Article
Chemistry, Multidisciplinary
Thomas Cheviet, Ilyana Gonzales, Suzanne Peyrottes
Summary: N-carbamoyl aziridines were transformed into alpha-methylene phosphonate aziridines through a unique mechanism in the presence of n-BuLi and the nucleophilic butyl. The nature of the final compound depends on the base used.
NEW JOURNAL OF CHEMISTRY
(2022)
Article
Chemistry, Medicinal
Redouane Tabti, Francois Lamoureux, Celine Charrier, Benjamin Ory, Dominique Heymann, Embarek Bentouhami, Laurent Desaubry
Summary: Current therapeutic approaches for osteoporosis have limitations and potential adverse effects, but some sulfonylamidines have been shown to inhibit the formation of osteoclasts, suggesting potential for the development of new drugs. Compound IN45 demonstrated significant inhibition at a low concentration, indicating promise for anti-osteoporotic drug development.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Chemistry, Organic
Bin Zhang, Lan Ruan, Yi-Kang Zhang, Haifan Zhang, Ranran Li, Peng An
Summary: A new type of nitrogen-doped nanographene was designed and synthesized by introducing NH into a hexa-peri-hexabenzocoronene (HBC) core. The nitrogen-doped nanographene can be functionalized through N-H derivatization and optical resolution of the chiral nanographene was achieved through modifications to the NH site. The emission intensity and fluorescence mechanism of the nanographene can be modulated by introducing various aryl groups with different substituents.
Article
Biochemistry & Molecular Biology
Andrea Eisenreichova, Evzen Boura
Summary: This article reports the crystal structure of the complex formed by SARS-CoV-2 nucleocapsid protein and 14-3-3 protein, revealing the details of the binding. The study found that the N protein forms a complex with 14-3-3 protein through phosphorylation, and the central binding groove of 14-3-3 protein plays a key role. These findings enhance our understanding of the viral infection mechanism.
JOURNAL OF STRUCTURAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lukas Trizna, Branislav Osif, Viktor Viglasky
Summary: This paper uses the G-QINDER tool to identify TG and AG repeat sequences in DNA that adopt unique structural motifs. The structures were found to be stable under certain conditions and could potentially play a regulatory role in cells. The stability of the AGAG motif is primarily dependent on the number of AG repeats in the sequence.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Hao Liu, Hualin Fan, Pengcheng He, Haixia Zhuang, Xiao Liu, Meiting Chen, Wenwei Zhong, Yi Zhang, Cien Zhen, Yanling Li, Huilin Jiang, Tian Meng, Yiming Xu, Guojun Zhao, Du Feng
Summary: This study reveals the critical role of the inner mitochondrial membrane protein PHB1 in regulating permeability and integrity of mitochondria. Loss of PHB1 leads to alterations in mitochondrial function and increased release of mtDNA, resulting in enhanced inflammatory responses. Inflammatory stresses downregulate PHB1 expression, leading to increased mtDNA release and inflammation.
Article
Nanoscience & Nanotechnology
Yunhui Zhu, Yinghan Xu, Jianming Yan, Yuxin Fang, Na Dong, Anshan Shan
Summary: The study designed a series of antimicrobial peptides with immunostimulatory and bacteria-killing activities using a chemotactic motif. Among them, KWH2 exhibited potent antimicrobial activity against Gram-negative bacteria and activated macrophages. The study also provided insights into the mechanisms and possible approaches for developing immunomodulatory antimicrobial materials with desired properties.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Article
Chemistry, Multidisciplinary
Hadi Dolati, Lars Denker, Juan Pablo Martinez, Bartosz Trzaskowski, Rene Frank
Summary: This article describes the isolation of a rare parent iminoborane and stable (AmIm)B=N-SiMe3 species using the amino imidazoline-2-imine ligand system. The chemical behavior of these compounds differs significantly from organic imines.
