Article
Biochemistry & Molecular Biology
Jie Liu, Chuan Xia, Huixue Dong, Pan Liu, Ruizhen Yang, Lichao Zhang, Xu Liu, Jizeng Jia, Xiuying Kong, Jiaqiang Sun
Summary: This study reveals the molecular basis of Ms2-induced male sterility in wheat, showing that Ms2 interacts with TaRomo1 and regulates the biosynthesis of ROS signals, thus affecting wheat anther development.
Article
Biochemistry & Molecular Biology
Koujun Zhu, Jun Zhu, Jichun Geng, Yongjian Zhang, Yan Qin, Fudong Wang, Yuan Weng
Summary: This study investigated the role of circSNX6 in drug resistance of NSCLC exposed to cisplatin, revealing its influence on cell viability, proliferation, and apoptosis by regulating miR-137 and CXCL12. These findings provide solid groundings for further understanding of NSCLC pathogenesis and therapeutic development.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biotechnology & Applied Microbiology
Yuanliang Yan, Xiaoxin Yang, Ning Han, Yuanhong Liu, Qiuju Liang, Liu-Gen Li, Jun Hu, Tong-Fei Li, Zhijie Xu
Summary: Dihydroartemisinin (DHA), derived from Artemisia annua, has potential as an anti-cancer agent, but its clinical use is limited due to poor water solubility and bioavailability. In this study, a metal-organic framework (MOF) called ZIF-DHA was developed to enhance the therapeutic activity of DHA against ovarian cancer. The ZIF-DHA nanoparticles showed improved anti-tumor effects, reducing reactive oxygen species (ROS) production and inducing apoptotic cell death. The overexpression of reactive oxygen species modulator 1 (ROMO1) reversed the effects of ZIF-DHA, suggesting it as a potential therapeutic target.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Pathology
Eva Tsoneva, Polina Damyanova Dimitrova, Metodi Metodiev, Velizar Shivarov, Mariela Vasileva-Slaveva, Angel Yordanov
Summary: This study examined the expression of ROMO1 in cervical cancer patients and found that its levels were significantly higher in early stage tumors compared to advanced tumors, suggesting the possible role of ROS in the progression of cervical cancer.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Kwan Ho Tang, Shuai Li, Alireza Khodadadi-Jamayran, Jayu Jen, Han Han, Kayla Guidry, Ting Chen, Yuan Hao, Carmine Fedele, John A. Zebala, Dean Y. Maeda, James G. Christensen, Peter Olson, Argus Athanas, Cynthia A. Loomis, Aristotelis Tsirigos, Kwok-Kin Wong, Benjamin G. Neel
Summary: Our study suggests that inhibiting the SHP2/RAS/ERK pathway leads to upregulation of CXCR2 ligands and recruitment of S100A8 hi gMDSCs, suppressing T cells in non-small cell lung cancer. Combining SHP2/CXCR2 inhibitors can block gMDSC immigration, enhance Th1 polarization, induce highly cytotoxic CD8 + KLRG1 + effector T cells, and improve survival.
Article
Biochemistry & Molecular Biology
Nang Lae Lae Phoo, Amonnat Sukhamwang, Pornngarm Dejkriengkraikul, Supachai Yodkeeree
Summary: Diclofenac (DCF) enhances cisplatin resistance in signet ring cell gastric carcinoma cells by promoting cell death through intracellular reactive oxygen species (ROS) and inhibiting cell survival signal transduction pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Zihan Cui, Dapeng Li, Jun Zhao, Kai Chen
Summary: This study demonstrates that the combination of Falnidamol (FLD) and cisplatin (DDP) effectively inhibits the progression of non-small-cell lung cancer (NSCLC). FLD enhances the cytotoxicity of DDP and reduces the proliferation of NSCLC cells. The combination treatment induces cell cycle arrest, DNA damage, and apoptosis through the generation of reactive oxygen species (ROS). Furthermore, it triggers ferroptosis and inhibits epithelial to mesenchymal transition (EMT) and epidermal growth factor receptor (EGFR) phosphorylation in NSCLC cells. Animal studies confirm the therapeutic efficacy of FLD/DDP in reducing tumor growth and lung metastasis.
