Review
Cell Biology
Clovis H. T. Seumen, Tanja M. Grimm, Christof R. Hauck
Summary: Toll-like receptors (TLRs) play a crucial role in immune response, but exaggerated activation can lead to inflammatory diseases. This review discusses the impact of protein phosphorylation on TLR signaling, highlighting the role of phosphatases as negative regulators. Understanding phosphatase-mediated regulation could offer new approaches to modulate immune signaling.
CELL COMMUNICATION AND SIGNALING
(2021)
Article
Cell Biology
Ya Gao, Boting Xi, Jiani Li, Zimeng Li, Jie Xu, Mingli Zhong, Qiongmei Xu, Yuanyu Lian, Riming Wei, Liping Wang, Houkang Cao, Ling Jin, Kefeng Zhang, Jianghui Dong
Summary: This study demonstrated that scoparone alleviates hepatic fibrosis by inhibiting the TLR-4/NF-κB signaling pathway, with the most significant effect observed at high doses.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Oncology
Sajad Fakhri, Seyed Zachariah Moradi, Akram Yarmohammadi, Fatemeh Narimani, Carly E. Wallace, Anupam Bishayee
Summary: This is the first comprehensive and systematic review on the role of phytochemicals in mitigating chemoresistance by regulating the TLR/NF-kappa B/NLRP signaling pathway in chemotherapy and immunotherapy.
FRONTIERS IN ONCOLOGY
(2022)
Article
Environmental Sciences
John D. Hansen, Keith A. Loftin, Zachary Laughrey, Ondrej Adamovsky
Summary: Various stressors can have profound impacts on immunity to pathogens, with little research into the effects of cyanobacterial toxins on disease resistance in mammals. Recent studies suggest that freshwater cyanotoxins may alter disease susceptibility parameters for fish, wildlife, and human health through interaction with specific components of innate immunity. However, the results of this study indicate that the tested toxins did not directly interact with key pathogen recognition receptors for innate immunity in humans.
Review
Immunology
Marion Mussbacher, Martina Derler, Jose Basilio, Johannes A. Schmid
Summary: Nuclear factor kappa B (NF-kappa B) is a dimeric transcription factor that regulates the expression of chemokines, cytokines, transcription factors, and regulatory proteins, playing a crucial role in inflammation and immunity. Understanding its specific roles in different cell types, tissues, and under different stimuli is important. This review focuses on the role of NF-kappa B in monocytes and macrophages, innate immune cells that exhibit high plasticity and adjust their functions against pathogens and cues from the environment. NF-kappa B activation in macrophages has significant implications in inflammatory diseases and its temporal dynamics are complex.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Medicine, Research & Experimental
Mingkwan Na Takuathung, Saranyapin Potikanond, Siriwoot Sookkhee, Pitchaya Mungkornasawakul, Thanathorn Jearanaikulvanich, Kittinan Chinda, Nitwara Wikan, Wutigri Nimlamool
Summary: The study demonstrated that Kaempferia parviflora extract has significant anti-inflammatory and anti-psoriatic effects by suppressing key inflammatory markers and inhibiting NF-kappa B pathway activation and protein phosphorylation. The results suggest that KP extract has potential as a promising agent for treating inflammation and psoriasis.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Wei Dai, Ping Zheng, Deqiang Luo, Qian Xie, Fen Liu, Qiang Shao, Ning Zhao, Kejian Qian
Summary: This study aimed to identify ferroptosis-related genes in sepsis and provide potential therapeutic targets for translation. Through analysis of gene co-expression networks and differentially expressed genes, LPIN1 was identified as a reliable biomarker for patient survival in sepsis and was associated with immune and inflammation status.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cell Biology
Wenfei Pan, Limei Deng, Haitao Wang, Vivien Ya-Fan Wang
Summary: The NF-kappa B family of dimeric transcription factors regulate various biological functions. A study has revealed that the atypical I kappa B protein, Bcl3, plays a crucial role in enhancing the population of the p52:p52 homodimer within the NF-kappa B family. Bcl3 competes with other NF-kappa B subunits for efficient p52:p52 homodimer formation, leading to the upregulation of target genes involved in cell proliferation, migration, and inflammation. The aberrant activation of Bcl3 and p52 contributes to cancer.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xuye Jiang, Yingying Gu, Yuanling Huang, Yujia Zhou, Nengzhi Pang, Jing Luo, Zhaoyang Tang, Zhenfeng Zhang, Lili Yang
Summary: The study found that CBD can prevent liver steatosis and oxidative stress induced by high-fat high-cholesterol diet, and alleviate inflammation by inhibiting activation of the hepatic NF kappa B-NLRP3 inflammasome-pyroptosis pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Marina Luchner, Soren Reinke, Anita Milicic
Summary: Modern vaccines have shifted towards subunit components, requiring adjuvants to enhance immunogenicity. Toll-like receptor agonists show promise as adjuvants by linking innate and adaptive immune responses and providing danger signals for effective immune responses.
