Review
Biochemistry & Molecular Biology
Taobo Hu, Wei Hou, Enhua Xiao, Mengping Long
Summary: Stress granules are cytoplasmic foci induced by stress conditions, serving as a protective strategy to suppress overall translation. In cancer cells, stress granules formation can protect cells from apoptosis and contribute to resistance against anticancer drugs or radiation treatment. However, further research is needed to understand the clinical implications of stress granules.
Review
Biochemistry & Molecular Biology
Purab Pal, G. Ekin Atilla-Gokcumen, Jonna Frasor
Summary: The imbalance between cell proliferation and cell death is a classic hallmark of cancer, and ceramide, a bioactive sphingolipid, is implicated in cancer. In addition to its effects on cell death and therapeutic efficacy, ceramide turnover to downstream sphingolipids plays an equally important role in driving pro-tumorigenic phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yongxiu Huang, Hongyao Peng, Anqi Zeng, Linjiang Song
Summary: Breast cancer is the most common malignant tumor in women, and its incidence is increasing. Chemotherapy is widely used as a treatment for breast cancer, but drug resistance poses a challenge. Peptides have shown promise in overcoming drug resistance in breast cancer cells through various mechanisms such as promoting apoptosis, inhibiting DNA repair, and improving the tumor microenvironment. Understanding the mechanisms of peptides in reversing drug resistance could lead to breakthroughs in breast cancer treatment.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chien-Jung Lin, Jen-Tuo Chen, Lin-Jhen Yeh, Rong-Chi Yang, Shih-Ming Huang, Teng-Wei Chen
Summary: This study found that Taraxacum mongolicum exerted strong cytotoxic effects on breast cancer cells, especially on triple-negative breast cancer cells. In addition, Taraxacum extracts inhibited cell migration and colony formation, and induced ribotoxic stress in breast cancer cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Minkyeong Lee, Changwon Yang, Gwonhwa Song, Whasun Lim
Summary: Eupatilin, a natural product, inhibits growth and induces apoptosis in colon cancer cells. It affects oxidative stress, endoplasmic reticulum stress, autophagic process, and targets multiple signaling pathways, preventing cell invasion. Additionally, it synergizes with standard anticancer drugs to enhance their efficacy in colon cancer treatment.
Review
Biochemistry & Molecular Biology
Mitra Behroozaghdam, Maryam Dehghani, Amirhossein Zabolian, Davood Kamali, Salar Javanshir, Farzaneh Hasani Sadi, Mehrdad Hashemi, Teimour Tabari, Mohsen Rashidi, Sepideh Mirzaei, Atefeh Zarepour, Ali Zarrabi, Danielle De Greef, Anupam Bishayee
Summary: Breast cancer is a common cancer in females and finding an effective therapeutic agent is crucial. Resveratrol, a polyphenol found in common foods, has been used to treat various diseases including breast cancer. Its anticancer mechanisms include inhibiting cell proliferation and reducing invasion and metastasis, and it may have synergistic effects when combined with other chemotherapy drugs. Nano drug delivery systems have been introduced to improve its bioavailability.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Review
Oncology
Liting Tang, Baohong Jiang, Hongbo Zhu, Ting Gao, Yu Zhou, Fuqiang Gong, Rongfang He, Liming Xie, Yuehua Li
Summary: CircRNAs, a new class of endogenous regulatory RNA molecules, play important roles in the initiation and progression of breast cancer, and have the potential to become new diagnostic and predictive biomarkers of breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Review
Cell Biology
Rebar N. Mohammed, Mohsen Khosravi, Heshu Sulaiman Rahman, Ali Adili, Navid Kamali, Pavel Petrovich Soloshenkov, Lakshmi Thangavelu, Hossein Saeedi, Navid Shomali, Rozita Tamjidifar, Alireza Isazadeh, Ramin Aslaminabad, Morteza Akbari
