediated Store-operated calcium entry (SOCE) pathway. Inhibition of SOCE attenuates DIM-induced effects on apoptosis and autophagy, suggesting SOCE as a potential therapeutic target in gastric cancer. Further research is warranted to explore combination chemotherapy strategies targeting SOCE for clinical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Genetics & Heredity
Yang Xue, Shendong Zhou, Wan Xie, Meijuan Meng, Nana Ma, Hongzhu Zhang, Yan Wang, Guangjun Chang, Xiangzhen Shen
Summary: By regulating the expression of STIM1 and Orai1, the effect of LPS-induced inflammation and ERS in bovine hepatocytes can be enhanced, indicating that STIM1/Orai1 can intervene and exacerbate inflammation and ERS in hepatocytes through SOCE.
Review
Cell Biology
Isaac Jardin, Jose J. Lopez, Jose Sanchez-Collado, Luis J. Gomez, Gines M. Salido, Juan A. Rosado
Summary: Cancer stem cells exhibit stemness features and their behavior is influenced by Ca2+ homeostasis and store-operated Ca2+ entry. Understanding the key components of store-operated Ca2+ entry is important for the understanding of cancer stem cell biology and tumorigenesis.
Article
Anesthesiology
Luke Grundy, Cindy Tay, Stewart Christie, Andrea M. M. Harrington, Joel Castro, Fernanda C. C. Cardoso, Richard J. J. Lewis, Vladimir Zagorodnyuk, Stuart M. M. Brierley
Summary: The bladder wall is innervated by a complex network of afferent nerves that detect bladder stretch during filling. Low-voltage-activated T-type calcium channels play a major role in regulating bladder afferent responses to distension.
Editorial Material
Medicine, General & Internal
Zachary Munn, Danielle Pollock, Timothy Hugh Barker, Jennifer Stone, Cindy Stern, Edoardo Aromataris, Holger J. Schuenemann, Barbara Clyne, Hanan Khalil, Reem A. Mustafa, Christina Godfrey, Andrew Booth, Andrea C. Tricco, Alan Pearson
BMJ EVIDENCE-BASED MEDICINE
(2023)
Editorial Material
Medicine, General & Internal
Zachary Munn, Danielle Pollock, Timothy Hugh Barker, Jennifer Stone, Cindy Stern, Edoardo Aromataris, Alan Pearson, Sharon Straus, Hanan Khalil, Reem A. Mustafa, Andrea C. Tricco, Holger J. Schuenemann
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Mathematical & Computational Biology
Timothy H. Barker, Danielle Pollock, Jennifer C. Stone, Miloslav Klugar, Anna M. Scott, Cindy Stern, Rick Wiechula, Larissa Shamseer, Edoardo Aromataris, Amanda Ross-White, Zachary Munn
Summary: Synthesizers of evidence may encounter studies from predatory journals during the evidence synthesis process. This study explores the attitudes and opinions of evidence synthesis experts towards predatory journals. A survey found that most experts agreed with the definition of predatory journals but had hesitations about including studies from these journals in evidence synthesis projects.
RESEARCH SYNTHESIS METHODS
(2023)
Article
Health Care Sciences & Services
Timothy Hugh Barker, Jennifer C. Stone, Kim Sears, Miloslav Klugar, Jo Leonardi-Bee, Catalin Tufanaru, Edoardo Aromataris, Zachary Munn
Summary: JBI provides critical appraisal instruments for systematic reviewers and researchers to investigate methodological limitations in primary research studies. These study-specific instruments are presented as checklist-style questions. However, many of the tools offered by JBI have become outdated as the field of research synthesis expands, necessitating updates.
JBI EVIDENCE SYNTHESIS
(2023)
Editorial Material
Health Care Sciences & Services
Edoardo Aromataris, Mara Lambert
JBI EVIDENCE SYNTHESIS
(2023)
Article
Health Care Sciences & Services
Timothy Hugh Barker, Jennifer C. Stone, Kim Sears, Miloslav Klugar, Catalin Tufanaru, Jo Leonardi-Bee, Edoardo Aromataris, Zachary Munn
Summary: JBI has started updating and revising its critical appraisal tools to align with recent developments in risk of bias science. This paper presents the revised critical appraisal tool for assessing risk of bias in randomized controlled trials, along with guidance on interpretation and application by systematic reviewers. It also discusses the major changes and their justification for facilitating best-practice methodologies.