Review
Biochemistry & Molecular Biology
Monika Gudowska-Sawczuk, Barbara Mroczko
Summary: This review paper focuses on the role of Nuclear Factor kappa B (NF-kappa B) in the development of COVID-19 and its potential application in the treatment of SARS-CoV-2 infection. It highlights the important functions of NF-kappa B in modulating the inflammatory response and the increased activation of NF-kappa B in SARS-CoV-2 infection. The modulation of NF-kappa B can result in decreased synthesis of proinflammatory factors caused by SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Multidisciplinary Sciences
Clovis H. T. Seumen, Urte Tomasiunaite, Daniel F. Legler, Christof R. Hauck
Summary: The use of Toll-like receptors (TLRs) in detecting microbial contaminants is a powerful tool, but current methods have been hindered by slow cellular responses and limited sensitivity. A new approach using genetic and pharmacologic methods to enhance cellular responses to bacterial molecular patterns shows promise in replacing animal-based testing for microbial contaminants.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Medicinal
Seokwon Shin, Jayeon Park, Ye Eun Lee, Hanbin Ko, Hyung-Sun Youn
Summary: Toll-like receptors (TLRs) play a crucial role in immune responses by activating signaling pathways that induce inflammation. Research has shown that isobavachalcone (IBC) can inhibit the activation of TLR signaling pathways, opening up new therapeutic options for inflammatory diseases involving TLRs.
ARCHIV DER PHARMAZIE
(2022)
Article
Pharmacology & Pharmacy
Chen Shu, Zhang Yan-Yan, Zhang Hai, Ding Long-Kun, Xi Yue, Yan Man, Sun Chang, Wu Liang, Hu Hao
Summary: This study found that sodium butyrate and sodium propionate can significantly inhibit the inflammation induced by Acinetobacter baumannii in THP-1 cells, with the inhibitory effect being in the order of sodium butyrate > sodium propionate > sodium acetate. These SCFAs may inhibit inflammation through the TLR-2/NF-kappa B/ROS/NLRP3 signaling pathway.
ACTA PHARMACEUTICA
(2022)
Review
Immunology
Yosi Gilad, David M. Lonard, Bert W. O'Malley
Summary: SRCs are essential regulators of transcription with diverse biological functionalities in immunity. The three family members, SRC-1, SRC-2 and SRC-3, can act independently or synergistically, compensating for each other in certain biological contexts and competing against each other in others. The recent development of SRC small molecule inhibitors and stimulators provides potential for modulating immunological activity of SRCs for therapeutic purposes.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Cell Biology
Ching-Wen Chang, Jeng-Fan Lo, Xin Wei Wang
Correction
Oncology
Wan-Chun Li, Chien-Hsiang Huang, Yi-Ta Hsieh, Tsai-Ying Chen, Li-Hao Cheng, Chang-Yi Chen, Chung-Ji Liu, Hsin-Ming Chen, Chien-Ling Huang, Jeng-Fan Lo, Kuo-Wei Chang
FRONTIERS IN ONCOLOGY
(2020)
Article
Oncology
Wei-Chun Hu, Wan-Huai Teo, Tung-Fu Huang, Te-Chang Lee, Jeng-Fan Lo
FRONTIERS IN ONCOLOGY
(2020)
Article
Multidisciplinary Sciences
Wan-Huai Teo, Jeng-Fan Lo, Yu-Ning Fan, Chih-Yang Huang, Tung-Fu Huang
Article
Oncology
Sheng-Fan Wang, Kuo-Hung Huang, Wei-Chuan Tseng, Jeng-Fan Lo, Anna Fen-Yau Li, Wen-Liang Fang, Chian-Feng Chen, Tien-Shun Yeh, Yuh-Lih Chang, Yueh-Ching Chou, Hung-Hsu Hung, Hsin-Chen Lee
Article
Oncology
Kuan-Yang Chen, Yi-Hsiang Huang, Wan-Huai Teo, Ching-Wen Chang, Yu-Syuan Chen, Yi-Chen Yeh, Chieh-Ju Lee, Jeng-Fan Lo
Summary: Tid1 acts as a tumor suppressor in HCC by affecting Nrf2 protein levels and malignancy of HCC cells. Low Tid1 expression and high Nrf2 expression in non-tumor parts are associated with worse recurrence-free survival in multivariate analysis of 210 HCC cases. A scoring system integrating clinical and pathological factors can predict RFS in surgically resected HCC patients.