Summary: Balanced cell death and survival pathways, including anastasis, play a critical role in cell development and homeostasis. Anastasis is a natural cell recovery pathway that promotes the survival of damaged or tumor cells, and contributes to the development of malignancy and drug resistance.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Immunology
Mahdieh Shokrollahi Barough, Neda Jalili, Soodabe Shafiee, Malihe Salehi, Nazanin Naseri, Mohammad Amin Javidi, Aysooda Hosseinzadeh, Leila Farahmand
Summary: Blocking MUC1 resulted in overexpression of ER, PR, and HER2, leading to increased drug hypersensitization and reduced IC50 levels for Tamoxifen and Herceptin. MCF-7R cells showed positive response to Tamoxifen with decreased IC50 and enhanced apoptosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Oncology
Chenming Zhong, Zijun Xie, Shiwei Duan
Summary: This article summarizes important predictive ncRNA biomarkers reported in cancer patients treated with different immunotherapeutic modalities including monoclonal antibodies, small molecule inhibitors, cancer vaccines, and CAR-T cells. In addition, a concise discussion on forthcoming perspectives is provided, outlining technical approaches for the optimal utilization of immune-modulatory ncRNA biomarkers as predictive tools and therapeutic targets.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Cynthia Mark, Jin Sun Lee, Xiaojiang Cui, Yuan Yuan
Summary: Antibody drug conjugates (ADCs) combine monoclonal antibodies with cytotoxic drugs for selective delivery to cancer cells, optimizing treatment effectiveness. ADC research has significantly impacted breast cancer management, providing valuable options. However, important questions remain, such as drug sequencing and overcoming resistance mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Chemistry, Multidisciplinary
Ke Qian, Chao-yuan Tang, Li-ying Chen, Shuang Zheng, Yue Zhao, Li-sha Ma, Li Xu, Lu-hui Fan, Jian-dong Yu, Hong-sheng Tan, Ya-lan Sun, Li-li Shen, Yang Lu, Qi Liu, Yun Liu, Yang Xiong
Summary: Berberine can enhance the inhibitory effect of doxorubicin on breast cancer cells, reverse multidrug resistance by inhibiting the efflux function of ATP-binding cassette transporters, and downregulating their expression levels.
Review
Biochemistry & Molecular Biology
Mohammad Mahmoudi Gomari, Shadi Abkhiz, Taha Ghantab Pour, Ehsan Lotfi, Neda Rostami, Fatemeh Nafe Monfared, Babak Ghobari, Mona Mosavi, Behruz Alipour, Nikolay V. Dokholyan
Summary: The low efficiency of cancer treatment strategies is a major obstacle in developing cancer inhibitors. Peptidomimetics, a new class of agents, have been introduced to overcome the limitations of peptides and have shown effectiveness in inhibiting metastasis, angiogenesis, and cancerous cell growth.
MOLECULAR MEDICINE
(2022)
Article
Oncology
Md Faqrul Hasan, Kavya Ganapathy, Jiao Sun, Ayman Khatib, Thomas Andl, Julia N. Soulakova, Domenico Coppola, Wei Zhang, Ratna Chakrabarti
Summary: The long noncoding RNA PAINT plays a promotive role in prostate cancer progression, with its inhibition reducing cell proliferation and migration while improving drug sensitivity. This study establishes a novel oncogenic function of PAINT in prostate cancer, providing new insights for potential therapeutic strategies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Uttom Kumar, Marcos Castellanos-Uribe, Sean T. May, Ernesto Yague
Summary: Resistance to cancer therapeutics is a major cause of mortality, especially in cancers without targeted therapies. Cancer drug resistance can be intrinsic, acquired, or adaptive. This study focuses on understanding the genome-wide expression changes associated with long-term doxorubicin resistance in triple negative breast cancer cells. The findings suggest that adaptive resistance may play a role in the generation of long-term drug resistance.
