期刊
BIOCHEMICAL JOURNAL
卷 423, 期 -, 页码 1-14出版社
PORTLAND PRESS LTD
DOI: 10.1042/BJ20090969
关键词
cholesterol; exocytosis; lipid; liposome; microdomain; soluble N-ethylmaleimide sensitive factor-attachment protein receptor (SNARE)
资金
- Canadian Institutes of Health Research (CIHR)
- Alberta Heritage Foundation for Medical Research (AHFMR)
- Natural Sciences and Engineering Research Council of Canada (NSERC)
- University of Western Sydney
Exocytosis is a highly conserved and essential process. Although numerous proteins are involved throughout the exocytotic process, the defining membrane fusion step appears to occur through a lipid-dominated mechanism. Here we review and integrate the current literature on protein and lipid roles in exocytosis, with emphasis on the multiple roles of cholesterol in exocytosis and membrane fusion, in an effort to promote a more molecular systems-level view of the as yet poorly understood process of Ca2+-triggered membrane mergers.
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