CHEMISTRY-A EUROPEAN JOURNAL
(2023)
Article
Oncology
Jiahui Zhang, Yanan Yin, Jiahui Wang, Jingjing Zhang, Hua Liu, Weiwei Feng, Wen Yang, Bruce Zetter, Yingjie Xu
Summary: This study investigates the characteristics of tumor cell proliferation, the role of the PI3K-Akt-mTOR axis, and the interaction between FKBP8 and PHB1, suggesting that PHB1 may act as a potential regulator of FKBP8.
FRONTIERS OF MEDICINE
(2021)
Article
Biology
Yaqin Yan, Jintian Tang, Qinfeng Yuan, Caiyun Liu, Xiaolin Chen, Hao Liu, Junbin Huang, Chonglai Bao, Tom Hsiang, Lu Zheng
Summary: Prohibitins play important roles in fungal virulence by regulating mitophagy, affecting the pathogenicity of Colletotrichum higginsianum.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Geetika Bassi, Suresh Mishra
Summary: Mitochondria play a crucial role in steroidogenesis, particularly in cholesterol transport and P450scc enzyme synthesis. A study on transgenic mice reveals that PHB1 has a regulatory role in Leydig cell steroidogenesis, involving cell signaling, cholesterol homeostasis, and mitochondrial biology.
Editorial Material
Plant Sciences
Le Luo, Yuanming Xie, Wei Xuan
Summary: This study investigates the mechanism of lateral root formation in plants and identifies prohibitin 3 as a regulator of lateral root initiation. Prohibitin 3 affects the accumulation of endogenous nitric oxide and degradation of IAA proteins, leading to the activation of lateral root initiation.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Microbiology
Can Zhang, Meng Cai, Shanshan Chen, Fan Zhang, Tongshan Cui, Zhaolin Xue, Weizhen Wang, Borui Zhang, Xili Liu
Summary: In this study, a glycoproteomic analysis of Phytophthora sojae was conducted to identify N-glycosylated proteins, confirming the essential role of multiple N-glycosylation motifs in the growth of this oomycete. Through mutagenesis experiments, it was demonstrated that N-glycosylation of specific proteins is crucial for cyst germination and oospore production. These findings provide insights into the role of N-glycosylation in the development of oomycetes.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Biochemical Research Methods
Fatemeh Farhadi, Mohammad Allahbakhsh, Ali Maghsoudi, Nadieh Armin, Haleh Amintoosi
Summary: In this research, a computational approach called DiMo is proposed for identifying motifs in microRNAs and macromolecules of small length. Word embedding techniques and deep learning models are utilized to improve the accuracy of motif discovery, and transfer learning models are employed in cases of limited training data. Compared to five state-of-the-art works using real-world datasets, DiMo outperforms in terms of precision, recall, accuracy, and f1-score.
