Article
Cell Biology
Madison Bolger-Munro, Kate Choi, Faith Cheung, Yi Tian Liu, May Dang-Lawson, Nikola Deretic, Connor Keane, Michael R. Gold
Summary: This study explores the regulation of actin cytoskeleton remodeling and BCR signaling amplification in B cells encountering APC-bound antigens. It highlights the distinct roles of Wdr1, LIMK, cofilin, and Cotl1 in this process.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jia-Yi Wei, Sao-Yu Chu, Yu-Chien Huang, Pei-Chi Chung, Hung-Hsiang Yu
Summary: Neurogenesis in the Drosophila central brain is influenced by a novel mutation called Nuwa, with significant impairment occurring during early larval stages. The mutation affects the generation of larval-born olfactory projection neurons but not embryonic-born neurons. Molecular characterization reveals that the Nuwa mutation is a loss-of-function mutation in the Drosophila septin interacting protein 1 (sip1). SIP1 expression is enriched in neuroblasts, and its knockdown leads to abnormal brain formation. The full-length SIP1 protein is necessary for rescuing the neurogenesis defect caused by the Nuwa mutation.
SCIENTIFIC REPORTS
(2022)
Review
Biochemistry & Molecular Biology
Zhiwei Zhang, Qing Zhu
Summary: WD repeat and HMG-box DNA binding protein 1 (WDHD1) is a highly conserved gene that plays a crucial role in DNA replication, DNA damage repair, cell cycle regulation, centromere formation, and sister chromosome segregation. It has been implicated in the development and progression of various tumor types, and inhibiting WDHD1 shows potential in enhancing radiation sensitivity, improving drug resistance, and decreasing tumor cell proliferation. This comprehensive review provides an overview of WDHD1's molecular structure, biological functions, and regulatory mechanisms in tumors, aiming to establish a foundation for future research and potential clinical applications of WDHD1.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Xiaosong Wei, Beibei Wang, Zixin Wu, Xiaoming Yang, Yufeng Guo, Yang Yang, Zhiwei Fang, Chengzhi Yi, Liuhui Zhang, Xin Fan, Lirong Zhang, Dongkui Song
Summary: The WD40 repeat (WDR) domain is one of the most abundant protein-protein interaction domains in the human proteome. A Gene Expression Omnibus dataset identified 37 differentially expressed WDR domain genes in bladder cancer (BC). Among them, WDR repeat domain 54 (WDR54) was overexpressed in BC cells and its high expression was associated with tumor stage and lymph node metastases in patients. WDR54 contributed to the tumorigenesis and metastasis of BC, impaired its chemosensitivity, and regulated the interaction between MEMO1 and IRS1, activating the IRS1/AKT/beta-catenin pathway in BC cells. This study provides insight into the molecular mechanisms underlying BC and highlights the relevance of WDR54 in this disease.
Review
Cell Biology
Sara Tur-Gracia, Narcisa Martinez-Quiles
Summary: Immune cells heavily rely on the proper functioning of the actin cytoskeleton for various functions like adhesion, migration, and synapse formation. Dysfunctions in the cytoskeleton can compromise immune responses and lead to immune system defects. Recent research has highlighted the importance of actin-cytoskeleton-remodeling proteins in immune pathophysiology, particularly in autoimmune and autoinflammatory conditions.
JOURNAL OF CELL SCIENCE
(2021)
Article
Virology
Mingwei Li, Yang Wu, Jianfei Chen, Hongyan Shi, Zhaoyanag Ji, Xin Zhang, Da Shi, Jianbo Liu, Jin Tian, Xiaobo Wang, Zhaorong Shi, Hongling Zhang, Hao Zhang, Longjun Guo, Li Feng
Summary: This study reveals that PEDV infection can bypass the host innate immune response by targeting and degrading FBXW7 protein, thereby impairing the host's ability to fight back against the virus.
JOURNAL OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sophie Wulf, Luisa Mizko, Karl-Heinz Herrmann, Marta Sanchez-Carbonell, Anja Urbach, Cornelius Lemke, Alexander Berndt, Ivonne Loeffler, Gunter Wolf
Summary: MORG1 is a scaffold molecule for the ERK signaling pathway and also interacts with prolyl-hydroxylase 3, modulating the expression of HIF-1α. Knockout mice lacking Morg1 were generated and showed embryonic lethality due to severe developmental defects, particularly in the brain, spinal cord, and chorioallantoic fusion.
