Article
Biochemistry & Molecular Biology
Kaicheng Yang, Jianguang Zhao, Shenghui Liu, Shasha Man
Summary: TFAP2A overexpression is observed in many cases of OSCC, and the key signaling pathway associated is the RELA-TFAP2A-Wnt/β-catenin pathway. It was found that upregulation of RELA can promote the progression of OSCC, and TFAP2A activates the Wnt/β-catenin signaling pathway by targeting the promoter regions of β-catenin. The study suggests that the RELA-TFAP2A-Wnt/β-catenin pathway is a potential target for reducing the aggressiveness of OSCC.
MOLECULAR CARCINOGENESIS
(2023)
Article
Oncology
Dan Fang, Mu-Ru Wang, Jia-Lun Guan, Ying-Ying Han, Jia-Qi Sheng, De-An Tian, Pei-Yuan Li
Summary: The study found that in HCC, high expression of BRD9 was closely related to malignancy, tumor stage, tumor size, and prognosis. BRD9 promoted cell proliferation and tumor growth, and mediated its effects by activating the Wnt/beta-catenin signaling pathway.
EXPERIMENTAL CELL RESEARCH
(2021)
Article
Dentistry, Oral Surgery & Medicine
Sheng-Hai Cui, Xiao-Di Hu, Yan Yan
Summary: miR-626 targets RASSF4 to regulate the biological characteristics of oral squamous cell carcinoma (OSCC) cells, including proliferation, invasion, migration, epithelial-mesenchymal transition (EMT), and apoptosis, possibly through the Wnt/β-Catenin pathway.
JOURNAL OF ORAL PATHOLOGY & MEDICINE
(2021)
Article
Biotechnology & Applied Microbiology
Chunyan Qiao, Tianyi Qiao, Shihui Yang, Lili Liu, Mengdan Zheng
Summary: The research revealed that upregulated SNHG17 in oral squamous cell carcinoma (OSCC) promoted cell growth by activating the Wnt/beta-catenin signaling pathway. ELF1 was identified as the transcription activator of CTNNB1 (beta-catenin mRNA) and played a crucial role in SNHG17-mediated OSCC cell growth. Additionally, SNHG17 and ELF1 acted as competing endogenous RNAs (ceRNAs) in OSCC by competitively binding to miR-384, regulating cell growth in the ceRNA network.
CANCER GENE THERAPY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Ruimin Zhao, Shiyang Wang, Lu Tan, Huajing Li, Junsong Liu, Shaoqiang Zhang
Summary: The study found that IGFL2-AS1 was highly expressed in tongue squamous cell carcinoma (TSCC) and had an impact on cell proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT). IGFL2-AS1 acted as a competing endogenous RNA (ceRNA) by regulating the expression of miR-1224-5p and SATB homeobox 1 (SATB1), thereby regulating the Wnt/beta-catenin signaling pathway and TSCC progression.
Article
Medicine, Research & Experimental
Huan Ji, Haiyang Song, Zeyu Wang, Pengfei Jiao, Jiani Xu, Xuan Li, Hongming Du, Heming Wu, Yi Zhong
Summary: This study identifies FAM83A as an oncogene of HNSCC with overexpression significantly associated with tumor size, lymph node status, and clinical tumor stages. FAM83A promotes HNSCC cell growth and metastasis by inducing EMT through activation of the Wnt/beta-catenin signaling pathway. Knockdown of FAM83A suppresses tumor growth and distant metastasis in xenograft animal models of HNSCC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Cell Biology
Yunjiu Gou, Dacheng Jin, Shengliang He, Songchen Han, Qizhou Bai
Summary: RNF168 is found to be overexpressed in ESCC and associated with tumor stage and depth of invasion. Knockdown of RNF168 inhibits esophageal cancer cell proliferation, promotes apoptosis, interferes with cell movement, and ultimately suppresses tumor growth. RNF168 influences malignant behavior of esophageal cancer cells through regulating the Wnt/β-catenin signaling pathway.
