期刊
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
卷 455, 期 3-4, 页码 251-255出版社
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bbrc.2014.10.154
关键词
Cancer; Cell-extracellular matrix adhesion; Migration; MT1-MMP; Vinculin
资金
- Kakenhi Grant from the Japan Society for the Promotion of Science (JSPS) - Japan [23590356]
- Grants-in-Aid for Scientific Research [25860233, 23590356] Funding Source: KAKEN
Vinculin regulates a variety of cellular functions partly through stabilization of tumor suppressor PTEN. In order to study the role of vinculin in tumor progression other than PTEN stabilization, vinculin was knocked down in PTEN-deficient squamous cell carcinoma HSC-4 cells. Knockdown of vinculin induced phenotypical change by reducing cell-cell and cell-extracellular matrix adhesions, and enhanced MT1-MMP expression at transcription level and subsequent cell migration. Up-regulation of MT1-MMP transcription by vinculin knockdown was abrogated by ERK inhibition. These results suggest that vinculin negatively regulates malignant phenotype of tumor cells including MT1-MMP transcription through MEK/ERK pathway. (C) 2014 Elsevier Inc. All rights reserved.
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