Article
Multidisciplinary Sciences
L. Rodriguez-Fernandez, S. Company, R. Zaragoza, J. R. Vina, E. R. Garcia-Trevijano
Summary: This study reveals the role of CAPN2 during mitosis, uncovers the critical role of CAPN2 in the interactions among nuclear components, identifies LIMK1 as a new target of CAPN2, and provides a novel mechanism for LIMK1 activation. It also highlights the importance of CFL1 in cytoskeleton remodeling, mitosis, nuclear structure maintenance, chromosome movement, and transcription modulation in cancer cells, suggesting that the role of CAPN2 in the nuclear compartment might extend to other actin-associated biological and pathological processes.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Sergey A. Vishnivetskiy, Liana D. Weinstein, Chen Zheng, Eugenia V. Gurevich, Vsevolod V. Gurevich
Summary: Arresin-1 shows selectivity for light-activated phosphorylated rhodopsin, and this selectivity is mediated by two structural elements in the molecule. In the crystal structure, there are some residues close to rhodopsin that do not belong to the selectivity mechanism. Mutations in these residues enhance binding to unphosphorylated rhodopsin and increase its selectivity for phosphorylated rhodopsin. This challenges the current model of arrestin-receptor interactions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Yong Liu, You Wang, Juan Yang, Tao Xu, Changhong Tan, Peng Zhang, Qiankun Liu, Yangmei Chen
Summary: The study identified that GIPC1 is downregulated in patients with epilepsy and mice with induced epilepsy, and it interacts with mGluR7 to regulate epileptogenesis by increasing mGluR7 expression.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Fisheries
Yishuai Li, Yi Gong, Ying Chen, Baozhen Qu, Shicui Zhang
Summary: Cfl1, a newly-characterized antimicrobial protein in zebrafish, binds to bacterial molecules LPS and LTA, inhibits bacterial growth, and plays an important role in immune response by causing bacterial cell destruction and inducing intracellular ROS production.
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY
(2022)
Article
Pathology
Ji-Yun Wu, Xiao-Lu Lan, Dong-Mei Yan, Ye-Ying Fang, Yun-Xi Peng, Fei-Fei Liang, Li Jiang, Su-Ning Huang, Miao Mo, Cai-Xing Lin, Yi-Tong Niu, Xiao-Wei Wu, Zhu-Xin Wei
Summary: This study found that WDHD1 is highly expressed in laryngeal squamous cell carcinoma (LSCC) tissues and has a significant positive correlation with its target gene Skp2. Further analysis suggests that WDHD1 and its target gene may play a critical role in the progression of LSCC by regulating the cell cycle.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Cell Biology
Zhiwen Fan, Ming Kong, Wenhui Dong, Chunlong Dong, Xiulian Miao, Yan Guo, Xingyu Liu, Shuying Miao, Lin Li, Tingting Chen, Yeqing Qu, Fei Yu, Yunfei Duan, Yunjie Lu, Xiaoping Zou
Summary: Infiltration of eosinophils is associated with and contributes to liver regeneration. Eotaxin-1 expression is elevated in proliferating murine livers and can be stimulated by hepatocyte growth factor (HGF). Brg1 is a chromatin remodeling protein that directly binds to the eotaxin promoter to activate its transcription, and interacts with NF-kappa B/RelA to activate eotaxin transcription. Depletion of eotaxin or Brg1 deficiency delays liver regeneration.
CELL DEATH & DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Soma Saeidi, Su-Jung Kim, Yanymee N. Guillen-Quispe, Achanta Sri Venkata Jagadeesh, Hyeong-Jun Han, Seung Hyeon Kim, Xiancai Zhong, Juan-Yu Piao, Seong-Jin Kim, Joon Jeong, Yun Jin Shin, Yoon Jin Cha, Han-Byoel Lee, Wonshik Han, Sang-Hyun Min, Wang Tian, Hiroshi Kitamura, Young-Joon Surh
Summary: Pin1 is frequently overexpressed in various types of malignancy, including triple-negative breast cancer, and plays a role in stabilizing and activating Nrf2 by competing with Keap1 for Nrf2 binding, thus promoting breast cancer progression. Through its interaction with phosphorylated Nrf2 and Keap1 residues, Pin1 alters the stability and function of Nrf2, leading to the accumulation of Nrf2 in the nucleus and contributing to breast cancer development and progression.
Review
Neurosciences
Felix Schneider, Thuy-An Duong, Isabell Metz, Jannik Winkelmeier, Christian A. Hubner, Ulrike Endesfelder, Marco B. Rust
Summary: The study identified CAP1 as a novel actin regulator in growth cones that is crucial for neuron connectivity. Functional interdependence of CAP1 and cofilin1 in neuronal actin dynamics and growth cone function was demonstrated through rescue experiments in double KO neurons.
