Article
Plant Sciences
Bingbing Guo, Longjun Dai, Hong Yang, Xizhu Zhao, Mingyang Liu, Lifeng Wang
Summary: This study identified HbBRI1 and HbBAK1 genes in rubber tree and found their crucial role in plant hormone signal transduction. The expression of HbBRI1 and HbBAK1 genes is significantly induced by different hormone stimuli. These findings provide a theoretical basis for further research on the functions of BR receptors in the rubber tree.
Article
Biochemistry & Molecular Biology
Sara Kim, Jeonghyang Park, Byeong Wook Jeon, Geonhee Hwang, Na Young Kang, Yeim We, Won-Young Park, Eunkyoo Oh, Jungmook Kim
Summary: This study presents an engineered rapamycin-inducible dimerization receptor system that can trigger LRR-RK signaling independent of ligands or endogenous receptors. By using this system, the authors demonstrated that rapamycin-mediated association can activate downstream brassinosteroid signaling and immune responses, while also revealing the potential functions and differential activities of some LRR-RKs in immune signaling.
Article
Agronomy
Yanli Zhang, Guojun Dong, Fei Chen, Erhui Xiong, Huijie Liu, Yaohuang Jiang, Guosheng Xiong, Banpu Ruan, Qian Qian, Dali Zeng, Dianrong Ma, Yanchun Yu, Limin Wu
Summary: Phytohormones, including brassinosteroids (BRs), play critical roles in regulating plant architecture in rice. This study reveals that BR hypersensitive1 (BHS1) acts as a negative regulator in BR signaling and regulates rice architecture by controlling grain length. The degradation of BHS1 is induced by BR treatment and involves both transcriptional and posttranscriptional regulation mechanisms. The findings suggest that BHS1 is a novel component downstream of BRI1 involved in negative regulation of the BR signaling pathway.
THEORETICAL AND APPLIED GENETICS
(2022)
Article
Plant Sciences
Chan Ho Park, Yang Bi, Ji-Hyun Youn, So-Hee Kim, Jung-Gun Kim, Nicole Y. Xu, Ruben Shrestha, Alma L. Burlingame, Shou-Ling Xu, Mary Beth Mudgett, Seong-Ki Kim, Tae-Wuk Kim, Zhi-Yong Wang
Summary: This study reveals that two plant receptor kinases regulate different cellular responses through phosphorylation of a shared phosphatase. The results demonstrate the important role of BSU1 in immunity and show how different phosphorylation sites are used to transduce signals from brassinosteroid and flagellin receptors.
Article
Plant Sciences
Mingqian Liu, Mingmin Lu, Ziwei Zhao, Qin Luo, Feng Liu, Jing Zhao, Yubing He, Yanan Tian, Huadong Zhan
Summary: This study systematically characterized the INCREASED LEAF INCLINATION (ILI) subfamily of atypical bHLH transcription factors in rice. The ILIs play diverse and essential roles in BR-mediated growth and development, with ILI4 and ILI5 having a more prominent function. The ILIs were found to interact with OsbHLH157 and OsbHLH158, counteracting their effects in regulating downstream gene expression and maintaining the balance of BR signaling.
Article
Biochemistry & Molecular Biology
Xiaojie Tian, Mingliang He, Enyang Mei, Baowen Zhang, Jiaqi Tang, Min Xu, Jiali Liu, Xiufeng Li, Zhenyu Wang, Wenqiang Tang, Qingjie Guan, Qingyun Bu
Summary: The study reveals the crosstalk between WRKY53, BR signaling, and the MAPK pathway in regulating plant architecture and seed size. GSK2 plays a crucial role in this interplay by phosphorylating WRKY53 and MAPKK4. The findings highlight the complex regulatory mechanisms involved in controlling rice yield.
Article
Cell Biology
Dawei Zhang, Wenrong Tan, Feng Yang, Qing Han, Xingguang Deng, Hongqing Guo, Baohui Liu, Yanhai Yin, Honghui Lin
Summary: GSK3-like kinases in Arabidopsis play roles in plant development, including chloroplast development, and are regulated by BIN2 through phosphorylation. The interaction between BIN2 and GLK1/2 affects chloroplast development and responses to BRs/darkness, modulating photomorphogenesis.