FREE RADICAL BIOLOGY AND MEDICINE
(2022)
Article
Oncology
Nasser K. Altorki, Timothy E. McGraw, Alain C. Borczuk, Ashish Saxena, Jeffrey L. Port, Brendon M. Stiles, Benjamin E. Lee, Nicholas J. Sanfilippo, Ronald J. Scheff, Bradley B. Pua, James F. Gruden, Paul J. Christos, Cathy Spinelli, Joyce Gakuria, Manik Uppal, Bhavneet Binder, Olivier Elemento, Karla Ballman, Silvia C. Formenti
Summary: The combination of neoadjuvant durvalumab and stereotactic body radiotherapy in early-stage NSCLC patients shows a high major pathological response rate and is well tolerated, suggesting its potential in treatment, although it comes with certain adverse events.
Article
Medicine, Research & Experimental
Alaguvel Valliammai, Anthonymuthu Selvaraj, Pandiyan Muthuramalingam, Arumugam Priya, Manikandan Ramesh, Shunmugiah Karutha Pandian
Summary: This study evaluated the inhibitory potential of thymol against MRSA by targeting its production of staphyloxanthin, resulting in increased sensitivity to oxidative stress and neutrophil killing. Thymol was found to interact with CrtM and inhibit staphyloxanthin, making MRSA cells more susceptible to antibiotic treatment. These findings suggest the therapeutic potential of thymol in combating MRSA infections.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Jacqulyne P. Robichaux, Xiuning Le, R. S. K. Vijayan, J. Kevin Hicks, Simon Heeke, Yasir Y. Elamin, Heather Y. Lin, Hibiki Udagawa, Ferdinandos Skoulidis, Hai Tran, Susan Varghese, Junqin He, Fahao Zhang, Monique B. Nilsson, Lemei Hu, Alissa Poteete, Waree Rinsurongkawong, Xiaoshan Zhang, Chenghui Ren, Xiaoke Liu, Lingzhi Hong, Jianjun Zhang, Lixia Diao, Russell Madison, Alexa B. Schrock, Jennifer Saam, Victoria Raymond, Bingliang Fang, Jing Wang, Min Jin Ha, Jason B. Cross, Jhanelle E. Gray, John Heymach
Summary: The study characterized the mutational landscape in 16,715 patients with EGFR-mutant NSCLC and established the structure-function relationship of EGFR mutations on drug sensitivity. EGFR mutations can be separated into four distinct subgroups based on sensitivity and structural changes, predicting patient outcomes following treatment with EGFR inhibitors better than traditional exon-based groups. This structure-based approach delineates functional groups of EGFR mutations that can effectively guide treatment choices and suggest potential improvement in prediction of drug sensitivity to targeted therapies in oncogenes with diverse mutations.
Article
Biochemistry & Molecular Biology
Deok-Gyun You, Hye-Ra Lee, Hong-Kyu Kim, Gi-Young Lee, Young-Do Yoo
Summary: The emergence of multidrug-resistant bacteria due to antibiotic abuse is a global health problem. AmpR-22, derived from the Romo1 protein, has been optimized for enhanced antimicrobial activity against a broad spectrum of bacteria, including MDR strains, showing significant survival rates in mice models of sepsis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Plant Sciences
Ruirui Jiang, Shichen Zhou, Xiaowen Da, Tao Chen, Jiming Xu, Peng Yan, Xiaorong Mo
Summary: In this study, a lesion mimic mutant (LMM) in rice, rust spots rice (rsr1), was identified and the mutated gene OsUBP2 was characterized. The mutation in OsUBP2 led to ROS accumulation, chloroplast structural defects, and programmed cell death, while weakening rice resistance to pathogens.
Article
Biochemistry & Molecular Biology
Honghui Wang, Jingjing Dong, Gaozhi Li, Yingjun Tan, Hai Zhao, Lijun Zhang, Yixuan Wang, Zebing Hu, Xinsheng Cao, Fei Shi, Shu Zhang
Summary: Experimental findings have shown that simulated microgravity or radiation can decrease MafG expression and increase apoptosis in MC3T3-E1 cells; meanwhile, increased ROS levels facilitate apoptosis in cells.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Lianxiang Luo, Guangxiang Xu
Summary: In this study, fascaplysin was found to inhibit migration and reverse the epithelial-mesenchymal transition phenotype by regulating the wnt/beta-catenin signaling pathway. Further research showed that fascaplysin induced ferroptosis and apoptosis in non-small cell lung cancer cells. Additionally, fascaplysin enhanced the efficacy of anti-PD-1 immunotherapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Fisheries
W. M. Gayashani Sandamalika, H. M. V. Udayantha, D. S. Liyanage, Chaehyeon Lim, Gaeun Kim, Hyukjae Kwon, Jehee Lee
Summary: In this study, the Romo1 homolog from the black rockfish was identified and characterized. The results showed that SsRomo1 plays an important role in immune response and tissue homeostasis.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)