Article
Oncology
Chun Tang, Xuehui Wang, Changle Ji, Wenfang Zheng, Yunhe Yu, Xiaochong Deng, Xiqian Zhou, Lin Fang
Summary: The study demonstrated that miR-640 suppresses the tumorigenesis of breast cancer cells by regulating the Wnt/β-catenin signaling pathway, making it a potential novel target for targeted therapy in breast cancer.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Sangeeta Ghuwalewala, Dishari Ghatak, Sumit Das, Stuti Roy, Pijush Das, Ramesh Butti, Mahadeo Gorain, Somsubhra Nath, Gopal C. Kundu, Susanta Roychoudhury
Summary: The study found an elevated expression of miR-146a in the CD44(high)CD24(low) population within OSCC cells and primary HNSCC tumors. Over-expression of miR-146a enhances stemness phenotype by stabilizing beta-catenin and resulting in loss of E-cadherin and CD24. CD24 is identified as a novel functional target of miR-146a, and mechanistic analysis reveals that higher CD24 levels inhibit AKT phosphorylation leading to beta-catenin degradation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Jue Wang, Nanning Sheng, Ying Li, Yawei Fan, Xinrong Nan, Rong Fu
Summary: Overexpression of Ly6D contributes to chemoresistance in laryngeal squamous cell carcinoma (LSCC) cells, while silencing Ly6D abolishes this phenotype. Activation of the Wnt/beta-catenin pathway is involved in Ly6D-mediated chemoresistance. Ly6D overexpression attenuates the expression of miR-509-5p, which unleashes CTNNB1 to activate Wnt/beta-catenin pathway and promote chemoresistance.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Cell Biology
Meng Wang, Zhigang Feng, Xiaoxi Li, Shulan Sun, Li Lu
Summary: LncRNA HCG22 is lowly expressed in OSCC cells and exerts anti-tumor properties by inhibiting the Akt, mTOR, and Wnt/beta-catenin pathways.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Cell Biology
Xiaoxuan Duan, Yihuan Chen, Kai Zhang, Wei Chen, Jun Zhao, Xiaoshuo Dai, Wenbo Cao, Ziming Dong, Saijun Mo, Jing Lu
Summary: This study found that phosphoglycerate dehydrogenase (PHGDH) was highly expressed in esophageal squamous carcinoma (ESCC), and high expression was associated with poor prognosis. In vitro and in vivo experiments demonstrated that PHGDH knockdown inhibited ESCC progression by suppressing Wnt/beta-catenin signaling pathway. These results indicate that PHGDH may be a potential therapeutic target for ESCC.
CELLULAR SIGNALLING
(2023)
Article
Biochemistry & Molecular Biology
Erin A. Nekritz, Ruth Rodriguez-Barrueco, Koon-Kiu Yan, Meredith L. Davis, Rachel L. Werner, Laura Devis-Jauregui, Partha Mukhopadhyay, Jiyang Yu, David Llobet-Navas, Jose Silva
Summary: The miR-424/503 cluster plays a crucial role in regulating Wnt signaling, MaSC fate, and breast cancer development, with its function involving targeting the LRP6 co-receptor to reduce its expression.
Article
Biochemistry & Molecular Biology
Hao Zhang, Si Shen, Chong Feng, Gang Chen, Xinxing Wang
Summary: Microfibrillar-associated protein 2 (MFAP2) is involved in the development and progression of oral squamous cell carcinoma (OSCC). High expression of MFAP2 is associated with poor prognosis in OSCC patients. MFAP2 promotes oncogenic autophagy and upregulates the Wnt/beta-catenin signaling pathway to stimulate OSCC development.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2023)
Article
Cell Biology
Mustafa Karabicici, Yagmur Azbazdar, Gunes Ozhan, Serif Senturk, Zeynep Firtina Karagonlar, Esra Erdal
Summary: In this study, it was found that regorafenib treatment activated Wnt/beta-catenin signaling only in hepatoblast-like HCC cell lines and induced enrichment of markers associated with hepatic stem/progenitor cells. On the other hand, regorafenib resistant cells demonstrated diminished Wnt/beta-catenin signaling activity and enhanced TGF-beta signaling activity. The inhibition of TGF-beta pathway in combination with regorafenib administration might increase regorafenib-induced cell death in HCC tumors with aberrant activation in the Wnt/beta-catenin pathway.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Psychology, Clinical
Ana Catalan, Stefania Tognin, Matthew J. Kempton, Daniel Stahl, Gonzalo Salazar de Pablo, Barnaby Nelson, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Lucia R. Valmaggia, Philip McGuire
Summary: This study found that individuals at clinical high-risk for psychosis have a reasoning bias known as "jumping to conclusions." The study found that this bias was not associated with the subsequent onset of psychosis, but individuals who developed psychosis showed a greater tendency to jump to conclusions compared to those who did not develop psychosis and healthy controls. This tendency to jump to conclusions was significantly associated with adverse functioning during follow-up.