DEVELOPMENTAL CELL
(2021)
Article
Plant Sciences
Jingjie Zhang, Weiyue Chen, Xiaopeng Li, Hongyong Shi, Minghui Lv, Liming He, Wenhua Bai, Shujing Cheng, Jinfang Chu, Kai He, Xiaoping Gou, Jia Li
Summary: An apical hook is a crucial structure in dicotyledonous plants that protects the shoot apical meristem during seed germination and hypocotyl elongation. Previous studies have shown that the phytohormones BR and JA regulate apical hook formation antagonistically. This study reveals that JAs repress BRs by inhibiting the transcriptional activation of BZR1 by MYC2, disrupting the interaction between BZR1 and its partner transcription factors, and downregulating the expression of target genes important for apical hook development.
Article
Multidisciplinary Sciences
Bingying Zhou, Qing Luo, Yanghui Shen, Liang Wei, Xia Song, Hangqian Liao, Lan Ni, Tao Shen, Xinglin Du, Junyou Han, Mingyi Jiang, Shengjun Feng, Gang Wu
Summary: Vegetative phase change in plants is regulated by a decline in miR156 and an increase in SPL genes. Brassinosteroids (BR) stabilize SPL9 and TOE1 to regulate this process through BIN2-mediated phosphorylation. The study reveals a new role for BR in the regulation of vegetative phase change in Arabidopsis.
NATURE COMMUNICATIONS
(2023)
Review
Biochemical Research Methods
Elizabeth Pacheco Batista Fontes, Ruan Maloni Teixeira, Rosa Lozano-Duran
Summary: Plants have developed multilayered molecular defense strategies to combat pathogens, but some mechanisms may be hidden by the immune-suppressing functions from co-evolving pathogens. Recent studies on begomovirus-host interactions have provided insights into how suppressed plant antiviral mechanisms offer a dynamic view of evolving pressures in the immune system, and the crosstalk between host antiviral defenses and antibacterial immunity.
CURRENT OPINION IN BIOTECHNOLOGY
(2021)
Article
Plant Sciences
Lucas Alves Neubus Claus, Derui Liu, Ulrich Hohmann, Nemanja Vukasinovic, Roman Pleskot, Jing Liu, Alexei Schiffner, Yvon Jaillais, Guang Wu, Sebastian Wolf, Daniel Van Damme, Michael Hothorn, Eugenia Russinova
Summary: A BR binding-deficient Arabidopsis mutant was designed to re-examine the BRI1 endocytosis and signal attenuation model. The study showed that despite impaired phosphorylation and ubiquitination, the BR binding-deficient BRI1 can still internalize, indicating that BRI1 internalization relies on different endocytic machineries. Furthermore, the mutant provides opportunities to study non-canonical ligand-independent BRI1 functions.
Article
Forestry
Luiz Gustavo Martinelli Delgado, Richardson Barbosa Gomes da Silva, Monica Moreno Gabira, Angelica Lino Rodrigues, Danilo Simoes, Luiz Fernando Rolim de Almeida, Magali Ribeiro da Silva
Summary: This study analyzed the effects of different mean leaf angles on irrigation efficiency and physiological responses of tree seedlings. The results showed that tree species with positive mean leaf angles exhibited improved physiological responses with smaller irrigation depths, while species with negative mean leaf angles required larger irrigation depths to maintain normal physiological responses.
Article
Plant Sciences
Liangliang Chen, Alicia M. M. Cochran, Jessica M. M. Waite, Ken Shirasu, Shannon M. M. Bemis, Keiko U. U. Torii
Summary: Plants perceive signals through cell-surface receptors to coordinate their development and environmental response. PUB30 and PUB31, two closely related ubiquitin E3 ligases, regulate ERECTA signaling by promoting its degradation, thereby ensuring optimal signaling outputs for inflorescence/pedicel growth and stomatal development.
Article
Plant Sciences
Ting Ma, Jun-Ru Tan, Yan Zhang, Sha Li
Summary: Arabidopsis atypical R-SNARE protein YKT61 plays a key role in brassinosteroid (BR)-mediated root development by modulating the dynamic targeting of the BR receptor BRASSINOSTEROID-INSENSITIVE1.