JBI EVIDENCE SYNTHESIS
(2023)
Review
Health Care Sciences & Services
Zachary Munn, Jennifer C. Stone, Edoardo Aromataris, Miloslav Klugar, Kim Sears, Jo Leonardi-Bee, Timothy Hugh Barker
Summary: A key step in the systematic review process is to assess the methodological quality of included studies. JBI has developed tools to assist with this evaluation. This paper introduces their vision for risk of bias assessment and future papers will discuss the revision process and guidance for using the tools.
JBI EVIDENCE SYNTHESIS
(2023)
Article
Biochemistry & Molecular Biology
Joel Castro, Jessica Maddern, Chun Yuen Chow, Poanna Tran, Irina Vetter, Glenn F. King, Stuart M. Brierley
Summary: In this study, the role of sodium channel Na(V)1.7 in endometriosis-induced chronic pelvic pain was examined. Selective inhibition of this channel can alleviate pain without affecting normal sensation. This research provides a new possibility for improving the quality of life for women with endometriosis.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Multidisciplinary Sciences
James R. R. Bayrer, Joel Castro, Archana Venkataraman, Kouki K. K. Touhara, Nathan D. D. Rossen, Ryan D. D. Morrie, Jessica Maddern, Aenea Hendry, Kristina N. N. Braverman, Sonia Garcia-Caraballo, Gudrun Schober, Mariana Brizuela, Fernanda M. M. Castro Navarro, Carla Bueno-Silva, Holly A. A. Ingraham, Stuart M. M. Brierley, David Julius
Summary: Gastrointestinal discomfort is a common symptom of gut disorders and chronic visceral pain, especially in patients with irritable bowel syndrome. Enterochromaffin (EC) cells, which are rare serotonergic neuroendocrine cells in the gut epithelium, play a crucial role in detecting and transmitting noxious stimuli to nerve endings. The activation and dysfunction of EC cells are associated with hypersensitivity to gut distension and the inflammatory effects of certain fatty acids. Additionally, prolonged EC cell activation leads to persistent visceral hypersensitivity and anxiety-like behaviors. Furthermore, there are notable sex differences in the involvement of the EC cell-mucosal afferent circuit.
Review
Health Care Sciences & Services
Jennifer C. Stone, Timothy Hugh Barker, Edoardo Aromataris, Merel Ritskes-Hoitinga, Kim Sears, Miloslav Klugar, Jo Leonardi-Bee, Zachary Munn
Summary: The critical appraisal of literature has advanced through epidemiologic research methods and evidence-based medicine, where scientific support is used to guide medical teaching and practice. As evidence synthesis methodology has developed, terms such as risk of bias, critical appraisal, and study validity have been used to differentiate the assessment of primary research from synthesized research. This paper discusses the definitions and characteristics of these terms, recommending the adoption of the term risk of bias assessment by JBI.
JBI EVIDENCE SYNTHESIS
(2023)
Editorial Material
Health Care Sciences & Services
Edoardo Aromataris
JBI EVIDENCE SYNTHESIS
(2023)
Review
Health Care Sciences & Services
Bora Jeong, Giri Krishnan, Andrew Foreman, Edoardo Aromataris
Summary: This systematic review aims to investigate the oncological and functional outcomes of primary transoral surgery compared with non-surgical management in patients with small-volume oropharyngeal cancer. Various study designs will be included, and data will be pooled for meta-analysis. The review is registered with PROSPERO CRD4202235209.
JBI EVIDENCE SYNTHESIS
(2023)
Review
Health Care Sciences & Services
Zachary Munn, Danielle Pollock, Carrie Price, Edoardo Aromataris, Cindy Stern, Jennifer C. Stone, Timothy Hugh Barker, Christina M. Godfrey, Barbara Clyne, Andrew Booth, Andrea C. Tricco, Zoe Jordan
Summary: This scoping review aims to identify evidence synthesis types and previously proposed classification systems, typologies, or taxonomies. It will explore the development and characteristics of these systems and provide an overview of the types of evidence syntheses they include.
JBI EVIDENCE SYNTHESIS
(2023)
Article
Mathematical & Computational Biology
Danielle Pollock, Timothy Hugh Barker, Jennifer C. Stone, Edoardo Aromataris, Miloslav Klugar, Anna M. Scott, Cindy Stern, Amanda Ross-White, Ashley Whitehorn, Rick Wiechula, Larissa Shamseer, Zachary Munn
Summary: Predatory journals, which publish studies with a higher likelihood of containing false data, are a blemish on scholarly publishing and academia. This paper explores the opinions and attitudes of evidence synthesisers towards predatory journals and the inclusion of studies from these journals in evidence syntheses. The findings suggest that evidence synthesisers struggle to identify predatory journals and there is currently no consensus on how to manage these studies.
RESEARCH SYNTHESIS METHODS
(2023)