BRIEFINGS IN BIOINFORMATICS
(2023)
Article
Biochemistry & Molecular Biology
Pooppadi Maxin Sayeesh, Mayumi Iguchi, Yusuke Suemoto, Jin Inoue, Kohsuke Inomata, Teppei Ikeya, Yutaka Ito
Summary: Drk, a homologue of human GRB2 in Drosophila, receives signals from outside the cells through the interaction of its SH2 domain with the phospho-tyrosine residues in the intracellular regions of receptor tyrosine kinases (RTKs) and transduces the signals downstream through the association of its N- and C-terminal SH3 domains with proline-rich motifs (PRMs) in Son of Sevenless (Sos) or Daughter of Sevenless (Dos). The affinity of the SH3 domains towards Sos and Dos was assessed using NMR titration experiments, revealing that Sos-S1 binds to Drk-NSH3 with the highest affinity and that the two Sos-derived PRMs favor NSH3 for binding, while the two Dos-derived PRMs show similar affinity for both NSH3 and CSH3. Docking simulations based on chemical shift perturbations caused by Sos and Dos-derived peptides were also performed to further understand the interactions of Drk with Sos/Dos.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Muxin Yu, Hong Pan, Nan Che, Li Li, Cong Wang, Yue Wang, Ge Ma, Mengjia Qian, Jiawei Liu, Mingjie Zheng, Hui Xie, Lijun Ling, Yi Zhao, Xiaoxiang Guan, Qiang Ding, Wenbin Zhou, Shui Wang
Summary: Microwave ablation (MWA) of primary breast cancer activates NK cells, inhibiting lung metastasis and improving survival. NK cells exhibit enhanced cytotoxic functions post-MWA, playing a pivotal role in this process.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Review
Cell Biology
Wenwen Zhang, Xiaoxiang Guan, Jinhai Tang
Summary: Triple-negative breast cancer (TNBC) is known for its aggressive behavior and poor prognosis. Recent studies have identified various long non-coding RNAs (lncRNAs) that play important roles in TNBC tumorigenesis. Potential therapeutic strategies using lncRNAs are being explored in clinical settings for TNBC patients.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Kun Xu, Wenwen Zhang, Cong Wang, Longfei Hu, Runtian Wang, Cenzhu Wang, Lin Tang, Guohua Zhou, Bingjie Zou, Hui Xie, Jinhai Tang, Xiaoxiang Guan
Summary: This study revealed the cellular and molecular mechanisms of breast cancer lymph node metastasis using single-cell RNA sequencing and chromatin accessibility sequencing, identifying a novel cell subpopulation with aberrantly high expression of CXCL14 in lymph node metastases. Validation through tissue microarray and database analysis confirmed the significance of CXCL14 in lymph node metastasis of breast cancer. Additionally, potential regulatory transcription factors were identified through scATAC-seq for breast cancer lymph node metastasis.
HUMAN MOLECULAR GENETICS
(2021)
Article
Oncology
Lin Tang, Chengjun Zhu, Juan Jin, Xin Wang, Lingyue Yu, Xiaoxiang Guan
Summary: The study revealed that CDK7 is overexpressed in breast cancer, with a strong correlation to hypomethylation status and CNVs. CDK7 protein levels vary significantly among different subtypes of breast cancer, and high CDK7 expression is significantly associated with poor overall survival.
TRANSLATIONAL CANCER RESEARCH
(2021)
Review
Oncology
Swarnalatha Manickavinayaham, Briana K. Dennehey, David G. Johnson
Summary: RB and E2F proteins collaborate to regulate the cell cycle in eukaryotes and also have important functions in DNA repair. In some organisms, other proteins have taken over the cell cycle regulation function of RB and E2F. Apart from cell cycle regulation, E2F and RB homologs in various organisms also possess non-canonical functions.
Review
Biochemistry & Molecular Biology
Runtian Wang, Kun Xu, Fangyan Gao, Jinyi Huang, Xiaoxiang Guan
Summary: The formation of cyclinD-CDK4/6 complex is essential for the cell cycle transition from G1 phase to S phase. CDK4/6 inhibitors can block cell cycle progression and proliferation, showing promising effects in containing the aggressiveness of breast cancers, particularly in triple-negative breast cancer.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Review
Biochemistry & Molecular Biology
Yinxing Zhu, Yixuan Hu, Cuiju Tang, Xiaoxiang Guan, Wenwen Zhang
Summary: “Due to the lack of hormone receptors, triple negative breast cancer patients have limited benefits from endocrine or molecular targeted therapies, resulting in aggressive disease with high recurrence rate and poor prognosis. Chemotherapy has been the main treatment, but there are concerns about the cardiotoxicity of anthracyclines and drug resistance. Platinum-based chemotherapy has become a research focus, and this article summarizes the progress of clinical trials on platinum-containing regimens for TNBC patients and potential biomarkers.”