Article
Multidisciplinary Sciences
Jiaojiao Bai, Yuanyuan Zhou, Jianhang Sun, Kexin Chen, Yufang Han, Ranran Wang, Yanmin Zou, Mingshuo Du, Dongping Lu
Summary: Plant innate immunity relies on the protein BIK1, which is regulated by the ubiquitin ligases RGLG1/2 and PUB25. RGLG1/2 promote BIK1 accumulation and immune signaling, while PUB25 mediates BIK1 degradation. The interplay between these ubiquitin ligases maintains BIK1 homeostasis and regulates immune responses.
NATURE COMMUNICATIONS
(2023)
Article
Plant Sciences
Si-in Yu, Jin-Hee Han, Chanvotey Chhoeun, Byeong-ha Lee
FRONTIERS IN PLANT SCIENCE
(2016)
Article
Plant Sciences
Hemasundar Alavilli, Jay Prakash Awasthi, Gyana R. Rout, Lingaraj Sahoo, Byeong-ha Lee, Sanjib Kumar Panda
FRONTIERS IN PLANT SCIENCE
(2016)
Article
Biochemistry & Molecular Biology
Soo-Jung Kwon, Ok-Seon Kwon, Keun-Tae Kim, Young-Hyun Go, Si-in Yu, Byeong-ha Lee, Hiroyuki Miyoshi, Eunsel Oh, Seung-Ju Cho, Hyuk-Jin Cha
Article
Plant Sciences
Hemasundar Alavilli, Hyoungseok Lee, Mira Park, Dae-Jin Yun, Byeong-ha Lee
PLANT CELL REPORTS
(2018)
Article
Plant Sciences
Geun-Don Kim, Young-Hee Cho, Byeong-Ha Lee, Sang-Dong Yoo
Article
Plant Sciences
Sungkyung Cho, Si-in Yu, Junghoon Park, Yanfei Mao, Jian-Kang Zhu, Dae-Jin Yun, Byeong-ha Lee
FRONTIERS IN PLANT SCIENCE
(2017)
Article
Plant Sciences
Hemasundar Alavilli, Hyoungseok Lee, Mira Park, Byeong-ha Lee
FRONTIERS IN PLANT SCIENCE
(2017)
Article
Biochemistry & Molecular Biology
Mira Park, Hyun Park, Hyoungseok Lee, Byeong-ha Lee, Jungeun Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2018)
Article
Multidisciplinary Sciences
Mira Park, Soon Gyu Hong, Hyun Park, Byeong-ha Lee, Hyoungseok Lee
Article
Multidisciplinary Sciences
Junghoon Park, Chae Jin Lim, Mingzhe Shen, Hee Jin Park, Joon-Yung Cha, Elisa Iniesto, Vicente Rubio, Tesfaye Mengiste, Jian-Kang Zhu, Ray A. Bressan, Sang Yeol Lee, Byeong-ha Lee, Jing Bo Jin, Jose M. Pardo, Woe-Yeon Kim, Dae-Jin Yun
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2018)
Article
Biochemistry & Molecular Biology
Si-in Yu, Hyojin Kim, Dae-Jin Yun, Mi Chung Suh, Byeong-ha Lee
PLANT MOLECULAR BIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Hyojin Kim, Si-in Yu, Seh Hui Jung, Byeong-ha Lee, Mi Chung Suh
Review
Plant Sciences
Jae-Young Yun, Si-in Yu, Seung-eun Bang, Jae-Yeon Kim, Sang Ho Lee, Byeong-ha Lee
Summary: This review summarizes several CRISPR mutant screening methods, with a detailed focus on the analysis based on Next-Generation Sequencing (NGS). NGS screening is accurate, quantitative, and suitable for large-scale screening, making it a promising strategy for gene editing in plants.
JOURNAL OF PLANT BIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Seher Yolcu, Hemasundar Alavilli, Byeong-ha Lee
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Biochemistry & Molecular Biology
Soong-Taek Hwang, Huiling Li, Hemasundar Alavilli, Byeong-ha Lee, Dongsu Choi
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2017)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)