Article
Environmental Sciences
Jian Wang, Qing Yang, Jinling Han, Zidian He, Min Yang, Xiuping Wang, Xiaohu Lin
Summary: The study found that sweet maize showed differential responses to nicosulfuron stress in terms of sugar metabolism enzymes, starch metabolism enzymes, non-enzyme substances, and expression of key enzyme genes. Under nicosulfuron stress, compared with the nicosulfuron-tolerant line HK301, the nicosulfuron-sensitive line HK320 had significantly reduced stem and root dry matter accumulation, resulting in a lower root-to-shoot ratio. Additionally, the nicosulfuron stress significantly increased the sucrose, soluble sugar, and starch contents in leaves and roots of the nicosulfuron-tolerant line HK301, which may be related to enhanced carbohydrate metabolism and upregulation of sucrose transporter genes.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Review
Biochemistry & Molecular Biology
Jinmi Yoon, Lae-Hyeon Cho, Win Tun, Jong-Seong Jeon, Gynheung An
Summary: Sucrose plays a crucial role in controlling various developmental and metabolic processes in plants, serving as a preferred signaling molecule that affects carbohydrate metabolism, protein accumulation, and anthocyanin accumulation. Sucrose also influences gene expression and activity of key enzymes in sugar metabolism pathways, thereby regulating growth and development in plants.
Article
Multidisciplinary Sciences
Qin-Xin Bao, Xin-Rong Mu, Chen Tong, Cong Li, Wen-Zhe Tao, Sheng-Ting Zhao, Yu-xin Liu, Wan-Ni Wang, Yu-ting Wei, Fu-Huan Yu, Jing-wen Wang, Zhi-Lan Sun, Bing-Ling Fan, Jia Sun, Chen Wang, Gary J. Loake, Lai-Sheng Meng, David Baulcombe
Summary: Stomata are pores that regulate plant gas exchange and water/nutrient uptake. This study investigates how carbohydrate status in preexisting leaves affects stomatal formation in newly developing leaves. The researchers found that the Glc status of preexisting leaves determines systemic stomatal development within newly developing leaves through the HXK1-EIN3-SUC2 module.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Plant Sciences
Anna Wawrzynska, Justyna Piotrowska, Anastasia Apodiakou, Franziska Bruckner, Rainer Hoefgen, Agnieszka Sirko
Summary: The homeostasis of major macronutrient metabolism, particularly sulfur metabolism and glucose signaling, play important roles in plant growth and stress responses. This study demonstrates that the transcription factor SLIM1 is involved in glucose signaling during sulfur deficiency in Arabidopsis, affecting germination rate and gene expression. SLIM1 modulates sulfur metabolism and directly controls PAP1 expression, leading to changes in anthocyanin production under sulfur deficiency stress.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Review
Plant Sciences
Daniel Wipf, Carole Pfister, Arnaud Mounier, Nathalie Leborgne-Castel, Wolf B. Frommer, Pierre-Emmanuel Courty
Summary: Hexoses and disaccharides are essential carbon sources for physiological processes, with sugar transport mediated by transport proteins across different organs and playing key roles in interactions with microbes. Studying sugar transporter interactions can uncover important players in biologically and physiologically relevant processes.
TRENDS IN PLANT SCIENCE
(2021)
Article
Plant Sciences
Lily Chen, Diep R. Ganguly, Sarah H. Shafik, Florence Danila, Christopher P. L. Grof, Robert E. Sharwood, Robert T. Furbank
Summary: The localization of SWEET4 protein in the seed and stem of Setaria viridis suggests its involvement in supplying sugars to carbon sink tissues. SWEET proteins play a crucial role in apoplastic sugar transport during phloem unloading and the post-phloem pathway in developing seeds. The study provides evidence for the role of SWEET proteins in the apoplastic transport pathway and proposes a pathway for post-phloem sugar transport into the seed.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Plant Sciences
Shuhui Zhang, Hui Wang, Tong Wang, Jing Zhang, Wenjun Liu, Hongcheng Fang, Zongying Zhang, Futian Peng, Xuesen Chen, Nan Wang
Summary: This study investigated sugar accumulation and the underlying mechanisms in the progenies of a hybridization between high-sugar apples and high-flavonoid apple germplasm. The results showed that MdSWEET9b promotes sugar accumulation by transporting sucrose, and MdWRKY9 and MdbZIP23/46 regulate its expression in the ABA signaling pathway, thereby influencing sugar accumulation.
Article
Plant Sciences
Si Shen, Si Ma, Xian-Min Chen, Fei Yi, Bin-Bin Li, Xiao-Gui Liang, Sheng-Jin Liao, Li-Hong Gao, Shun-Li Zhou, Yong-Ling Ruan
Summary: This study reveals the transcriptional landscape of sugar transport and utilization in maize grains through data mining, histological, and functional analysis. The findings suggest that drought represses the expression of genes involved in exporting sucrose, but enhances the expression of genes for uptake of extracellular sugars.