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2022)
Article
Biochemistry & Molecular Biology
Wenwen Zhang, Shuofei Yang, Datian Chen, Daolu Yuwen, Juan Zhang, Xiaowei Wei, Xin Han, Xiaoxiang Guan
Summary: The study revealed that PAI-1 induced lncRNA SOX2-OT can promote TNBC cell metastasis and activate the PI3K/Akt signaling pathway through the miR-942-5p/PIK3CA signaling pathway. These findings highlight the potential of developing new therapies for TNBC based on targeting SOX2-OT.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Yunzhu Shen, Baoguo Zhang, Xiaowei Wei, Xiaoxiang Guan, Wenwen Zhang
Summary: By analyzing the gene expression profile of brain metastases and primary TNBC, we identified CXCL8 as the only gene associated with prognostic indicators in TNBC brain metastasis. Functional analysis revealed CXCL8's association with immune response and infiltration. In addition, CXCL8 showed a positive correlation with immune-related scores and different types of immune cell infiltration. Our findings suggest that CXCL8 can serve as a prognostic biomarker and is associated with TNBC brain metastasis and immune infiltration.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Chemistry, Physical
Wei Liu, Wenfang Miao, Yang Li, Doudou He, Yuxia Tang, Xiaoxiang Guan, Cuiying Li, Feiyun Wu, Jinhai Tang, Shouju Wang
Summary: Hybridized periodic mesoporous organosilica (PMO) nanoparticles with double-shell structure incorporating gold colloid were synthesized, showing excellent photothermal conversion and ultrasound signal generation performance. Encapsulated with PFH, the nanoparticles demonstrated enhanced therapeutic efficacy and ultrasound contrast, indicating their potential as a theranostic platform for biomedical applications.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2022)
Review
Oncology
Cenzhu Wang, Kun Xu, Runtian Wang, Xin Han, Jinhai Tang, Xiaoxiang Guan
Summary: Breast cancer stem cells play a role in regulating the distant metastasis of breast cancer, and their heterogeneity varies according to biomarker status. Based on the seed and soil theory, BCSCs have an impact on the metastatic organotropism in breast cancer. Understanding the role of BCSCs could provide new insights for the diagnosis and treatment of advanced metastatic breast cancer.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Kun Xu, Runtian Wang, Hui Xie, Longfei Hu, Cong Wang, Jiali Xu, Chengjun Zhu, Yiqiu Liu, Fangyan Gao, Xintong Li, Cenzhu Wang, Jinyi Huang, Wenbin Zhou, Guohua Zhou, Yongqian Shu, Xiaoxiang Guan
Summary: This study utilized single-cell sequencing to analyze the transcriptome profile of breast cancer lymph node metastasis, identifying key breast cancer stem cells and their evolution, as well as revealing the interactions between breast cancer cells and tumor microenvironment cells.
Editorial Material
Oncology
Wenwen Zhang, Naoyuki Kataoka, Xiaoxiang Guan
FRONTIERS IN ONCOLOGY
(2021)
Article
Medicine, General & Internal
Chengjun Zhu, Jing Xu, Jinyu Sun, Shiyun Cui, Yue Sun, Tao Yu, Cenzhu Wang, Tianyao Wang, Yufeng Wu, Feng Ju, Jiafeng Yao, Kai Liu, Wenwen Zhang, Xiaoxiang Guan
Summary: This study investigates the association between circulating tumor cells (CTCs) and breast cancer metastasis. The results show that CTC enumeration is significantly associated with liver metastasis in breast cancer patients, and CTCs >= 5 are a risk factor for tumor metastasis. Furthermore, high CTC levels may be associated with an increased risk of liver metastasis in patients with metastatic breast cancer.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Cenzhu Wang, Kun Xu, Fei Deng, Yiqiu Liu, Jinyi Huang, Runtian Wang, Xiaoxiang Guan
Summary: The study revealed a negative correlation between TMB and lymph node metastasis in BC, and established a TMB-related signature for predicting lymph node metastasis in BC patients, which showed reliable efficacy.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