PROGRESS IN NEUROBIOLOGY
(2021)
Review
Cell Biology
Kazumasa Ohashi
DEVELOPMENT GROWTH & DIFFERENTIATION
(2015)
Article
Cell Biology
Hiyori Abiko, Sachiko Fujiwara, Kazumasa Ohashi, Ryuichi Hiatari, Toshiya Mashiko, Naoya Sakamoto, Masaaki Sato, Kensaku Mizuno
JOURNAL OF CELL SCIENCE
(2015)
Article
Cell Biology
Sachiko Fujiwara, Kazumasa Ohashi, Toshiya Mashiko, Hiroshi Kondo, Kensaku Mizuno
MOLECULAR BIOLOGY OF THE CELL
(2016)
Review
Biochemistry & Molecular Biology
Kazumasa Ohashi, Sachiko Fujiwara, Kensaku Mizuno
JOURNAL OF BIOCHEMISTRY
(2017)
Article
Cell Biology
Ryosuke Nishhnura, Kagayaki Kato, Sachiko Fujiwara, Kazumasa Ohashii, Kensaku Mizuno
CELL STRUCTURE AND FUNCTION
(2018)
Article
Multidisciplinary Sciences
Sachiko Fujiwara, Tsubasa S. Matsui, Kazumasa Ohashi, Shinji Deguchi, Kensaku Mizuno
Article
Biochemistry & Molecular Biology
Yuta Homma, Shin-ichiro Kanno, Kazutaka Sasaki, Michiru Nishita, Akira Yasui, Tomoichiro Asano, Kazumasa Ohashi, Kensaku Mizuno
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Cell Biology
Kazumasa Ohashi, Kaori Sampei, Mami Nakagawa, Naoto Uchiumi, Tatsuya Amanuma, Setsuya Aiba, Masato Oikawa, Kensaku Mizuno
MOLECULAR BIOLOGY OF THE CELL
(2014)
Article
Multidisciplinary Sciences
Ritsuko Morita, Miho Kihira, Yousuke Nakatsu, Yohei Nomoto, Miho Ogawa, Kazumasa Ohashi, Kensaku Mizuno, Tetsuhiko Tachikawa, Yukitaka Ishimoto, Yoshihiro Morishita, Takashi Tsuji
Article
Cell Biology
Sachiko Fujiwara, Tsubasa S. Matsui, Kazumasa Ohashi, Kensaku Mizuno, Shinji Deguchi
Article
Evolutionary Biology
Daiki X. Sato, Yuu Ishii, Tomoaki Nagai, Kazumasa Ohashi, Masakado Kawata
BMC EVOLUTIONARY BIOLOGY
(2019)
Article
Cell Biology
Yusuke Isozaki, Kouki Sakai, Kenta Kohiro, Katsuhiko Kagoshima, Yuma Iwamura, Hironori Sato, Daniel Rindner, Sachiko Fujiwara, Kazunari Yamashita, Kensaku Mizuno, Kazumasa Ohashi
MOLECULAR BIOLOGY OF THE CELL
(2020)
Article
Engineering, Biomedical
Luqman Khan, Katsumi Sato, Shinichi Okuyama, Takeshi Kobayashi, Kazumasa Ohashi, Katsuya Hirasaka, Takeshi Nikawa, Kunio Takada, Atsushi Higashitani, Kenji Abiko
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2020)
Article
Cell Biology
Komaki Ninomiya, Kai Ohta, Kazunari Yamashita, Kensaku Mizuno, Kazumasa Ohashi
Summary: PLEKHG4B plays a crucial role in epithelial cell-cell junction formation by regulating actin remodeling and modulating the activities of Cdc42 and RhoA. Knockdown of PLEKHG4B leads to open junctions and aberrant myosin activity.
JOURNAL OF CELL SCIENCE
(2021)
Meeting Abstract
Pharmacology & Pharmacy
Ichiro Kawahata, Lai Yanxin, Shiori Ohtaku, Junichi Morita, Shigeki Kato, Akiko Tabuchi, Mamoru Fukuchi, Masaaki Tsuda, Kazumasa Ohashi, Kensaku Mizuno, Yasuhiko Izumi, Toshiaki Kume, Akinori Akaike, Yoshihisa Tomioka, Chiho Sumi-Ichinose, Kazunao Kondo, Hiroshi Ichinose, Kazuto Kobayashi, Tohru Yamakuni
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2014)