Review
Plant Sciences
Qiyu Xu, Johannes Liesche
Summary: This study broadens the understanding of proteins potentially influencing leaf sugar export rate in Arabidopsis thaliana, providing insights into the regulation of these proteins. By integrating information on potential target proteins, the analysis identifies potential control points and co-regulated genes, including sucrose transporters and proton pumps. This analysis can guide future research on the regulatory network controlling leaf sugar export and help identify regulatory factors linking sugar export rate to major signaling pathways.
JOURNAL OF EXPERIMENTAL BOTANY
(2021)
Article
Forestry
Wiebke Miehe, Laura Czempik, Franz Klebl, Gertrud Lohaus
Summary: Phloem loading mechanisms in herbaceous plants are well studied, but less is known for trees. This study examined tissue-specific sugar and starch contents, as well as sugar concentration in mesophyll cells of different-sized trees, and found that phloem loading in tall trees involves active steps and may involve sucrose uptake transporters (SUTs).
Article
Plant Sciences
Peixian Nie, Laiping Wang, Miao Li, Deguo Lyu, Sijun Qin, Xiaomin Xue
Summary: In this study, MdSWEET23 was identified as an important sugar transporter in apple fruits, with overexpression leading to increased soluble sugar content and silencing resulting in reduced sucrose and sorbitol content. Ectopic overexpression of MdSWEET23 in tomato altered sugar metabolism and distribution, enhancing cold stress tolerance.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Plant Sciences
Tengfei Liu, Md Abu Kawochar, Shahnewaz Begum, Enshuang Wang, Tingting Zhou, Shenglin Jing, Tiantian Liu, Liu Yu, Bihua Nie, Botao Song
Summary: Cold-induced sweetening is a severe issue in the potato processing industry. This study identifies StTST1 as the sugar transporter with the highest expression in potato tubers during postharvest cold storage. Knockdown of StTST1 reduces sugar accumulation and improves the frying quality of cold-stored tubers. Suppression of StTST1 promotes starch synthesis and inhibits starch degradation, possibly through the down-regulation of beta-amylase StBAM1. These findings provide a new strategy to improve the quality of cold-stored potatoes and reduce acrylamide content in potato chips.
HORTICULTURE RESEARCH
(2023)
Article
Plant Sciences
Md Dulal Ali Mollah, Xian Zhang, Li Zhao, Xiaohan Jiang, Collins O. Ogutu, Qian Peng, Mohammad A. A. Belal, Qiurui Yang, Yaming Cai, Elsayed Nishawy, Sylvia Cherono, Lu Wang, Yuepeng Han
Summary: This study identified two vacuolar invertase inhibitor genes, PpINHa and PpINH3, involved in sugar accumulation in peach fruits. Overexpression of PpINH3 increased sugar content, while overexpression of PpINHa had the opposite effect. Surprisingly, both PpINH3 and PpINHa had no physical interaction with vacuolar invertase (VIN), and the expression of PpVIN genes in ripe fruits was negligible. The results suggest that the regulatory role of PpINHa and PpINH3 in sugar accumulation is likely due to their impact on genes related to fruit sugar metabolism and transport.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Heting Fang, Yanna Shi, Shengchao Liu, Rong Jin, Jun Sun, Donald Grierson, Shaojia Li, Kunsong Chen
Summary: The transcription factor CitZAT5 plays a role in sugar metabolism and transport in citrus fruit by regulating the genes CitSUS5 and CitSWEET6. This promotes sugar accumulation and increases the proportion of hexose. Sugars are important for plant development, and their accumulation and proportion play crucial roles in the quality and attractiveness of fruits. The difference in sweetness between two varieties of citrus fruit, Gongchuan and Youliang, is related to the expression levels of CitSUS5 and CitSWEET6, with Youliang having higher expression levels.
Article
Plant Sciences
Sylvie Dinant, Rozenn Le Hir
Summary: Plant growth and development depend on the transport and utilization of sugars produced during photosynthesis. Although many factors involved in sugar homeostasis and signaling have been identified, our understanding of the coordination of sugar transport and signaling in both intracellular and intercellular processes is limited. More research is needed to explore the interplay between sugar transport/signaling and vascular system development.