PSYCHOLOGICAL MEDICINE
(2022)
Article
Psychology, Clinical
David van den Berg, Eva Tolmeijer, Alyssa Jongeneel, Anton B. P. Staring, Eline Palstra, Mark van der Gaag, Amy Hardy
Summary: The study examines the relationship between trauma and voice-hearing in people with psychosis. The findings suggest that trauma plays a significant role in shaping the content and psychological impact of voices. However, more research is needed to better understand these mechanisms.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Psychiatry
Stefania Tognin, Ana Catalan, Matthew J. Kempton, Barnaby Nelson, Patrick McGorry, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Jim van Os, Lieuwe de Haan, Mark van der Gaag, Philip R. McGuire, Lucia Valmaggia
Summary: Research shows that adverse childhood experiences (ACE) can impact educational achievements in individuals at clinical high risk of psychosis (CHR). Specifically, CHR individuals with ACE had lower education levels, employment rates, and estimated IQ compared to healthy controls. Early intervention programs for psychosis should integrate interventions to support the educational and vocational recovery of young CHR individuals, and public health and social interventions to prevent or reduce the impact of ACE are recommended.
EUROPEAN PSYCHIATRY
(2023)
Article
Psychiatry
Emily J. Hird, Noriyuki Ohmuro, Paul Allen, Peter Moseley, Matthew J. Kempton, Gemma Modinos, Gabriele Sachs, Mark van der Gaag, Lieuwe de Haan, Ary Gadelha, Rodrigo Bressan, Neus Barrantes-Vidal, Stephan Ruhrmann, Ana Catalan, Philip McGuire
Summary: The study found that individuals at clinical high risk for psychosis have a lower sensitivity to hearing speech in noise and uncertainty about the affective valence of this speech, which is associated with adverse clinical outcomes. The findings suggest that the ability to hear speech illusions in noise could be used as a cognitive marker to predict the likelihood of remission or transition to psychosis in individuals at risk.
SCHIZOPHRENIA BULLETIN
(2023)
Article
Psychology, Clinical
Alyssa Jongeneel, Ilan Libedinsky, Anouk Reinbergen, Nynke Tromp, Philippe Delespaul, Heleen Riper, Mark van der Gaag, David van den Berg
Summary: Temstem is a mobile application developed to help individuals cope with distressing voices. The study found that using Temstem reduced voice-hearing distress and the emotionality and vividness of voice memories.
INTERNET INTERVENTIONS-THE APPLICATION OF INFORMATION TECHNOLOGY IN MENTAL AND BEHAVIOURAL HEALTH
(2022)
Article
Psychology, Clinical
Simone R. Burger, Amy Hardy, Tineke van der Linden, Catherine van Zelst, Paul A. J. de Bont, Berber van der Vleugel, Anton B. P. Staring, Carlijn de Roos, Ad de Jongh, Machteld Marcelis, Agnes van Minnen, Mark van der Gaag, David P. G. van den Berg
Summary: This study investigated symptom exacerbation during trauma-focused therapy in people with PTSD and psychosis. The results showed that symptom exacerbation was common but not associated with poor treatment outcomes or treatment drop-out. Therefore, symptom exacerbation should not be a barrier to implementing trauma-focused therapy in this population.
JOURNAL OF TRAUMATIC STRESS
(2023)
Article
Immunology
Valeria Mondelli, Graham Blackman, Matthew J. Kempton, Thomas A. Pollak, Conrad Iyegbe, Lucia R. Valmaggia, Paul Amminger, Neus Barrantes-Vidal, Rodrigo Bressan, Mark van der Gaag, Lieuwe de Haan, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Anita Riecher-Roessler, Bart P. F. Rutten, Gabriele Sachs, Nikolaos Koutsouleris, Philip McGuire
Summary: Individuals at clinical high risk for psychosis show altered cytokine levels, with increased VEGF and IL-10/IL-6 ratio associated with the transition to psychosis. These findings suggest that peripheral immune markers play a role in the onset of psychosis.
BRAIN BEHAVIOR AND IMMUNITY
(2023)
Article
Clinical Neurology
Lucy A. Chester, Lucia R. Valmaggia, Matthew J. Kempton, Edward Chesney, Dominic Oliver, Emily P. Hedges, Elise Klatsa, Daniel Stahl, Mark van der Gaag, Lieuwe de Haan, Barnaby Nelson, Patrick McGorry, G. Paul Amminger, Anita Riecher-Rossler, Erich Studerus, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Birte Glenthoj, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Philip McGuire
Summary: The aim of this study was to investigate the association between cannabis use and the incidence of psychotic disorders in individuals at clinical high risk of psychosis. The results showed no significant association between cannabis use and the transition to psychosis, persistence of symptoms, or functional outcome.
