期刊
BIOCHEMICAL ENGINEERING JOURNAL
卷 69, 期 -, 页码 100-105出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.bej.2012.09.005
关键词
Fermentation; Microbial growth; Product inhibition; Butanol tolerance; Dose response assessment
资金
- Taiwan's National Science Council under NSC [NSC 98-2621-M-006-007, NSC 99-2621-M-006-005, NSC 100-2621-M-197-001, NSC 101-2221-E-197-020]
- NCKU's Top University Grant
This study aimed to quantitatively evaluate the correlations between butanol (BtOH) tolerance of solvent-producing bacteria (SPB) and the performance of fermentative butanol production. The toxicity potency of BtOH was revealed to suggest the feasibility of butanol formation with a Clostridial species-dominated bacterial consortium. When the mixed culture was grown on the optimal medium comprising 60 g/L glucose, 0.5 g/L FeSO4 center dot 7H(2)O and 5.13 g/L yeast extract, the maximal tolerant butanol concentration, butanol production, hydrogen production and glucose consumption were ca. 16 g/L, 10.64 +/- 0.60 g/L, 4153 +/- 815 mL/L and 54.99 +/- 1.92 g/L, respectively. Moreover, almost all the dose-response curves representing toxicity potency of butanol on microbial characteristics was nearly identical in order of magnitude. Thus, although generations of by-products during butanol fermentation are interactive, the maintenance of microbial growth capability still plays a crucial role to control the performance of butanol production. The quantitative findings in toxicological terms directly suggest that the BtOH toxicity seemed to be inevitable during BtOH production. In addition, butanol inhibition could be reversibly attenuated by removal of butanol to make it below the critical level (ca. 7.83-9.52 g/L or EC50). C 2012 Elsevier B.V. All rights reserved.
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