Review
Biochemistry & Molecular Biology
Eli Arama, Luis Alberto Baena-Lopez, Howard O. Fearnhead
Summary: Apoptosis is a major form of programmed cell death that plays a crucial role in maintaining tissue homeostasis and developmental processes. Research has unraveled the molecular details of the apoptosis program and the regulatory mechanisms of caspase activation. Moreover, recent studies suggest the essential role of apoptotic proteins in nonlethal cellular functions during normal development, tissue repair, and regeneration.
Article
Multidisciplinary Sciences
Vaibhav Patil, Enda O'Connell, Leo R. Quinlan, Howard Fearnhead, Siobhan McMahon, Abhay Pandit
Summary: This study presents an in vitro model of mixed glial culture to induce inflammation by pro-inflammatory cytokines, replicating acute and chronic inflammatory phases associated with spinal cord injury. The researchers observed differential modulation of inflammatory pathways over 21 days, with mitochondrial dysfunction associated with cytokine treatment. The developed model, along with the high-throughput screening platform, facilitates the screening of anti-reactive glial therapeutics for SCI treatment.
Article
Biochemistry & Molecular Biology
Richard C. Brewster, Alison N. Hulme
Summary: Post-translational modifications (PTMs) play a crucial role in controlling protein structure and function in organisms, but their study is complicated due to difficulties in selectively introducing PTMs onto proteins. Designing reagents that accurately mimic PTMs and selectively modify specific amino acid residues in proteins is a challenging task.
Article
Chemistry, Multidisciplinary
Fatemeh Sahebazzamani, Saman Hosseinkhani, Leif A. Eriksson, Howard O. Fearnhead
Summary: The study investigated the impact of disrupting the ionic bond in Apaf-1 on apoptosome activation and caspase-3 activity using a split luciferase complementation assay. The results showed that the K192E mutation increased apoptosome formation and caspase activity, while mutations at D616 had varying effects.
Article
Biochemistry & Molecular Biology
Alan X. Zhao, Louise E. Horsfall, Alison N. Hulme
Summary: Spiro compounds with three-dimensional structures are attractive targets in drug discovery for enhancing protein interactions, solubility, and molecular modeling. A novel method has been developed for generating spiro-cephalosporin compounds through a Michael-type addition to the dihydrothiazine ring, leading to selective formation of spiro-cephalosporins in moderate to good yields.
Article
Multidisciplinary Sciences
Jennifer Ross, Zak McIver, Thomas Lambert, Cecilia Piergentili, Jasmine Emma Bird, Kelly J. Gallagher, Faye L. Cruickshank, Patrick James, Efrain Zarazua-Arvizu, Louise E. Horsfall, Kevin J. Waldron, Marcus D. Wilson, C. Logan Mackay, Arnaud Basle, David J. Clarke, Jon Marles-Wright
Summary: In this study, the structural relationship between the encapsulin shell and its protein cargo was investigated using cryo-electron microscopy and hydrogen/deuterium exchange mass spectrometry. The study revealed the arrangement of encapsulated ferritin decamers within the encapsulin nanocompartment and the dynamic behavior of the encapsulin shell pore.
Review
Cell Biology
Mahshid H. Dehkordi, Robert G. K. Munn, Howard O. Fearnhead
Summary: Caspases are a family of proteases that play crucial roles in cell death processes, particularly apoptosis. However, they are also involved in various non-apoptotic processes, especially in regulating neuronal cell behaviors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ellen Poot, Ander Maguregui, Valerie G. Brunton, Dirk Sieger, Alison N. Hulme
Summary: This review explores the combination of particle delivery systems and immunotherapy for the effective treatment of glioblastoma multiforme (GBM) over the past three years.