PSYCHIATRY AND CLINICAL NEUROSCIENCES
(2023)
Article
Medicine, Research & Experimental
Eva Tolmeijer, Felicity Waite, Louise Isham, Laura Bringmann, Robin Timmers, Arjan van den Berg, Hanneke Schuurmans, Anton B. P. (Tonnie) Staring, Paul de Bont, Rob van Grunsven, Gert Stulp, Ben Wijnen, Mark van der Gaag, Daniel Freeman, David van den Berg
Summary: This study aims to test the effectiveness and cost-effectiveness of the Feeling Safe-NL Programme in improving mental wellbeing and reducing persecutory delusions. The study will conduct a randomized controlled trial on 190 out-patients with persecutory delusions and low mental wellbeing, comparing the effects of the Feeling Safe-NL Programme and formulation-based CBTp.
Article
Psychology, Clinical
Jelle Sjoerd Vogel, Jojanneke Bruins, Marte Swart, Edith Liemburg, Mark van der Gaag, Stynke Castelein
Summary: This randomized controlled trial investigated the effects of an eating club intervention on personal and societal recovery in patients with a psychotic disorder. The intervention did not show any significant effects on personal recovery or secondary outcomes, but higher attendance was associated with better social functioning scores.
JOURNAL OF BEHAVIOR THERAPY AND EXPERIMENTAL PSYCHIATRY
(2023)
Article
Psychiatry
Frederike Schirmbeck, Els van der Ven, Lindy-Lou Boyette, Philip McGuire, Lucia R. Valmaggia, Matthew J. Kempton, Mark van der Gaag, Anita Riecher-Rossler, Neus Barrantes-Vidal, Barnaby Nelson, Marie-Odile Krebs, Stephan Ruhrmann, Gabriele Sachs, Bart P. F. Rutten, Merete Nordentoft, Lieuwe de Haan, Jentien M. Vermeulen
Summary: Study on individuals at ultra-high risk for psychosis found that persistent smoking is associated with unfavorable progress in psychotic symptoms, while smoking cessation is linked to improvement in affective symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Psychiatry
Emily P. Hedges, Hannah Dickson, Stefania Tognin, Gemma Modinos, Mathilde Antoniades, Mark van der Gaag, Lieuwe de Haan, Patrick McGorry, Christos Pantelis, Anita Riecher-Rossler, Rodrigo Bressan, Neus Barrantes-Vidal, Marie-Odile Krebs, Merete Nordentoft, Stephan Ruhrmann, Gabriele Sachs, Bart P. Rutten, Jim van Os, Lucia R. Valmaggia, Philip McGuire, Matthew J. Kempton
Summary: Individuals with clinical high risk for psychosis show deficits in verbal memory and verbal fluency, which are related to longer-term outcomes of the disorder. These cognitive impairments are present even in those not taking antipsychotic medication. Furthermore, impaired immediate verbal recall predicts functional disability and non-remission from the clinical high risk state.
SCHIZOPHRENIA RESEARCH-COGNITION
(2022)
Article
Pediatrics
Yvonne de Jong, Albert E. Boon, Daniek Gouw, Mark van der Gaag, Cornelis L. Mulder
Summary: Background screening methods for detecting Ultra High Risk (UHR) status or psychosis need improvement, especially in adolescent samples. This study tested whether the Child Behavior Checklist (CBCL) and the Youth Self Report (YSR) add value to the Prodromal Questionnaire-16 items version (PQ-16) for detecting UHR status or psychosis. The results showed that combining the YSR Thought Problems scale and the PQ-16 as a first-step screener improved the detection of UHR or psychosis in help-seeking adolescents.
CHILD AND ADOLESCENT PSYCHIATRY AND MENTAL HEALTH
(2022)
Correction
Psychiatry
Heleen S. van der Heijden, Frederike Schirmbeck, Matthew J. Kempton, Mark van der Gaag, Kelly Allott, Barnaby Nelson, Stephan Ruhrmann, Lieuwe de Haan, Jentien M. Vermeulen
EUROPEAN PSYCHIATRY
(2022)
Article
Criminology & Penology
Roos Ruijne, Cornelis Mulder, Milan Zarchev, Kylee Trevillion, Roel van Est, Eva Leeman, Willemien Willems, Mark van der Gaag, Carlo Garofalo, Stefan Bogaerts, Louise Howard, Astrid Kamperman
Summary: A cluster randomized controlled trial showed that training programs on DVA knowledge and skills in community mental health teams can improve knowledge and attitude towards DVA, but did not increase the detection or referral rates of DVA in patients with severe mental illness. Future interventions are recommended to include more mandatory elements and focus on improving communication between community mental health teams and DVA services.
JOURNAL OF INTERPERSONAL VIOLENCE
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