Review
Immunology
Jongdae Lee, Beatriz Lozano-Ruiz, Fengyuan Mandy Yang, Dengxia Denise Fan, Liya Shen, Jose M. Gonzalez-Navajas
Summary: Immune checkpoint inhibition has become a key aspect of cancer therapy, with CD4(+) T cells playing a crucial role in modulating immune responses against tumors. Different subsets of helper T cells have varying impacts on the clinical response to immune checkpoint therapy.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Jose M. Gonzalez-Navajas, Dengxia Denise Fan, Shuang Yang, Fengyuan Mandy Yang, Beatriz Lozano-Ruiz, Liya Shen, Jongdae Lee
Summary: Cancer arises from genetic mutations allowing cells to proliferate uncontrollably, but the failure of anticancer immunity, influenced by the tumor environment's impact on T cells, is essential for cancer survival. Immune checkpoint inhibitor therapy was developed to combat the immune paralysis induced by tumor environments, specifically by targeting molecules like PD-1. While effector T cells work to eliminate cancers, Tregs in the tumor environment suppress native anticancer immunity and reduce the efficacy of ICI therapies. Targeted efforts to deplete tumor-associated Tregs are underway to enhance ICI therapy effectiveness without causing systemic autoimmune responses. Understanding the roles of Tregs in anti-cancer immunity and ICI therapies can lead to more precise targeting of intratumoral Tregs.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ayaz Ali, Marthandam Asokan Shibu, Chia-Hua Kuo, Jeng-Feng Lo, Ray-Jade Chen, Cecilia Hsuan Day, Tsung-Jung Ho, Vijaya PadmaViswanadha, Wei-Wen Kuo, Chih-Yang Huang
Summary: Studies have shown that under high glucose conditions, CHIP can enhance cell viability by reducing oxidative stress and inhibiting MAPK-induced apoptosis and fibrosis. This suggests that CHIP protects WJMSCs and high-quality WJMSCs have potential therapeutic effects against diabetes-induced kidney injuries.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Cell Biology
Liping Luo, Junyan Zhang, Jongdae Lee, Ailin Tao
Summary: Platelets play a crucial role in allergic asthma by mediating airway inflammation and immune responses via various pathways, contributing to the progression of the disease. Understanding the role of platelets in the pathogenesis of allergic asthma may lead to new insights and novel treatment approaches.
Article
Biotechnology & Applied Microbiology
Ayaz Ali, Wei-Wen Kuo, Chia-Hua Kuo, Jeng-Fan Lo, Michael Y. C. Chen, Jayasimha R. Daddam, Tsung-Jung Ho, Vijaya Padma Viswanadha, Marthandam Asokan Shibu, Chih-Yang Huang
Summary: Recent studies have shown that umbilical cord stem cells provide cytoprotective effects against various disorders, however, their viability may be reduced under stressful conditions such as diabetes. This study identified the molecular mechanisms by which high glucose conditions induce apoptosis and oxidative stress in Wharton's jelly derived mesenchymal stem cells, with a focus on the role of Carboxyl terminus of Hsc70 interacting protein (CHIP) in promoting PTEN degradation and protecting against diabetic effects.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Mei-Chun Chen, Li-Lin Hsu, Sheng-Fan Wang, Yi-Ling Pan, Jeng-Fan Lo, Tien-Shun Yeh, Ling-Ming Tseng, Hsin-Chen Lee
Summary: This study revealed that activation of the integrated stress response (ISR) through salubrinal under glucose deprivation conditions increased cancer cell death by upregulating xCT and inducing mitochondrial oxidative stress.
Article
Cell Biology
Kuan-Ho Lin, Ayaz Ali, Chia-Hua Kuo, Pei-Chen Yang, Velmurugan B. Kumar, Viswanadha V. Padma, Jeng-Fan Lo, Chih-Yang Huang, Wei-Wen Kuo
Summary: Our study demonstrates that CHIP can target NF kappa B for ubiquitin-mediated proteasomal degradation, potentially rescuing AGE-induced cardiac damages.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kuo-Chu Lai, Prabha Regmi, Chung-Ji Liu, Jeng-Fan Lo, Te-Chang Lee
Summary: The study demonstrates that IFIT2 depletion promotes the CSC-like phenotypes in oral cancer cells. Clinically, there is a positive correlation between IFIT2 and CD24 in oral cancer patients, and the expression pattern of IFIT2(high)/CD24(high)/CD44(low) predicts a better prognosis. Furthermore, TNF-alpha blockade can abolish the sphere formation induced by IFIT2 depletion, suggesting its involvement in CSC-like phenotypes in oral cancer.
Article
Biochemistry & Molecular Biology
Kai-Feng Hung, Po-Chen Liao, Chih-Kai Chen, Yueh-Ting Chiu, Dong-Hui Cheng, Masaoki Kawasumi, Shou-Yen Kao, Jeng-Fan Lo
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2019)