PHYSIOLOGIA PLANTARUM
(2022)
Article
Biochemistry & Molecular Biology
Myoung-Goo Choi, Eui Joong Kim, Ji-Young Song, Sang-Bong Choi, Seong-Woo Cho, Chul Soo Park, Chon-Sik Kang, Youn-Il Park
PLANT MOLECULAR BIOLOGY
(2020)
Article
Multidisciplinary Sciences
Hee Wook Yang, Ji Young Song, Sung Mi Cho, Hak Cheol Kwon, Cheol-Ho Pan, Youn-Il Park
SCIENTIFIC REPORTS
(2020)
Article
Biotechnology & Applied Microbiology
Jayaraman Vikramathithan, Kwon Hwangbo, Jong-Min Lim, Ka-Min Lim, Da Yeon Kang, Youn-Il Park, Won-Joong Jeong
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2020)
Article
Microbiology
Md Nurul Islam, Md Sarafat Ali, Seong-Jin Choi, Youn-Il Park, Kwang-Hyun Baek
Review
Plant Sciences
Ki-Beom Moon, Ji-Sun Park, Youn-Il Park, In-Ja Song, Hyo-Jun Lee, Hye Sun Cho, Jae-Heung Jeon, Hyun-Soon Kim
Article
Biochemistry & Molecular Biology
Ji-Young Song, Ha Yong Lee, Hee Wook Yang, Ji-Joon Song, J. Clark Lagarias, Youn-Il Park
JOURNAL OF BIOLOGICAL CHEMISTRY
(2020)
Article
Microbiology
Seok Won Jeong, Kwon HwangBo, Jong Min Lim, Seung Won Nam, Bong Soo Lee, Byeong-ryool Jeong, Yong Keun Chang, Won-Joong Jeong, Youn-Il Park
Article
Biotechnology & Applied Microbiology
Myoung-Goo Choi, Eui Joong Kim, Jin Jeon, Seok Won Jeong, Kyeong-Hoon Kim, Kyeong-Min Kim, Chul Soo Park, Chon-Sik Kang, Youn-Il Park
PLANT BIOTECHNOLOGY REPORTS
(2020)
Article
Plant Sciences
Yanhai Gong, Nam K. Kang, Young U. Kim, Zengbin Wang, Li Wei, Yi Xin, Chen Shen, Qintao Wang, Wuxin You, Jong-Min Lim, Suk-Won Jeong, Youn-Il Park, Hee-Mock Oh, Kehou Pan, Eric Poliner, Guanpin Yang, Yonghua Li-Beisson, Yantao Li, Qiang Hu, Ansgar Poetsch, Eva M. Farre, Yong K. Chang, Won-Joong Jeong, Byeong-ryool Jeong, Jian Xu
Article
Plant Sciences
Ki-Beom Moon, Ji-Sun Park, Su-Jin Park, Hyo-Jun Lee, Hye-Sun Cho, Sung-Ran Min, Youn-Il Park, Jae-Heung Jeon, Hyun-Soon Kim
Summary: Efficient extraction of protoplasts and stable regeneration protocols are prerequisites for the continuous expansion and development of protoplast utilization systems. This study establishes an efficient process from protoplast isolation to in vitro shoot regeneration, achieving a significant increase in protoplast yield and successful shoot development.
Article
Agricultural Engineering
Ae Jin Ryu, Byeong-ryool Jeong, Nam Kyu Kang, Seungjib Jeon, Min Gi Sohn, Hyo Jin Yun, Jong Min Lim, Seok Won Jeong, Youn-Il Park, Won Joong Jeong, Sunghoon Park, Yong Keun Chang, Ki Jun Jeong
Summary: Establishing a safe harboring transgene expression system in Nanno-chloropsis microalgae enabled significantly higher expression of the FAD12 gene and increased production of linoleic acid (LA) and eicosapentaenoic acid (EPA). This approach provides excellent proof of concept for successful genetic/metabolic engineering in microalgae and other organisms.
BIORESOURCE TECHNOLOGY
(2021)
Article
Plant Sciences
Rupak Timilsina, Yongmin Kim, Sanghoon Park, Hyunsoo Park, Sung-Jin Park, Jin Hee Kim, Ji-Hwan Park, Doa Kim, Youn-Il Park, Daehee Hwang, Jong-Chan Lee, Hye Ryun Woo
Summary: The transcription factor ORE15 in Arabidopsis is involved in regulating the size of the root apical meristem. ORE15 mediates the antagonistic interaction between auxin and cytokinin signaling, controlling the coordination of cell division and differentiation, thereby affecting the size of the root apical meristem.
JOURNAL OF EXPERIMENTAL BOTANY
(2022)
Article
Plant Sciences
Ki-Beom Moon, Su-Jin Park, Ji-Sun Park, Hyo-Jun Lee, Seung Young Shin, Soo Min Lee, Gyung Ja Choi, Sang-Gyu Kim, Hye Sun Cho, Jae-Heung Jeon, Yong-Sam Kim, Youn-Il Park, Hyun-Soon Kim
Summary: This study established an efficient CRISPR/Cas9 genome editing protocol for potato, targeting the susceptibility gene SR4 to develop Phytophthora infestans resistant mutants. The co-expression of StEDS1 and StPAD4 induced the accumulation of salicylic acid (SA) in the mutants, enhancing their resistance to the pathogen. However, high SA content inhibited the growth of mutants and induced a dwarf phenotype.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Plant Sciences
Jong-Min Lim, Sokyong Jung, Jae-Sun In, Youn-Il Park, Won-Joong Jeong
Summary: Temperature is crucial for regulating growth in algae. Temperature stress can lead to oxidative damage in algae, but enhancing oxidative stress resistance through alcohol metabolism could improve tolerance.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Chanhee Kim, Sun Ji Kim, Jinkil Jeong, Eunae Park, Eunkyoo Oh, Youn-Il Park, Pyung Ok Lim, Giltsu Choi
MOLECULES AND CELLS
(2020)
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