BIOORGANIC & MEDICINAL CHEMISTRY
(2022)
Article
Chemistry, Organic
Craig F. Steven, Martin Lee, Gary S. Nichol, Paul R. J. Davey, Elisabetta Chiarparin, Valerie G. Brunton, Alison N. Hulme
Summary: The fraction of sp(3)-hybdrised carbons (Fsp(3)) has been proposed to be an important consideration in medicinal chemistry. Small-molecule probes for Raman imaging are not optimized for biological applications. The study introduced modifications to a highly Raman-active motif and investigated the correlation between compound aggregation, Fsp(3), and crystal packing. Cellular imaging by stimulated Raman scattering microscopy provided insights for future Raman probe design.
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
(2022)
Article
Chemistry, Analytical
Edith Sandstroem, Chiara Vettorazzo, C. Logan Mackay, Lore G. Troalen, Alison N. Hulme
Summary: A DESI source was built and attached to a Bruker 7T SolariX FT-ICR-MS for in situ analysis of early synthetic dyestuffs. Optimization experiments determined the best conditions for analysis, which were then applied to modern and historical samples. The study demonstrated the applicability and potential of DESI-MS in the field of historical dye analysis, revealing the presence of known degradation products and byproducts in historical samples.
ANALYTICAL CHEMISTRY
(2023)
Article
Chemistry, Multidisciplinary
Manasa Punaha Ravindra, Martin Lee, Silviya Dimova, Craig F. Steven, Marie T. J. Bluntzer, Valerie G. Brunton, Alison N. Hulme
Summary: Small heteroaryl-diyne (Het-DY) tags with distinct vibrational frequencies and physiologically relevant cLog P were designed for multiplexed bioorthogonal Raman imaging. Pd-Cu catalyzed coupling, combined with the use of Lei ligand, improved overall yields of the desired Het-DY tags while reducing homocoupled side-products. The improved Log P of these tags was evident from their diffuse distribution in cellular uptake studies, and functionalizing tags with organelle markers enabled location-specific biological imaging. LC-MS and NMR assays showed that some heteroaryl-capped internal alkynes exhibited structure-dependent reactivity as nucleophile traps. These biocompatible Het-DY tags, with covalent reactivity, offer new opportunities for Raman bioorthogonal imaging.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Humanities, Multidisciplinary
Edith Sandstrom, Chiara Vettorazzo, C. Logan Mackay, Lore G. Troalen, Alison N. Hulme
Summary: This article focuses on the application of a recently built DESI source to characterize natural dyestuffs in historical textiles and presents initial imaging experiments. Optimization of the instrumental settings, geometrical parameters, and solvent system on the DESI-MS analysis was conducted. Preliminary results suggest that the dye application process has a large impact on the ionization efficiency of DESI-MS.
Article
Chemistry, Multidisciplinary
C. L. Logan Mackay, Jens Soltwisch, Bram Heijs, Karl W. Smith, Faye L. Cruickshank, Annika Nyhuis, Klaus Dreisewerd, Diego Cobice
Summary: Prostate cancer is usually treated with androgen deprivation therapy, which can be limited by the emergence of a more lethal 'castrate resistant' form of the disease. Intracrine pathways may generate growth-stimulating androgens, and mass spectrometry imaging allows for visualization of biomolecules in tissues.
Review
Chemistry, Analytical
Martin Lee, C. Simon Herrington, Manasa Ravindra, Kristel Sepp, Amy Davies, Alison N. Hulme, Valerie G. Brunton
Summary: Stimulated Raman histopathology (SRH) utilizes the intrinsic vibrational properties of lipids, proteins and nucleic acids to provide rapid and high-resolution imaging of tissue samples. Recent advances in instrumentation and computer aided diagnosis are enhancing the capabilities of SRH, while the use of other nonlinear modalities is opening up new possibilities for enhanced histopathology and in vivo pathology.
Article
Chemistry, Analytical
Summary: Dye analysis is a crucial tool in understanding the origins of materials in historical objects, providing valuable information for conservation and display decisions. This Technical Brief outlines the analytical methods used in dye and mordant analysis, helping to identify the most appropriate experimental conditions and instrumentation available.
ANALYTICAL METHODS
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)